- 同
- CBG
- 同
- CBG
WordNet
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- a family of proteins found in blood and milk and muscle and in plant seed
PrepTutorEJDIC
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- グロブリン(動植物組織内の純蛋白(たんぱく)質の総称)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/21 21:47:31」(JST)
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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 |
Crystal structure of corticosteroid-binding globulin. The reactive loop has been cleaved at the region highlighted in blue.[1]
|
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
2VDX, 2VDY, 4BB2, 4C41, 4C49
|
|
|
Identifiers |
Symbols |
SERPINA6 ; CBG |
External IDs |
OMIM: 122500 MGI: 88278 HomoloGene: 20417 ChEMBL: 2421 GeneCards: SERPINA6 Gene |
Gene ontology |
Molecular function |
• serine-type endopeptidase inhibitor activity
• steroid binding
|
Cellular component |
• extracellular space
• extracellular exosome
|
Biological process |
• transport
• glucocorticoid metabolic process
• negative regulation of endopeptidase activity
|
Sources: Amigo / QuickGO |
|
RNA expression pattern |
|
More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
866 |
12401 |
Ensembl |
ENSG00000170099 |
ENSMUSG00000060807 |
UniProt |
P08185 |
Q06770 |
RefSeq (mRNA) |
NM_001756 |
NM_007618 |
RefSeq (protein) |
NP_001747 |
NP_031644 |
Location (UCSC) |
Chr 14:
94.3 – 94.32 Mb |
Chr 12:
103.65 – 103.66 Mb |
PubMed search |
[1] |
[2] |
|
Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is an alpha-globulin.[2][3][4]
Contents
- 1 Function
- 2 Binding
- 3 Synthesis
- 4 Clinical significance
- 5 See also
- 6 References
- 7 Further reading
- 8 External links
Function
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors (serpins) which may have evolved by duplication events.[4]
Binding
Transcortin binds several steroid hormones at high rates:
- Cortisol - Approximately 75% of the cortisol in circulation is bound to transcortin. (The rest is bound to serum albumin.) Cortisol is thought to be biologically active only when it is not bound to transcortin.
- Cortisone[5]
- Deoxycorticosterone (DOC)[5]
- Corticosterone - About 78% of serum corticosterone is bound to transcortin.
- Aldosterone - Approximately 17% of serum aldosterone is bound to transcortin, while another 47% is bound to serum albumin. The remaining 36% is free.[6]
- Progesterone - Approximately 18% of serum progesterone is bound to transcortin, while another 80% of it is bound to serum albumin. The remaining 2% is free.[7]
- 17-Hydroxyprogesterone[5]
In addition, approximately 4% of serum testosterone is bound to transcortin.[8] A similarly small fraction of serum estradiol is bound to transcortin as well.[citation needed]
Synthesis
Transcortin is produced by the liver and is increased by estrogens.[9]
Clinical significance
Mutations in this gene are rare. Only four mutations have been described, often in association with fatigue and chronic pain. [10] This mechanism for these symptoms is not known. This condition must be distinguished from secondary hypocortisolism. Exogenous hydrocortisone does not appear to improve the fatigue.
Hepatic synthesis of corticosteroid-binding globulin more than doubles in pregnancy; that is, unbound plasma cortisol in term pregnancy is approximately 2.5 times that of nonpregnant women.[11]
See also
- Serpin
- Circaseptan, 7-day biological cycle
References
- ^ PDB: 2VDX ; Zhou A, Wei Z, Stanley PL, Read RJ, Stein PE, Carrell RW (June 2008). "The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release". J. Mol. Biol. 380 (1): 244–51. doi:10.1016/j.jmb.2008.05.012. PMID 18513745.
- ^ Hammond GL, Smith CL, Goping IS, Underhill DA, Harley MJ, Reventos J, Musto NA, Gunsalus GL, Bardin CW (Aug 1987). "Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors". Proc Natl Acad Sci U S A 84 (15): 5153–7. doi:10.1073/pnas.84.15.5153. PMC 298812. PMID 3299377.
- ^ Byth BC, Billingsley GD, Cox DW (Jul 1994). "Physical and genetic mapping of the serpin gene cluster at 14q32.1: allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency". Am J Hum Genet 55 (1): 126–33. PMC 1918218. PMID 7912884.
- ^ a b "Entrez Gene: SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6".
- ^ a b c E. Edward Bittar; Neville Bittar (1997). Molecular and Cellular Endocrinology. Elsevier. p. 238. ISBN 978-1-55938-815-3. Retrieved 23 August 2012.
- ^ Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. 24 April 2001. p. 712. ISBN 978-0-7817-1750-2. Retrieved 23 August 2012.
- ^ Negi (2009). Introduction To Endocrinology. PHI Learning Pvt. Ltd. p. 268. ISBN 978-81-203-3850-0. Retrieved 23 August 2012.
- ^ Dunn JF, Nisula BC, Rodbard D (July 1981). "Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma". The Journal of Clinical Endocrinology and Metabolism 53 (1): 58–68. doi:10.1210/jcem-53-1-58. PMID 7195404.
- ^ Musa BU, Seal US, Doe RP (September 1965). "Elevation of certain plasma proteins in man following estrogen administration: a dose-response relationship". J. Clin. Endocrinol. Metab. 25 (9): 1163–6. doi:10.1210/jcem-25-9-1163. PMID 4284083.
- ^ Torpy DJ, Lundgren BA, Ho JT, Lewis JG, Scott HS, Mericq V (January 2012). "CBG Santiago: a novel CBG mutation". J. Clin. Endocrinol. Metab. 97 (1): E151–5. doi:10.1210/jc.2011-2022. PMID 22013108.
- ^ Rosen MI, Shnider SM, Levinson G, Hughes (2002). Shnider and Levinson's anesthesia for obstetrics. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 13. ISBN 0-683-30665-0.
Further reading
- Rosner W, Beers PC, Awan T, Khan MS (1976). "Identification of corticosteroid-binding globulin in human milk: measurement with a filter disk assay.". J. Clin. Endocrinol. Metab. 42 (6): 1064–73. doi:10.1210/jcem-42-6-1064. PMID 932172.
- Smith CL, Power SG, Hammond GL (1992). "A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol.". J. Steroid Biochem. Mol. Biol. 42 (7): 671–6. doi:10.1016/0960-0760(92)90107-T. PMID 1504007.
- Brotherton J (1990). "Cortisol and transcortin in human seminal plasma and amniotic fluid as estimated by modern specific assays.". Andrologia 22 (3): 197–204. doi:10.1111/j.1439-0272.1990.tb01966.x. PMID 2240617.
- Seralini GE, Bérubé D, Gagné R, Hammond GL (1991). "The human corticosteroid binding globulin gene is located on chromosome 14q31-q32.1 near two other serine protease inhibitor genes.". Hum. Genet. 86 (1): 73–5. doi:10.1007/bf00205177. PMID 2253941.
- Underhill DA, Hammond GL (1990). "Organization of the human corticosteroid binding globulin gene and analysis of its 5'-flanking region.". Mol. Endocrinol. 3 (9): 1448–54. doi:10.1210/mend-3-9-1448. PMID 2608068.
- Loric S, Egloff M, Domingo M et al. (1990). "Immunochemical characterization of corticosteroid-binding globulin in human bronchoalveolar fluid.". Clin. Chim. Acta 186 (1): 19–23. doi:10.1016/0009-8981(89)90198-8. PMID 2612005.
- Heubner A, Belovsky O, Müller W et al. (1987). "Application of liquid-liquid partition chromatography in the simultaneous purification of sex-hormone-binding globulin and corticosteroid-binding globulin.". J. Chromatogr. 397: 419–34. doi:10.1016/S0021-9673(01)85027-5. PMID 2821037.
- Kato EA, Hsu BR, Kuhn RW (1988). "Comparative structural analyses of corticosteroid binding globulin.". J. Steroid Biochem. 29 (2): 213–20. doi:10.1016/0022-4731(88)90268-3. PMID 3347061.
- Bardin CW, Gunsalus GL, Musto NA et al. (1988). "Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors.". J. Steroid Biochem. 30 (1-6): 131–9. doi:10.1016/0022-4731(88)90085-4. PMID 3386241.
- Hammond GL, Langley MS (1986). "Identification and measurement of sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) in human saliva.". Acta Endocrinol. 112 (4): 603–8. doi:10.1530/acta.0.1120603. PMID 3751467.
- Agrimonti F, Frairia R, Fornaro D et al. (1983). "Circadian and circaseptan rhythmicities in corticosteroid-binding globulin (CBG) binding activity of human milk.". Chronobiologia 9 (3): 281–90. PMID 7172869.
- Misao R, Hori M, Ichigo S et al. (1995). "Levels of sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) messenger ribonucleic acid (mRNAs) in ovarian endometriosis.". Reprod. Nutr. Dev. 35 (2): 155–65. doi:10.1051/rnd:19950204. PMID 7734053.
- Misao R, Hori M, Ichigo S et al. (1995). "Corticosteroid-binding globulin mRNA levels in human uterine endometrium.". Steroids 59 (10): 603–7. doi:10.1016/0039-128X(94)90055-8. PMID 7878688.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Avvakumov GV, Hammond GL (1994). "Glycosylation of human corticosteroid-binding globulin. Differential processing and significance of carbohydrate chains at individual sites.". Biochemistry 33 (19): 5759–65. doi:10.1021/bi00185a012. PMID 8180202.
- Van Baelen H, Power SG, Hammond GL (1993). "Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93.". Steroids 58 (6): 275–7. doi:10.1016/0039-128X(93)90072-U. PMID 8212073.
- Misao R, Nakanishi Y, Fujimoto J et al. (1996). "Expression of corticosteroid-binding globulin mRNA in human uterine endometrial cancers.". Steroids 60 (10): 720–4. doi:10.1016/0039-128X(95)00106-Z. PMID 8539782.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
External links
- Transcortin at the US National Library of Medicine Medical Subject Headings (MeSH)
- The MEROPS online database for peptidases and their inhibitors: I04.954
- SERPINA6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
Proteins: carrier proteins
|
|
Fatty acid |
- FABP1
- FABP2
- FABP3
- FABP4
- FABP5
- FABP6
- FABP7
|
|
Hormone |
- peptide hormone: Follistatin
- Growth hormone binding protein
- Insulin-like growth factor binding protein
- IGFBP1
- IGFBP2
- IGFBP3
- IGFBP4
- IGFBP5
- IGFBP6
- IGFBP7
- Neurophysins
- steroid hormone: Sex hormone binding globulin/Androgen binding protein
- Transcortin
- Thyroxine-binding globulin
- Transthyretin
|
|
Metal/element |
- calcium
- Calcium-binding protein
- Calmodulin-binding proteins
- copper
- iron
- Iron-binding proteins
- Transferrin receptor
|
|
Vitamin |
- Retinol binding protein
- Transcobalamin
|
|
Pigment |
- Plant Light-Harvesting Complex
- Orange Carotenoid Protein
- Phycobiliprotein
- Photosynthetic Reaction Centers
- Phytochrome
- Rhodopsin
|
|
Other |
- Acyl carrier protein
- Adaptor protein
- Cholesterylester transfer protein
- F-box protein
- GTP-binding protein
- Latent TGF-beta binding protein
- Major urinary proteins
- Membrane transport protein
- Odorant binding protein
|
|
Index of proteins
|
|
Description |
- Proteins
- Membrane
- Globular
- Antibodies
- Fibrous
|
|
|
Proteins: Globular proteins
|
|
Serum globulins |
Alpha globulins
|
serpins:
|
- alpha-1 (Alpha 1-antichymotrypsin, Alpha 1-antitrypsin)
- alpha-2 (Alpha 2-antiplasmin)
- Antithrombin (Heparin cofactor II)
|
|
carrier proteins:
|
- alpha-1 (Transcortin)
- alpha-2 (Ceruloplasmin)
- Retinol binding protein
|
|
other:
|
- alpha-1 (Orosomucoid)
- alpha-2 (alpha-2-Macroglobulin, Haptoglobin)
|
|
|
Beta globulins
|
carrier proteins:
|
- Sex hormone-binding globulin
- Transferrin
|
|
other:
|
- Angiostatin
- Hemopexin
- Beta-2 microglobulin
- Factor H
- Plasminogen
- Properdin
|
|
|
Gamma globulin
|
|
|
Other
|
- Fibronectin (fFN: Fetal fibronectin)
- Macroglobulin/Microglobulin
- Transcobalamin
|
|
|
Other globulins |
- Beta-lactoglobulin
- Thyroglobulin
- Alpha-lactalbumin
|
|
Albumins |
Egg white
|
- Conalbumin
- Ovalbumin
- Avidin
|
|
Serum albumin
|
- Human serum albumin
- Bovine serum albumin
- Prealbumin
|
|
Other
|
- C-reactive protein
- Lactalbumin (Alpha-lactalbumin)
- Parvalbumin
- Ricin
|
|
|
- see also disorders of globin and globulin proteins
Index of proteins
|
|
Description |
- Proteins
- Membrane
- Globular
- Antibodies
- Fibrous
|
|
|
Serpins
|
|
inhibitory |
- Alpha 1-antichymotrypsin
- Alpha 1-antitrypsin
- Alpha 2-antiplasmin
- Antithrombin
- C1-inhibitor
- Heparin cofactor II
- Protein C inhibitor
- Plasminogen activator inhibitor-1
- Plasminogen activator inhibitor-2
- Protein Z-related protease inhibitor
- SERPINA1
- SERPINA2
- SERPINA3
- SERPINA4
- SERPINA5
- SERPINA6
- SERPINA7
- SERPINA8
- SERPINA9
- SERPINA14
- SERPINB1
- SERPINB2
- SERPINB3
- SERPINB4
- SERPINB5
- SERPINB6
- SERPINB7
- SERPINB8
- SERPINB9
- SERPINB13
- SERPINC1
- SERPIND1
- SERPINE1
- SERPINE2
- SERPINE2
- SERPINF1
- SERPING1
- SERPINH1
- SERPINI1
- SERPINI2
|
|
Cross class inhibitory |
|
|
noninhibitory |
- Heat shock protein 47
- Maspin
- Ovalbumin
- SERPINF1
- Thyroxine-binding globulin
- Transcortin
- SERPINF1
|
|
see also disorders of globin and globulin proteins
|
|
Protein, glycoconjugate: glycoproteins and glycopeptides
|
|
Mucoproteins |
Mucin
|
- CD43
- CD164
- MUC1
- MUC2
- MUC3A
- MUC3B
- MUC4
- MUC5AC
- MUC5B
- MUC6
- MUC7
- MUC8
- MUC12
- MUC13
- MUC15
- MUC16
- MUC17
- MUC19
- MUC20
|
|
Other
|
- Haptoglobin
- Intrinsic factor
- Orosomucoid
- Peptidoglycan
- Phytohaemagglutinin
- Ovomucin
|
|
|
Proteoglycans |
CS/DS
|
- Decorin
- Biglycan
- Versican
|
|
HS/CS
|
|
|
CS
|
- Chondroitin sulfate proteoglycans: Aggrecan
- Neurocan
- Brevican
- CD44
- CSPG4
- CSPG5
- Platelet factor 4
- Structural maintenance of chromosomes 3
|
|
KS
|
- Fibromodulin
- Lumican
- Keratocan
|
|
HS
|
|
|
|
Other |
- Activin and inhibin
- ADAM
- Alpha 1-antichymotrypsin
- Apolipoprotein H
- CD70
- Asialoglycoprotein
- Avidin
- B-cell activating factor
- 4-1BB ligand
- Cholesterylester transfer protein
- Clusterin
- Colony-stimulating factor
- Hemopexin
- Lactoferrin
- Membrane glycoproteins
- Myelin protein zero
- Osteonectin
- Protein C
- Protein S
- Serum amyloid P component
- Sialoglycoprotein
- CD43
- Glycophorin
- Glycophorin C
- Thrombopoietin
- Thyroglobulin
- Thyroxine-binding proteins
- Transcortin
- Tumor necrosis factor alpha
- Uteroglobin
- Vitronectin
|
|
Index of inborn errors of metabolism
|
|
Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- phospholipid
- cholesterol and steroid
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- nucleotide
|
|
Disorders |
- Citric acid cycle and electron transport chain
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
|
|
Treatment |
|
Index of biochemical families
|
|
Carbohydrates |
- Alcohols
- Glycoproteins
- Glycosides
|
|
Lipids |
- Eicosanoids
- Fatty acids
- Glycerides
- Phospholipids
- Sphingolipids
- Steroids
|
|
Nucleic acids |
|
|
Proteins |
|
|
Other |
|
|
|
UpToDate Contents
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English Journal
- Cortisol responses at baseline and after corticotropin in acute aneurysmal subarachnoid haemorrhage: a prospective study.
- Conway P1, Pretorius CJ2, Ungerer JP2, Lassig-Smith M3, Stuart J3, Jarrett P3, Starr T3, Dunlop R3, Venkatesh B4, Cohen J3.
- Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine.Crit Care Resusc.2015 Mar;17(1):37-42.
- BACKGROUND: Measurements of total plasma cortisol (TPC) in the acute phase of aneurysmal subarachnoid haemorrhage (aSAH) have suggested a high incidence of adrenal insufficiency (AI).OBJECTIVE: To compare TPC and free plasma cortisol (FPC) measurements in acute aSAH and to assess whether rates of di
- PMID 25702760
- Comparison of salivary and calculated free cortisol levels during low and standard dose of ACTH stimulation tests in healthy volunteers.
- Elbuken G1, Tanriverdi F, Karaca Z, Kula M, Gokahmetoglu S, Unluhizarci K, Kelestimur F.
- Endocrine.Endocrine.2015 Mar;48(2):439-43. doi: 10.1007/s12020-014-0378-8. Epub 2014 Aug 13.
- Salivary cortisol (SC) has been increasingly used as a surrogate biomarker of free cortisol (FC) for the assessment of hypothalamo-pituitary-adrenal (HPA) axis, but there are not enough data regarding its use during ACTH stimulation tests. Therefore, we aimed to determine the responses of SC, calcul
- PMID 25115637
- Longitudinal assessment of adrenal function in the early and prolonged phases of critical illness in septic patients: relations to cytokine levels and outcome.
- Vassiliadi DA1, Dimopoulou I, Tzanela M, Douka E, Livaditi O, Orfanos SE, Kotanidou A, Tsagarakis S.
- The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2014 Dec;99(12):4471-80. doi: 10.1210/jc.2014-2619.
- CONTEXT: Adrenal dysfunction remains a controversial issue in critical care. The long-stay intensive care unit (ICU) population may be at increased risk of adrenal insufficiency.OBJECTIVE: We aimed to determine whether adrenal dysfunction develops during the course of sepsis.DESIGN: This is a prospe
- PMID 25148237
Japanese Journal
- 血清CBGと特異的に結合する免疫吸着剤の作成と, それを用いたCBGとcortisolの相互作用の研究:健常者でのCBGとcortisolのKa値の検討
- Comparative study of primates' transcortin: Immunoreactivity and steroid-binding activity.
- Corticosteroid-binding globulin (CBG) の新しい簡易測定法と正常ヒト血清CBG値
Related Links
- cortisol /cor·ti·sol/ (-sol) the major natural glucocorticoid elaborated by the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has mineralocorticoid activity. See hydrocortisone for therapeutic uses. cor·ti·sol (kôr ...
- The free fraction of cortisol in circulation is that which is biologically available to cells. In swine, more than 60% of cortisol is bound to its carrier glycoprotein, porcine corticosteroid-binding globulin (pCBG). The Free Cortisol Index ...
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- 関
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[★]
- 関
- globule、globulus、spherule
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