- 関
- CRF receptor、CRH receptor
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion
PrepTutorEJDIC
- =sense organ / 受信装置
- ホルモン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/08/24 22:09:14」(JST)
[Wiki en表示]
| corticotropin releasing hormone receptor 1 |
| Identifiers |
| Symbol |
CRHR1 |
| Alt. symbols |
CRHR |
| Entrez |
1394 |
| HUGO |
2357 |
| OMIM |
122561 |
| RefSeq |
XM_001128344 |
| UniProt |
P34998 |
| Other data |
| Locus |
Chr. 17 q12-q22 |
| corticotropin releasing hormone receptor 2 |
| Identifiers |
| Symbol |
CRHR2 |
| Entrez |
1395 |
| HUGO |
2358 |
| OMIM |
602034 |
| RefSeq |
NM_001883 |
| UniProt |
Q13324 |
| Other data |
| Locus |
Chr. 7 p21-p15 |
Corticotropin-releasing hormone receptors (CRHRs), also known known as corticotropin-releasing factor receptors (CRFRs) are a G protein-coupled receptor family that binds corticotropin-releasing hormone (CRH).[1] There are two receptors in the family, designated as type I and 2, each encoded by a separate gene (CRHR1 and CRHR2 respectively).
Function
CRHRs are important mediators in the stress response.[2] Cells in the anterior lobe of the pituitary gland known as corticotropes express the receptors and will secrete adrenocorticotropic hormone (ACTH) when stimulated.[3]
References
- ^ Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952.
- ^ Grammatopoulos DK, Chrousos GP (2002). "Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists". Trends Endocrinol. Metab. 13 (10): 436–44. doi:10.1016/S1043-2760(02)00670-7. PMID 12431840.
- ^ Aguilera G, Wynn PC, Harwood JP, Hauger RL, Millan MA, Grewe C, Catt KJ (1986). "Receptor-mediated actions of corticotropin-releasing factor in pituitary gland and nervous system". Neuroendocrinology 43 (1): 79–88. doi:10.1159/000124513. PMID 3012395.
External links
- "Corticotropin-Releasing Factor Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1321.
- Corticotropin-releasing+hormone+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Cell surface receptor: G protein-coupled receptors
|
|
Class A:
Rhodopsin like |
|
|
| Class B: Secretin like |
|
Orphan
|
- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
|
|
|
Other
|
- Brain-specific angiogenesis inhibitor (1
- 2
- 3)
- Cadherin (1
- 2
- 3)
- Calcitonin
- CALCRL
- CD97
- Corticotropin-releasing hormone (1
- 2)
- EMR (1
- 2
- 3)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth hormone releasing hormone
- PACAPR1
- GPR
- Latrophilin (1
- 2
- 3
- ELTD1)
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
|
|
|
Class C: Metabotropic
glutamate / pheromone |
|
Taste
|
- TAS1R (1
- 2
- 3)
- TAS2R (1
- 3
- 4
- 5
- 8
- 9
- 10
- 12
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50)
|
|
|
Other
|
- Calcium-sensing receptor
- GABA B (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
|
|
|
Class F:
Frizzled / Smoothened |
|
Frizzled
|
- Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10)
|
|
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Smoothened
|
|
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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|
|
Neuropeptide receptors
|
|
| G protein-coupled receptor |
|
Hormone receptors
|
|
Hypothalamic
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CRH · FSH · LHRH · TRH · Somatostatin
|
|
|
Pituitary
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Vasopressin (1A, 1B, 2) · Oxytocin · LHCG · TSH
|
|
|
Other
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Atrial natriuretic factor (NPR3) · Calcitonin · Cholecystokinin (A, B) · VIP
|
|
|
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Opioid receptors
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Delta · Kappa · Mu · Nociceptin
|
|
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Other neuropeptide receptors
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Angiotensin · Bradykinin (B1, B2) / Tachykinin (TACR1) · Calcitonin gene-related peptide · Galanin · GPCR neuropeptide (B/W, FF, S, Y) · Neurotensin
|
|
|
| Type I cytokine receptor |
GH · Prolactin
|
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| Enzyme-linked receptor |
Atrial natriuretic factor (NPR1, NPR2)
|
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| Other |
Sigma (1, 2)
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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|
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Neuropeptidergics
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| Cholecystokinin |
|
CCKA
|
- Agonists: Cholecystokinin
- CCK-4
Antagonists: Asperlicin
- Proglumide
- Lorglumide
- Devazepide
- Dexloxiglumide
|
|
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CCKB
|
- Agonists: Cholecystokinin
- CCK-4
- Gastrin
Antagonists: Proglumide
- CI-988
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| CRH |
|
CRF1
|
- Agonists: Corticotropin releasing hormone
Antagonists: Antalarmin
- CP-154,526
- Pexacerfont
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|
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CRF2
|
- Agonists: Corticotropin releasing hormone
|
|
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| Galanin |
|
GAL1
|
- Agonists: Galanin
- Galanin-like peptide
- Galmic
- Galnon
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|
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GAL2
|
- Agonists: Galanin
- Galanin-like peptide
- Galmic
- Galnon
|
|
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GAL3
|
- Agonists: Galanin
- Galmic
- Galnon
|
|
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| Ghrelin |
- Agonists: Ghrelin
- Capromorelin
- MK-677
- Sermorelin
- SM-130,686
- Tabimorelin
|
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| GnRH |
- Agonists: Buserelin
- Deslorelin
- GnRH
- Goserelin
- Histrelin
- Leuprorelin
- Nafarelin
- Triptorelin
Antagonists: Abarelix
- Cetrorelix
- Degarelix
- Ganirelix
|
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| MCH |
|
MCH1
|
- Agonists: Melanin concentrating hormone
Antagonists: ATC-0175
- GW-803,430
- NGD-4715
- SNAP-7941
- SNAP-94847
|
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MCH2
|
- Agonists: Melanin concentrating hormone
|
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| Melanocortin |
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MC1
|
- Agonists: alpha-MSH
- Afamelanotide
- BMS-470,539
- Bremelanotide
- Melanotan II
Antagonists: Agouti signalling peptide
|
|
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MC2
|
- Agonists: ACTH
- Cosyntropin
- Tetracosactide
|
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MC3
|
- Agonists: alpha-MSH
- Bremelanotide
- Melanotan II
|
|
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MC4
|
- Agonists: alpha-MSH
- Bremelanotide
- Melanotan II
- PF-00446687
- THIQ
Antagonists: Agouti-related peptide
|
|
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MC5
|
- Agonists: alpha-MSH
- Melanotan II
|
|
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| Neuropeptide S |
- Agonists: Neuropeptide S
Antagonists: SHA-68
|
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| Neuropeptide Y |
|
Y1
|
- Agonists: Neuropeptide Y
- Peptide YY
Antagonists: BIBP-3226
|
|
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Y2
|
- Agonists: Neuropeptide Y
- Peptide YY
Antagonists: BIIE-0246
|
|
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Y4
|
- Agonists: Neuropeptide Y
- Pancreatic polypeptide
- Peptide YY
Antagonists: UR-AK49
|
|
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Y5
|
- Agonists: Neuropeptide Y
- Peptide YY
Antagonists: Lu AA-33810
|
|
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| Neurotensin |
|
NTS1
|
- Agonists: Neurotensin
- Neuromedin N
Antagonists: SR-48692
- SR-142,948
|
|
|
NTS2
|
- Agonists: Neurotensin
Antagonists: Levocabastine
- SR-142,948
|
|
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| Orexin |
|
OX1
|
- Agonists: Orexin-A
Antagonists: Almorexant
- SB-334,867
- SB-408,124
- SB-649,868
- Suvorexant
|
|
|
OX2
|
- Agonists: Orexin-A
Antagonists: Almorexant
- SB-649,868
- Suvorexant
- TCS-OX2-29
|
|
|
| Oxytocin |
- Agonists: Carbetocin
- Demoxytocin
- Oxytocin
- WAY-267,464
Antagonists: Atosiban
- Epelsiban
- L-371,257
- L-368,899
- Retosiban
|
|
| Tachykinin |
|
NK1
|
- Agonists: Substance P
Antagonists: Aprepitant
- Befetupitant
- Casopitant
- CI-1021
- CP-96,345
- CP-99,994
- CP-122,721
- Dapitant
- Ezlopitant
- FK-888
- Fosaprepitant
- GR-203,040
- GW-597,599
- HSP-117
- L-733,060
- L-741,671
- L-743,310
- L-758,298
- Lanepitant
- LY-306,740
- Maropitant
- Netupitant
- NKP-608
- Nolpitantium
- Orvepitant
- RP-67,580
- SDZ NKT 343
- Vestipitant
- Vofopitant
|
|
|
NK2
|
- Agonists: Neurokinin A
Antagonists: GR-159,897
- Ibodutant
- Saredutant
|
|
|
NK3
|
- Agonists: Neurokinin B
Antagonists: Osanetant
- Talnetant
|
|
|
| Vasopressin |
|
V1A
|
- Agonists: Desmopressin
- Felypressin
- Ornipressin
- Terlipressin
- Vasopressin
Antagonists: Conivaptan
- Demeclocycline
- Relcovaptan
|
|
|
V1B
|
- Agonists: Felypressin
- Ornipressin
- Terlipressin
- Vasopressin
Antagonists: Demeclocycline
- Nelivaptan
|
|
|
V2
|
- Agonists: Desmopressin
- Ornipressin
- Vasopressin
Antagonists: Conivaptan
- Demeclocycline
- Lixivaptan
- Mozavaptan
- Satavaptan
- Tolvaptan
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Different stress-related gene expression in depression and suicide.
- Zhao J1, Qi XR1, Gao SF2, Lu J2, van Wamelen DJ3, Kamphuis W1, Bao AM4, Swaab DF5.
- Journal of psychiatric research.J Psychiatr Res.2015 Sep;68:176-185. doi: 10.1016/j.jpsychires.2015.06.010. Epub 2015 Jun 24.
- OBJECTIVE: Suicide occurs in some, but not all depressed patients. So far, it remains unknown whether the studied stress-related candidate genes change in depression, suicide or both. The prefrontal cortex (PFC) is involved in, among other things, impulse control and inhibitory behavior and plays an
- PMID 26228417
- Family Economic Hardship, Corticotropin-Releasing Hormone Receptor Polymorphisms, and Depressive Symptoms in Rural African-American Youths.
- Chen YF1, Brody GH2.
- The Journal of adolescent health : official publication of the Society for Adolescent Medicine.J Adolesc Health.2015 Aug;57(2):235-40. doi: 10.1016/j.jadohealth.2015.04.022.
- PURPOSE: The purpose of this study was to use pooled data from two independent studies of rural African-American youths to test the moderation effect of the corticotropin-releasing hormone receptor 1 gene (CRHR1) on the link between family economic hardship and trajectories of depressive symptoms.ME
- PMID 26206446
- Identification of Early-Onset Preeclampsia-Related Genes and MicroRNAs by Bioinformatics Approaches.
- Song J1, Li Y2, An RF3.
- Reproductive sciences (Thousand Oaks, Calif.).Reprod Sci.2015 Aug;22(8):954-63. doi: 10.1177/1933719115570898. Epub 2015 Feb 24.
- BACKGROUND: Early-onset preeclampsia (EOPET), resulting in intrauterine growth restriction, has serious impact on maternal, perinatal, and neonatal livability worldwide. The current study conducted bioinformatics analyses to screen key genes and microRNAs (miRNAs) involved in EOPET and thus to explo
- PMID 25717061
Japanese Journal
- Ectopic ACTH syndrome caused by desmopressin-responsive thymic neuroendocrine tumor
- , , , , , ,
- Endocrine Journal 62(5), 441-447, 2015
- … Her ACTH response was negative to corticotropin-releasing hormone (CRH) and positive to desmopressin. … The resected tumor was pathologically consistent with thymic neuroendocrine tumor (NET) positive for ACTH by immunohistochemistry and abundant V1b receptor gene expression by RT-PCR. …
- NAID 130005071799
- Ectopic ACTH syndrome caused by desmopressin-responsive thymic neuroendocrine tumor
- , , , , , ,
- Endocrine Journal advpub(0), 2015
- … Her ACTH response was negative to corticotropin-releasing hormone (CRH) and positive to desmopressin. … The resected tumor was pathologically consistent with thymic neuroendocrine tumor (NET) positive for ACTH by immunohistochemistry and abundant V1b receptor gene expression by RT-PCR. …
- NAID 130005060863
- Neuropeptide W stimulates adrenocorticotrophic hormone release via corticotrophin-releasing factor but not via arginine vasopressin
- , , , , , , , , ,
- Endocrine Journal 59(7), 547-554, 2012
- … Neuropeptide W (NPW) was isolated as an endogenous ligand for NPBWR1, an orphan G protein-coupled receptor localized in the rat brain, including the paraventricular nucleus. … We hypothesized that NPW activates the hypothalamic-pituitary-adrenal (HPA) axis via corticotrophin-releasing factor (CRF) and/or arginine vasopressin (AVP). …
- NAID 130004443807
Related Links
- Corticotropin-releasing hormone receptorcorticotropin releasing hormone receptor 1IdentifiersSymbolCRHR1Alt. SymbolsCRHREntrez1394HUGO2357OMIM122561RefSeqXM_001128344UniProtP34998Other dataLocusChr. 17 q12 ... ...
- Corticotropin-releasing hormone receptors (CRHRs), also known as corticotropin-releasing factor receptors (CRFRs) are a G protein-coupled receptor family that binds corticotropin-releasing hormone (CRH). There are two receptors in ...
Related Pictures
★リンクテーブル★
[★]
- 関
- corticotropin-releasing factor receptor、corticotropin-releasing hormone receptor、CRH receptor
[★]
- 関
- corticotropin-releasing hormone receptor、CRF receptor
[★]
- 英
- corticotropin-releasing hormone receptor、CRH receptor
- 関
- 副腎皮質刺激ホルモン放出ホルモンレセプター、CRH受容体、CRHレセプター、CRF受容体
[★]
- 英
- corticotropin-releasing hormone receptor、CRH receptor
- 関
- 副腎皮質刺激ホルモン放出ホルモン受容体、CRH受容体、CRHレセプター、CRF受容体
[★]