- 同
- CBG／ transcortin
- 同
- CBG
WordNet
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- a steroid hormone produced by the adrenal cortex or synthesized; administered as drugs they reduce swelling and decrease the bodys immune response; "adrenal cortical steroids are used to treat many different conditions" (同)corticoid, adrenal cortical steroid
- a family of proteins found in blood and milk and muscle and in plant seed
PrepTutorEJDIC
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- グロブリン(動植物組織内の純蛋白(たんぱく)質の総称)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/03 21:41:24」(JST)
[Wiki en表示]
| SERPINA6 |
|
| Available structures |
| PDB |
Ortholog search: PDBe RCSB |
| List of PDB id codes |
|
2VDX, 2VDY, 4BB2, 4C41, 4C49
|
|
|
| Identifiers |
| Aliases |
SERPINA6, CBG, serpin family A member 6 |
| External IDs |
OMIM: 122500 MGI: 88278 HomoloGene: 20417 GeneCards: SERPINA6 |
| Gene ontology |
| Molecular function |
• steroid binding
• serine-type endopeptidase inhibitor activity
• lipid binding
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| Cellular component |
• extracellular region
• extracellular exosome
• extracellular space
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| Biological process |
• glucocorticoid metabolic process
• negative regulation of endopeptidase activity
• transport
|
| Sources:Amigo / QuickGO |
|
| RNA expression pattern |
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
|
|
| Ensembl |
|
|
ENSG00000277405
ENSG00000170099
|
|
|
| UniProt |
|
|
| RefSeq (mRNA) |
|
|
| RefSeq (protein) |
|
|
| Location (UCSC) |
Chr 14: 94.3 – 94.32 Mb |
Chr 12: 103.65 – 103.66 Mb |
| PubMed search |
[1] |
[2] |
| Wikidata |
| View/Edit Human |
View/Edit Mouse |
|
Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is an alpha-globulin.[3][4][5]
Contents
- 1 Function
- 2 Binding
- 3 Synthesis
- 4 Clinical significance
- 5 See also
- 6 References
- 7 Further reading
- 8 External links
Function
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors (serpins) which have evolved by duplication events.[5]
Binding
Transcortin binds several steroid hormones at high rates:
- Cortisol - Approximately 75% of the cortisol in circulation is bound to transcortin. (The rest is bound to serum albumin.) Cortisol is thought to be biologically active only when it is not bound to transcortin.[citation needed]
- Cortisone[6]
- Deoxycorticosterone (DOC)[6]
- Corticosterone - About 78% of serum corticosterone is bound to transcortin.
- Aldosterone - Approximately 17% of serum aldosterone is bound to transcortin, while another 47% is bound to serum albumin. The remaining 36% is free.[7]
- Progesterone - Approximately 18% of serum progesterone is bound to transcortin, while another 80% of it is bound to serum albumin. The remaining 2% is free.[8]
- 17α-Hydroxyprogesterone[6]
In addition, approximately 4% of serum testosterone is bound to transcortin.[9] A similarly small fraction of serum estradiol is bound to transcortin as well.[citation needed]
Synthesis
Transcortin is produced by the liver and is increased by estrogens.[10]
Clinical significance
Mutations in this gene are rare. Only four mutations have been described, often in association with fatigue and chronic pain.[11] This mechanism for these symptoms is not known. This condition must be distinguished from secondary hypocortisolism. Exogenous hydrocortisone does not appear to improve the fatigue.
Hepatic synthesis of corticosteroid-binding globulin more than doubles in pregnancy; that is, unbound plasma cortisol in term pregnancy is approximately 2.5 times that of nonpregnant women.[12]
See also
- Serpin
- Circaseptan, 7-day biological cycle
References
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Hammond GL, Smith CL, Goping IS, Underhill DA, Harley MJ, Reventos J, Musto NA, Gunsalus GL, Bardin CW (August 1987). "Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors". Proc Natl Acad Sci U S A. 84 (15): 5153–7. PMC 298812 . PMID 3299377. doi:10.1073/pnas.84.15.5153.
- ^ Byth BC, Billingsley GD, Cox DW (July 1994). "Physical and genetic mapping of the serpin gene cluster at 14q32.1: allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency". Am J Hum Genet. 55 (1): 126–33. PMC 1918218 . PMID 7912884.
- ^ a b "Entrez Gene: SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6".
- ^ a b c E. Edward Bittar; Neville Bittar (1997). Molecular and Cellular Endocrinology. Elsevier. p. 238. ISBN 978-1-55938-815-3. Retrieved 23 August 2012.
- ^ Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. 24 April 2001. p. 712. ISBN 978-0-7817-1750-2. Retrieved 23 August 2012.
- ^ Negi (2009). Introduction To Endocrinology. PHI Learning Pvt. Ltd. p. 268. ISBN 978-81-203-3850-0. Retrieved 23 August 2012.
- ^ Dunn JF, Nisula BC, Rodbard D (July 1981). "Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma". The Journal of Clinical Endocrinology and Metabolism. 53 (1): 58–68. PMID 7195404. doi:10.1210/jcem-53-1-58.
- ^ Musa BU, Seal US, Doe RP (September 1965). "Elevation of certain plasma proteins in man following estrogen administration: a dose-response relationship". J. Clin. Endocrinol. Metab. 25 (9): 1163–6. PMID 4284083. doi:10.1210/jcem-25-9-1163.
- ^ Torpy DJ, Lundgren BA, Ho JT, Lewis JG, Scott HS, Mericq V (January 2012). "CBG Santiago: a novel CBG mutation". J. Clin. Endocrinol. Metab. 97 (1): E151–5. PMID 22013108. doi:10.1210/jc.2011-2022.
- ^ Rosen MI, Shnider SM, Levinson G, Hughes (2002). Shnider and Levinson's anesthesia for obstetrics. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 13. ISBN 0-683-30665-0.
Further reading
- Rosner W, Beers PC, Awan T, Khan MS (1976). "Identification of corticosteroid-binding globulin in human milk: measurement with a filter disk assay.". J. Clin. Endocrinol. Metab. 42 (6): 1064–73. PMID 932172. doi:10.1210/jcem-42-6-1064.
- Smith CL, Power SG, Hammond GL (1992). "A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol.". J. Steroid Biochem. Mol. Biol. 42 (7): 671–6. PMID 1504007. doi:10.1016/0960-0760(92)90107-T.
- Brotherton J (1990). "Cortisol and transcortin in human seminal plasma and amniotic fluid as estimated by modern specific assays.". Andrologia. 22 (3): 197–204. PMID 2240617. doi:10.1111/j.1439-0272.1990.tb01966.x.
- Seralini GE, Bérubé D, Gagné R, Hammond GL (1991). "The human corticosteroid binding globulin gene is located on chromosome 14q31-q32.1 near two other serine protease inhibitor genes.". Hum. Genet. 86 (1): 73–5. PMID 2253941. doi:10.1007/bf00205177.
- Underhill DA, Hammond GL (1990). "Organization of the human corticosteroid binding globulin gene and analysis of its 5'-flanking region.". Mol. Endocrinol. 3 (9): 1448–54. PMID 2608068. doi:10.1210/mend-3-9-1448.
- Loric S, Egloff M, Domingo M, et al. (1990). "Immunochemical characterization of corticosteroid-binding globulin in human bronchoalveolar fluid.". Clin. Chim. Acta. 186 (1): 19–23. PMID 2612005. doi:10.1016/0009-8981(89)90198-8.
- Heubner A, Belovsky O, Müller W, et al. (1987). "Application of liquid-liquid partition chromatography in the simultaneous purification of sex-hormone-binding globulin and corticosteroid-binding globulin.". J. Chromatogr. 397: 419–34. PMID 2821037. doi:10.1016/S0021-9673(01)85027-5.
- Kato EA, Hsu BR, Kuhn RW (1988). "Comparative structural analyses of corticosteroid binding globulin.". J. Steroid Biochem. 29 (2): 213–20. PMID 3347061. doi:10.1016/0022-4731(88)90268-3.
- Bardin CW, Gunsalus GL, Musto NA, et al. (1988). "Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors.". J. Steroid Biochem. 30 (1-6): 131–9. PMID 3386241. doi:10.1016/0022-4731(88)90085-4.
- Hammond GL, Langley MS (1986). "Identification and measurement of sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) in human saliva.". Acta Endocrinol. 112 (4): 603–8. PMID 3751467. doi:10.1530/acta.0.1120603.
- Agrimonti F, Frairia R, Fornaro D, et al. (1983). "Circadian and circaseptan rhythmicities in corticosteroid-binding globulin (CBG) binding activity of human milk.". Chronobiologia. 9 (3): 281–90. PMID 7172869.
- Misao R, Hori M, Ichigo S, et al. (1995). "Levels of sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) messenger ribonucleic acid (mRNAs) in ovarian endometriosis.". Reprod. Nutr. Dev. 35 (2): 155–65. PMID 7734053. doi:10.1051/rnd:19950204.
- Misao R, Hori M, Ichigo S, et al. (1995). "Corticosteroid-binding globulin mRNA levels in human uterine endometrium.". Steroids. 59 (10): 603–7. PMID 7878688. doi:10.1016/0039-128X(94)90055-8.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Avvakumov GV, Hammond GL (1994). "Glycosylation of human corticosteroid-binding globulin. Differential processing and significance of carbohydrate chains at individual sites.". Biochemistry. 33 (19): 5759–65. PMID 8180202. doi:10.1021/bi00185a012.
- Van Baelen H, Power SG, Hammond GL (1993). "Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93.". Steroids. 58 (6): 275–7. PMID 8212073. doi:10.1016/0039-128X(93)90072-U.
- Misao R, Nakanishi Y, Fujimoto J, et al. (1996). "Expression of corticosteroid-binding globulin mRNA in human uterine endometrial cancers.". Steroids. 60 (10): 720–4. PMID 8539782. doi:10.1016/0039-128X(95)00106-Z.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
External links
- Transcortin at the US National Library of Medicine Medical Subject Headings (MeSH)
- The MEROPS online database for peptidases and their inhibitors: I04.954
- SERPINA6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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Proteins: carrier proteins
|
| Fatty acid |
- FABP1
- FABP2
- FABP3
- FABP4
- FABP5
- FABP6
- FABP7
|
| Hormone |
- peptide hormone: Follistatin
- Growth hormone binding protein
- Insulin-like growth factor binding protein
- IGFBP1
- IGFBP2
- IGFBP3
- IGFBP4
- IGFBP5
- IGFBP6
- IGFBP7
- Neurophysins
- steroid hormone: Sex hormone binding globulin/Androgen binding protein
- Transcortin
- Thyroxine-binding globulin
- Transthyretin
|
| Metal/element |
- calcium
- Calcium-binding protein
- Calmodulin-binding proteins
- copper
- iron
- Iron-binding proteins
- Transferrin receptor
|
| Vitamin |
- Retinol binding protein
- Transcobalamin
|
| Pigment |
- Plant Light-Harvesting Complex
- Orange Carotenoid Protein
- Phycobiliprotein
- Photosynthetic Reaction Centers
- Phytochrome
- Rhodopsin
|
| Other |
- Acyl carrier protein
- Adaptor protein
- Cholesterylester transfer protein
- F-box protein
- GTP-binding protein
- Latent TGF-beta binding protein
- Major urinary proteins
- Membrane transport protein
- Odorant binding protein
|
|
Proteins: Globular proteins
|
| Serum globulins |
|
Alpha globulins
|
|
serpins:
|
- alpha-1 (Alpha 1-antichymotrypsin, Alpha 1-antitrypsin)
- alpha-2 (Alpha 2-antiplasmin)
- Antithrombin (Heparin cofactor II)
|
|
carrier proteins:
|
- alpha-1 (Transcortin)
- alpha-2 (Ceruloplasmin)
- Retinol binding protein
|
|
other:
|
- alpha-1 (Orosomucoid)
- alpha-2 (alpha-2-Macroglobulin, Haptoglobin)
|
|
|
Beta globulins
|
|
carrier proteins:
|
- Sex hormone-binding globulin
- Transferrin
|
|
other:
|
- Angiostatin
- Hemopexin
- Beta-2 microglobulin
- Factor H
- Plasminogen
- Properdin
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|
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Gamma globulin
|
|
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Other
|
- Fibronectin (fFN: Fetal fibronectin)
- Macroglobulin/Microglobulin
- Transcobalamin
|
|
| Other globulins |
- Beta-lactoglobulin
- Thyroglobulin
- Alpha-lactalbumin
- 11S globulin family (seeds)
- 7S globulin family (seeds)
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| Albumins |
|
Egg white
|
- Conalbumin
- Ovalbumin
- Avidin
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Serum albumin
|
- Human serum albumin
- Bovine serum albumin
- Prealbumin
|
|
Other
|
- C-reactive protein
- Lactalbumin (Alpha-lactalbumin)
- Parvalbumin
- Ricin
|
|
- see also disorders of globin and globulin proteins
|
|
Serpins
|
| inhibitory |
- Alpha 1-antichymotrypsin
- Alpha 1-antitrypsin
- Alpha 2-antiplasmin
- Antithrombin
- C1-inhibitor
- Heparin cofactor II
- Protein C inhibitor
- Plasminogen activator inhibitor-1
- Plasminogen activator inhibitor-2
- Protein Z-related protease inhibitor
- SERPINA1
- SERPINA2
- SERPINA3
- SERPINA4
- SERPINA5
- SERPINA6
- SERPINA7
- SERPINA8
- SERPINA9
- SERPINA14
- SERPINB1
- SERPINB2
- SERPINB3
- SERPINB4
- SERPINB5
- SERPINB6
- SERPINB7
- SERPINB8
- SERPINB9
- SERPINB13
- SERPINC1
- SERPIND1
- SERPINE1
- SERPINE2
- SERPINE2
- SERPINF1
- SERPING1
- SERPINH1
- SERPINI1
- SERPINI2
|
| Cross class inhibitory |
|
| noninhibitory |
- Heat shock protein 47
- Maspin
- Ovalbumin
- SERPINF1
- Thyroxine-binding globulin
- Transcortin
- SERPINF1
|
|
see also disorders of globin and globulin proteins
|
|
Protein, glycoconjugate: glycoproteins and glycopeptides
|
| Mucoproteins |
|
Mucin
|
- CD43
- CD164
- MUC1
- MUC2
- MUC3A
- MUC3B
- MUC4
- MUC5AC
- MUC5B
- MUC6
- MUC7
- MUC8
- MUC12
- MUC13
- MUC15
- MUC16
- MUC17
- MUC19
- MUC20
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|
Other
|
- Haptoglobin
- Intrinsic factor
- Orosomucoid
- Peptidoglycan
- Phytohaemagglutinin
- Ovomucin
|
|
| Proteoglycans |
|
CS/DS
|
- Decorin
- Biglycan
- Versican
|
|
HS/CS
|
|
|
CS
|
- Chondroitin sulfate proteoglycans: Aggrecan
- Neurocan
- Brevican
- CD44
- CSPG4
- CSPG5
- Platelet factor 4
- Structural maintenance of chromosomes 3
|
|
KS
|
- Fibromodulin
- Lumican
- Keratocan
|
|
HS
|
|
|
| Other |
- Activin and inhibin
- ADAM
- Alpha 1-antichymotrypsin
- Apolipoprotein H
- CD70
- Asialoglycoprotein
- Avidin
- B-cell activating factor
- 4-1BB ligand
- Cholesterylester transfer protein
- Clusterin
- Colony-stimulating factor
- Hemopexin
- Lactoferrin
- Membrane glycoproteins
- Myelin protein zero
- Osteonectin
- Protein C
- Protein S
- Serum amyloid P component
- Sialoglycoprotein
- CD43
- Glycophorin
- Glycophorin C
- Thrombopoietin
- Thyroglobulin
- Thyroxine-binding proteins
- Transcortin
- Tumor necrosis factor alpha
- Uteroglobin
- Vitronectin
|
|
Glucocorticoid receptor modulators
|
| GR |
| Agonists |
- Cortisol-like and related (16-unsubstituted): 3α,5α-Tetrahydrocorticosterone
- 5α-Dihydrocorticosterone
- 9α-Fluorocortisone (alfluorone)
- 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
- 11-Dehydrocorticosterone acetate
- 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone)
- 11-Deoxycortisol (cortodoxone, cortexolone)
- Cortifen (cortiphen, kortifen)
- Cortodoxone acetate
- 21-Deoxycortisol
- Δ7-Prednisolone
- Δ7-Prednisolone 21-acetate
- Amebucort
- Chloroprednisone
- Cloprednol
- Corticosterone
- Corticosterone acetate
- Corticosterone benzoate
- Cortisol (hydrocortisone)
- Benzodrocortisone (hydrocortisone benzoate)
- Hydrocortamate (hydrocortisone diethylaminoacetate)
- Hydrocortisone esters
- Cortisone
- Deprodone
- Dichlorisone
- Dichlorisone acetate
- Dichlorisone diacetate
- Difluprednate
- Endrisone (endrysone)
- Etiprednol
- Etiprednol dicloacetate (etiprednol dichloroacetate)
- Fludrocortisone (fludrocortone)
- Fluorometholone
- Fluperolone
- Fluprednisolone
- Halopredone
- Halopredone acetate (halopredone diacetate)
- Isoflupredone (9α-fluoroprednisolone)
- Loteprednol
- Mazipredone (depersolone)
- Medrysone
- Methylprednisolone
- Methylprednisolone esters
- Prebediolone
- Prednisolone
- Prednazate
- Prednazoline
- Prednicarbate (prednisolone ethylcarbonate propionate)
- Prednimustine
- Prednisolamate (prednisolone diethylaminoacetate)
- Prednisolone esters
- Prednisone
- Pregnenolone
- Pregnenolone acetate
- Pregnenolone succinate (pregnenolone hemisuccinate)
- Resocortol
- Tipredane
- Tixocortol
- Butixocort (tixocortol butyrate)
- Tixocortol pivalate
- Methasones and related (16-substituted): 16α-Methyl-11-oxoprednisolone
- Alclometasone
- Alclometasone dipropionate
- Amelometasone
- Beclometasone (beclomethasone)
- Betamethasone (betametasone)
- Betamethasone esters
- Cortobenzolone (betamethasone salicylate)
- Ciclometasone (ciclomethasone, cyclomethasone)
- Clobetasol
- Clobetasone
- Clocortolone
- Cloticasone
- Cormetasone (cormethasone)
- Descinolone
- Desoximetasone (desoxymethasone)
- Dexamethasone (dexametasone)
- Diflorasone
- Diflucortolone
- Diflucortolone pivalate
- Diflucortolone valerate
- Dimesone
- Doxibetasol (doxybetasol)
- Fluclorolone
- Flumetasone (flumethasone)
- Flumetasone acetate
- Flumetasone pivalate
- Fluocinolone
- Fluocortin
- Fluocortin butyl (fluocortin butylate)
- Fluocortolone
- Fluprednidene (fluprednylidene)
- Fluticasone
- Fluticasone furoate
- Fluticasone propionate
- Halocortolone
- Halometasone
- Icometasone
- Icometasone enbutate (icometasone butyrate acetate)
- Isoprednidene
- Locicortolone (locicortone)
- Locicortolone dicibate (locicortone dicibate)
- Meclorisone
- Meprednisone (methylprednisone)
- Meprednisone acetate
- Meprednisone hydrogen succinate (methylprednisone hemisuccinate)
- Mometasone
- Paramethasone
- Paramethasone acetate
- Paramethasone disodium phosphate
- Paramethasone phosphate
- Prednylidene
- Prednylidene diethylaminoacetate
- Rimexolone
- Ticabesone
- Timobesone
- Triamcinolone
- Ulobetasol (halobetasol)
- Vamorolone
- Cyclic ketals (16,17-cyclized): Acrocinonide (triamcinolone acroleinide)
- Amcinafal (triamcinolone pentanonide)
- Amcinafide (triamcinolone acetophenide)
- Amcinonide (triamcinolone acetate cyclopentanonide)
- Budesonide
- Ciclesonide
- Cicortonide
- Deflazacort (azacort)
- Descinolone acetonide
- Desonide (hydroxyprednisolone acetonide)
- Desonide disodium phosphate
- Desonide pivalate
- Dexbudesonide
- Drocinonide
- Fluazacort
- Fluclorolone acetonide (flucloronide)
- Fludroxycortide (flurandrenolone, flurandrenolide)
- Flumoxonide
- Flunisolide
- Fluocinolone acetonide
- Ciprocinonide (fluocinolone acetonide cyclopropylcarboxylate)
- Fluocinonide (fluocinolide, fluocinolone acetonide acetate)
- Procinonide (fluocinolone acetonide propionate)
- Formocortal
- Halcinonide
- Itrocinonide
- Rofleponide
- Tralonide
- Triamcinolone acetonide
- Flupamesone (triamcinolone acetonide metembonate)
- Triamcinolone acetonide esters
- Triamcinolone aminobenzal benzamidoisobutyrate (TBI-PAB)
- Triclonide
- Others/atypical (other expanded steroid ring systems, homosteroids, and non-pregnane steroids): Cortisuzol
- Cortivazol
- Domoprednate
- Naflocort
- Nicocortonide
- Nivacortol (nivazol)
- Oxisopred
- RU-28362
- Non-corticosteroids with some glucocorticoid activity: 15β-Hydroxycyproterone acetate
- 17α-Hydroxyprogesterone
- Chlormadinone acetate
- Cyproterone
- Cyproterone acetate
- Delmadinone acetate
- Flugestone
- Flugestone acetate (flurogestone acetate)
- Fluoxymesterone
- Gestodene
- Medrogestone
- Medroxyprogesterone acetate
- Megestrol acetate
- Metribolone
- Norgestomet
- Osaterone acetate
- Progesterone
- Promegestone
- Quingestrone
- Segesterone acetate (nestorone)
- Tetrahydrogestrinone
- Nonsteroidal glucocorticoids: AZD-5423
- GSK-9027
|
| Mixed (SEGRMs) |
- Dagrocorat
- Fosdagrocorat
- Mapracorat
|
| Antagonists |
- 7α-Hydroxy-DHEA
- 17α-Methylprogesterone
- Aglepristone
- Asoprisnil
- Asoprisnil ecamate
- C108297
- C113176
- CORT-108297
- Cyproterone acetate
- Guggulsterone
- Ketoconazole
- Lilopristone
- LLY-2707
- Miconazole
- Mifepristone
- Onapristone
- ORG-34116
- ORG-34517 (SCH-900636)
- ORG-34850
- Pregnenolone 16α-carbonitrile
- RTI 3021–012
- RTI 3021–022
- Telapristone
- Tibolone
- Toripristone
- Ulipristal acetate
|
|
- See also
- Receptor/signaling modulators
- Androgenics
- Estrogenics
- Mineralocorticoidics
- Progestogenics
- Steroid metabolism modulators
- List of corticosteroids
|
|
Mineralocorticoid receptor modulators
|
| MR |
| Agonists |
- 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
- 11-Dehydrocorticosterone acetate
- 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone)
- 11-Deoxycortisol (cortodoxone, cortexolone)
- Cortifen (cortiphen, kortifen)
- Cortodoxone acetate
- 11β-Hydroxyprogesterone
- 16α,18-Dihydroxy-11-deoxycorticosterone
- 17α-Hydroxyaldosterone
- 18-Hydroxy-11-deoxycorticosterone
- 19-Norprogesterone
- Aldosterone
- Corticosterone
- Corticosterone acetate
- Corticosterone benzoate
- Cortisol (hydrocortisone)
- Benzodrocortisone (hydrocortisone benzoate)
- Hydrocortamate (hydrocortisone diethylaminoacetate)
- Hydrocortisone esters
- Cortisone
- Fludrocortisone (fludrocortone)
- Mometasone
- Prednisolone
- Prednazate
- Prednazoline
- Prednicarbate (prednisolone ethylcarbonate propionate)
- Prednimustine
- Prednisolamate (prednisolone diethylaminoacetate)
- Prednisolone esters
- Prednisone
|
| Antagonists |
- Steroidal: 6β-Hydroxy-7α-thiomethylspironolactone
- 7α-Thiomethylspironolactone (SC-26519)
- 7α-Thioprogesterone (SC-8365)
- 7α-Thiospironolactone (SC-24813)
- 16α-Hydroxyprogesterone
- 17α-Hydroxyprogesterone
- 18-Deoxyaldosterone
- Canrenoate potassium (potassium canrenoate)
- Canrenoic acid (canrenoate)
- Canrenone (canrenoate y-lactone)
- Dicirenone
- Dimethisterone
- Drospirenone
- Dydrogesterone
- Eplerenone
- Gestodene
- Guggulsterone
- Medrogestone
- Mespirenone
- Mexrenoate potassium
- Mexrenoic acid (mexrenoate)
- Mexrenone
- Oxprenoic acid (oxprenoate)
- Oxprenoate potassium (RU-28318)
- Pregnenolone
- Progesterone
- Prorenoate potassium
- Prorenoic acid (prorenoate)
- Prorenone
- RO-14-9012
- RU-26752
- SC-5233 (spirolactone)
- SC-8109
- SC-11927 (CS-1)
- SC-19886
- SC-27169
- Spirorenone
- Spironolactone
- Spiroxasone
- Tibolone
- Trimegestone
- ZK-91587
- ZK-97894
- Nonsteroidal: Amlodipine
- Apararenone
- Benidipine
- BR-4628
- Esaxerenone
- Felodipine
- Finerenone
- Nifedipine
- Nimodipine
- Nitrendipine
- PF-03882845
- SM-368229
|
|
- See also
- Receptor/signaling modulators
- Androgenics
- Estrogenics
- Glucocorticoidics
- Progestogenics
- Steroid metabolism modulators
- List of corticosteroids
|
|
Progesterone receptor modulators
|
| PR |
| Agonists |
|
| Mixed (SPRMs) |
- Steroidal: Asoprisnil
- Asoprisnil ecamate
- Guggulsterone
- J1042
- LG-120838
- Mifepristone
- ORG-31710
- ORG-33628
- Telapristone
- Ulipristal acetate
- Vilaprisan
- ZK-137316
- Nonsteroidal: Apigenin
- Kaempferol
- LG-120920
- Naringenin
- PRA-910
- Syringic acid
|
| Antagonists |
- Steroidal: Aglepristone
- Lilopristone
- Lonaprisan
- Onapristone
- RTI 3021–022
- Toripristone
- Zanoterone
- Nonsteroidal: LG001447
- LG-100127
- LG-100128
- LG-120830
- LG-121046
- Valproic acid
- ZM-150271
- ZM-172406
|
|
mPR
(PAQR) |
| Agonists |
- 5α-Dihydroprogesterone
- 5β-Dihydroprogesterone
- 11-Deoxycortisone (21-hydroxyprogesterone)
- 11-Deoxycortisol (17α,21-dihydroxyprogesterone)
- 17α-Hydroxyprogesterone
- Allopregnanolone
- Mifepristone
- Pregnenolone
- Progesterone
|
| Antagonists |
|
|
- See also
- Receptor/signaling modulators
- Androgenics
- Estrogenics
- Glucocorticoidics
- Mineralocorticoidics
- Steroid metabolism modulators
- List of steroidal progestogens
|
UpToDate Contents
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English Journal
- Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery.
- Gibbison B, Angelini GD, Lightman SL.SourceDepartment of Cardiac Anaesthesia, Bristol Heart Institute, Bristol, UK.
- British journal of anaesthesia.Br J Anaesth.2013 Sep;111(3):347-60. doi: 10.1093/bja/aet077. Epub 2013 May 9.
- The hypothalamic-pituitary-adrenal (HPA) axis is a neuro-endocrine system that regulates circulating levels of glucocorticoid hormones. These hormones are vital for normal homeostasis and play a pivotal role in the response to stress. Levels of cortisol fluctuate throughout the day in a diurnal rhyt
- PMID 23661405
- Comparison of Total Cortisol, Free Cortisol, and Surrogate Markers of Free Cortisol in Diagnosis of Adrenal Insufficiency in Patients with Stable Cirrhosis.
- Fede G, Spadaro L, Tomaselli T, Privitera G, Scicali R, Vasianopoulou P, Thalassinos E, Martin N, Thomas M, Purrello F, Burroughs AK.SourceThe Royal Free Sheila Sherlock Liver Centre and University Department of Surgery - University College London and Royal Free Hospital, London, UK; Department of "Biomedicina clinica e molecolare", University of Catania - Garibaldi Hospital, Catania, Italy. Electronic address: g_fede@tiscali.it.
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.Clin Gastroenterol Hepatol.2013 Aug 23. pii: S1542-3565(13)01230-5. doi: 10.1016/j.cgh.2013.08.028. [Epub ahead of print]
- BACKGROUND AND AIMS: Measurements of serum levels of total cortisol can overestimate the prevalence of adrenal dysfunction in patients with cirrhosis, because they have low concentrations of cortisol-binding globulin (CBG) and albumin. We used measurements of serum total cortisol and serum free cort
- PMID 23978347
- ¹⁵N metabolic labeling: evidence for a stable isotope effect on plasma protein levels and peptide chromatographic retention times.
- Webhofer C, Zhang Y, Brusis J, Reckow S, Landgraf R, Maccarrone G, Turck CW, Filiou MD.SourceProteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, Germany.
- Journal of proteomics.J Proteomics.2013 Aug 2;88:27-33. doi: 10.1016/j.jprot.2012.12.013. Epub 2012 Dec 30.
- Many quantitative proteomics methods rely on protein and peptide labeling with stable isotopes. We have recently found that the introduction of ¹⁵N into organisms via in vivo metabolic labeling affects protein expression levels as well as metabolic pathways and behavioral phenotypes. Here, we pre
- PMID 23279933
Japanese Journal
- コルチコステロイド結合蛋白(CBG) (広範囲 血液・尿化学検査 免疫学的検査(第7版・4)その数値をどう読むか) -- (内分泌学的検査 副腎皮質関係)
- ヒト胎盤における Corticosteroid-Binding Globulin の発現
Related Links
- corticosteroid-binding globulin n. See transcortin. corticosteroid-binding globulin. See transcortin. SERPINA6 SERPINA6 A gene on chromosome 14q32.1 that encodes an alpha-globulin with corticosteroid-binding properties, which is ...
- Corticosteroid-binding globulin definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! Added to Favorites ...
Related Pictures
★リンクテーブル★
[★]
-CBG
- 関
- See Corticosteroid-binding globulin
- 関
- cortisol binding globulin
-transcortin
- 同
- corticosteroid-binding globulin
[★]
- 同
- corticosteroid-binding globulin
[★]
- 同
- corticosteroid-binding globulin
[★]
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union
[★]
コルチコイド
- 関
- glucocorticoid, glucocorticoids
[★]
- 関
- globule、globulus、spherule