English Journal
- [Impacts of high-dose methylprednisolone on gene expression profiling in acute spinal cord injury].
- Huang Y1, Wang H, Zhang C, Wang B, Huang H, Zhao X.
- Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi.2011 Mar;25(3):327-33.
- OBJECTIVE: Methylprednisolone (MP) is the only active drug for acute spinal cord injury (SCI), but the molecular mechanism is still further studied. To investigate the pathophysiology of SCI and the molecular mechanism of MP in treating SCI.METHODS: Nine rabbits were randomly divided into 3 groups,
- PMID 21500587
- Diverging effects of cortistatin and somatostatin on the production and release of prostanoids from rat cortical microglia and astrocytes.
- Dello Russo C1, Lisi L, Navarra P, Tringali G.
- Journal of neuroimmunology.J Neuroimmunol.2009 Aug 18;213(1-2):78-83. doi: 10.1016/j.jneuroim.2009.05.016. Epub 2009 Jun 23.
- Here we compared the effects of cortistatin and somatostatin on the production of prostanoids from primary cultures of rat cortical microglia and astrocytes. We found that both cortistatin and somatostatin do not modify basal PGE(2) release from cultured astrocytes in 24-h experiments. Somatostatin
- PMID 19552966
- Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis.
- Malik L1, Kelly NM, Ma JN, Currier EA, Burstein ES, Olsson R.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2009 Mar 15;19(6):1729-32. doi: 10.1016/j.bmcl.2009.01.085. Epub 2009 Jan 30.
- A class of small molecules displaying comparable activities with peptide ligands BAM22 and corticostatin-14 at both the human and rhesus monkey MrgX1 and MrgX2 receptors, respectively, was discovered. A comparative study to compare solid-phase and solution-phase chemistries for the efficient synthes
- PMID 19230660
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★リンクテーブル★
| リンク元 | 「デフェンシン」「コルチコスタチン」 |
「デフェンシン」
- 好中球のアズール顆粒中にはあるが、マクロファージのアズール顆粒中にはない (SMB.39)
- 広い抗菌スペクトルをもつ
- グラム陰性菌、グラム陽性菌、真菌、エンベロープウイルス (SMB.39)
- 30残基の塩基性ペプチド (SMB.39)
- 進化的に保存されている
「コルチコスタチン」
- 英
- corticostatin
- 関
- デフェンシン