corticorelin

Corticorelin
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	79804-71-0
ATC code	V04CD04
PubChem	CID 16132344
UNII	305OE8862Y
Chemical data
Formula	C205H339N59O63S
Mol. mass	4670.31 g/mol
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コルチコレリン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/09 21:11:39」(JST)

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Corticorelin is a diagnostic agent. It is a corticotropin-releasing hormone.^[1]

The corticorelin stimulation test helps to differentiate between the etiologies of ACTH-dependent hypercortisolism. It is used to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.

If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of Cushing's disease is achieved (ACTH of pituitary origin).
If corticorelin injection leads to little or no response in plasma levels of ACTH or cortisol, a diagnosis of Ectopic ACTH syndrome is confirmed.

References

^ Andoh K, Kimura T, Saeki I, et al (June 1994). "General pharmacological properties of the human corticotropin-releasing hormone corticorelin (human)". Arzneimittelforschung 44 (6): 715–26. PMID 8053970.

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English Journal

Cellular signaling protective against noise-induced hearing loss - A role for novel intrinsic cochlear signaling involving corticotropin-releasing factor?

Vetter DE1.
Biochemical pharmacology.Biochem Pharmacol.2015 Sep 1;97(1):1-15. doi: 10.1016/j.bcp.2015.06.011. Epub 2015 Jun 11.
Hearing loss afflicts approximately 15% of the world's population, and crosses all socioeconomic boundaries. While great strides have been made in understanding the genetic components of syndromic and non-syndromic hearing loss, understanding of the mechanisms underlying noise-induced hearing loss (
PMID 26074267

Acute heat stress up-regulates neuropeptide Y precursor mRNA expression and alters brain and plasma concentrations of free amino acids in chicks.

Ito K1, Bahry MA1, Hui Y1, Furuse M1, Chowdhury VS2.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2015 Sep;187:13-9. doi: 10.1016/j.cbpa.2015.04.010. Epub 2015 Apr 29.
Heat stress causes an increase in body temperature and reduced food intake in chickens. Several neuropeptides and amino acids play a vital role in the regulation of food intake. However, the responses of neuropeptides and amino acids to heat-stress-induced food-intake regulation are poorly understoo
PMID 25933935

Cushing's Syndrome Due to CRH and ACTH Co-secreting Pancreatic Tumor-Presentation of a New Case Focusing on Diagnostic Pitfalls.

Fountas A1, Giotaki Z, Ligkros N, Tsakiridou ED, Tigas S, Saeger W, Tsatsoulis A.
Endocrine pathology.Endocr Pathol.2015 Sep;26(3):239-42. doi: 10.1007/s12022-015-9384-5.
Cushing's syndrome (CS) due to a corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH) co-secreting tumor is very rare, and diagnosis can be difficult. We describe a case of CS caused by ectopic CRH and ACTH production from a pancreatic neuroendocrine tumor (pNET) and discuss
PMID 26202047

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[pmid8053970-1] Andoh K, Kimura T, Saeki I, et al (June 1994). "General pharmacological properties of the human corticotropin-releasing hormone corticorelin (human)". Arzneimittelforschung 44 (6): 715–26. PMID 8053970.

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