WordNet

any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

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酵素

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1. 心不全におけるアンギオテンシン変換酵素阻害剤およびアンギオテンシン受容体拮抗剤：作用機序angiotensin converting enzyme inhibitors and receptor blockers in heart failure mechanisms of action [show details]
… Angiotensin converting enzyme (ACE) inhibition is a key component of the medical therapy of heart failure (HF) with systolic dysfunction . Angiotensin II receptor blockers (ARBs) are an alternative to …
2. アンギオテンシン変換酵素阻害剤とアンギオテンシン受容体拮抗剤との相違differences between angiotensin converting enzyme inhibitors and receptor blockers [show details]
…activity. Thus, there is no change in AT2 receptor-mediated effects. Converting enzyme is also a kininase. As a result, inhibiting this enzyme with an ACE inhibitor may lead to increased kinin levels, an effect …
3. 駆出率低下を伴う心不全へのアンジオテンシン変換酵素阻害薬の使用use of angiotensin converting enzyme inhibitors in heart failure with reduced ejection fraction [show details]
… Randomized trials have shown that angiotensin converting enzyme (ACE) inhibitor therapy leads to symptomatic improvement, reduced hospitalization, and enhanced survival in patients with heart failure …
4. 急性心筋梗塞におけるアンギオテンシン変換酵素阻害剤およびアンギオテンシン受容体遮断剤：使用の推奨angiotensin converting enzyme inhibitors and receptor blockers in acute myocardial infarction recommendations for use [show details]
…coronary intervention or fibrinolysis, aspirin, beta blockers, statins, and either angiotensin converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). Most randomized trials of ACE …
5. アンギオテンシン変換酵素阻害剤およびアンギオテンシンII受容体拮抗剤の主な副作用major side effects of angiotensin converting enzyme inhibitors and angiotensin ii receptor blockers [show details]
…may be important: Both kinins and substance P are metabolized by converting enzyme; thus, their levels are increased by converting enzyme inhibition . Kinins, for example, may induce bronchial irritation …

English Journal

Confounders of Cardioprotection by Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting.

Kleinbongard P1, Neuhäuser M, Thielmann M, Kottenberg E, Peters J, Jakob H, Heusch G.
Cardiology.Cardiology.2016;133(2):128-33. doi: 10.1159/000441216. Epub 2015 Nov 5.
OBJECTIVES: Remote ischemic conditioning (RIC) by repetitive blood pressure cuff inflation/deflation around a limb provides cardioprotection in patients undergoing coronary artery bypass grafting (CABG). Cardioprotection is confounded by risk factors, comorbidities and comedications. We aimed to ide
PMID 26536214

Metalloprotein Inhibitors for the Treatment of Human Diseases.

Yang Y, Hu XQ, Li QS, Zhang XX, Ruan BF, Xu J, Liao C1.
Current topics in medicinal chemistry.Curr Top Med Chem.2016;16(4):384-96.
Metalloproteins have attracted momentous attentions for the treatment of many human diseases, including cancer, HIV, hypertension, etc. This article reviews the progresses that have been made in the field of drug development of metalloprotein inhibitors, putting emphasis on the targets of carbonic a
PMID 26268345

Continuation of angiotensin converting enzyme inhibitor therapy, in spite of occurrence of angioedema.

Mahmoudpour SH1, Asselbergs FW2, Terreehorst I3, Souverein PC1, de Boer A1, Maitland-van der Zee AH4.
International journal of cardiology.Int J Cardiol.2015 Dec 15;201:644-5. doi: 10.1016/j.ijcard.2015.08.185. Epub 2015 Aug 25.
PMID 26340133

Japanese Journal

長期間Angiotensin Converting Enzyme阻害薬服用中に発症した致死的血管性浮腫の1例

Journal of UOEH 38(1), 61-64, 2016
NAID 130005132765

Renal Insufficiency in Concert with Renin-angiotensin-aldosterone Inhibition Is a Major Risk Factor for Hyperkalemia Associated with Low-dose Trimethoprim-sulfamethoxazole in Adults