constitutive androstane receptor

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/15 19:49:21」(JST)

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  • Coordinated roles of pregnane x receptor and constitutive androstane receptor in autoinduction of voriconazole metabolism in mice.
  • Ohbuchi M, Yoshinari K, Kaneko H, Matsumoto S, Inoue A, Kawamura A, Usui T, Yamazoe Y.SourceDivision of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Science, Tohoku University, Miyagi, Japan.
  • Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Mar;57(3):1332-8. doi: 10.1128/AAC.01900-12. Epub 2012 Dec 28.
  • The antifungal efficacy of voriconazole (VRC) differs among host species, with potent efficacy in humans but less in rodents. We investigated the possible involvement of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in the species-specific efficacy of VRC through pharmacokinet
  • PMID 23274663
  • Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond.
  • Chai X, Zeng S, Xie W.SourceZhejiang University, College of Pharmaceutical Sciences, Department of Pharmaceutical Analysis and Drug Metabolism , Hangzhou 310058 , China.
  • Expert opinion on drug metabolism & toxicology.Expert Opin Drug Metab Toxicol.2013 Mar;9(3):253-66. doi: 10.1517/17425255.2013.754010. Epub 2013 Jan 17.
  • Introduction: 'Orphan' nuclear receptors belong to the nuclear receptor (NR) superfamily of transcriptional factors. Binding of ligands to these receptors results in the recruitment of the co-activators, thereby regulating the expression of cognate target genes. Areas covered: This review disc
  • PMID 23327618
  • Expression of Human CAR Splicing Variants in BAC-Transgenic Mice.
  • Zhang YK, Lu H, Klaassen CD.SourceDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160.
  • Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2013 Mar;132(1):142-50. doi: 10.1093/toxsci/kfs321. Epub 2012 Nov 14.
  • The nuclear receptor constitutive androstane receptor (CAR) is a key regulator for drug metabolism in liver. Human CAR (hCAR) transcripts are subjected to alternative splicing. Some hCAR splicing variants (SVs) have been shown to encode functional proteins by reporter assays. However, in vivo resear
  • PMID 23152187


  • Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet
  • Takeuchi Kenji,Goto Hirohiko,Ito Yuko [他],Sato Makoto,Matsumoto Satoshi,Senba Tadashi,Yamada Hideyuki,Umehara Ken
  • The Journal of Toxicological Sciences 40(2), 181-191, 2015
  • The effects of the peroxisome proliferator, dehydroepiandrosterone sulfate (DHEAS), and the typical cytochrome P450 (CYP) inducers phenobarbital (PB) and 3-methylcholanthrene (3-MC) on fatty liver wer …
  • NAID 130004904035
  • P1-15-1 卵巣癌に対するConstitutive androstane receptorを介した抗癌剤効果増強,耐性克服に向けての新たな治療戦略(Group 15 卵巣腫瘍・基礎2,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
  • 増山 寿,Wan Yang,延本 悦子,平松 祐司
  • 日本産科婦人科學會雜誌 66(2), 509, 2014-02-01
  • NAID 110009811748
  • Roles of Xenobiotic Receptors in Vascular Pathophysiology
  • Xiao Lei,Zhang Zihui,Luo Xiaoqin
  • Circulation Journal 78(7), 1520-1530, 2014
  • … The pregnane X receptor (PXR) and constitutive androstane receptor (CAR), 2 closely related and liver-enriched members of the nuclear receptor superfamily, and aryl hydrocarbon receptor (AhR), a nonnuclear receptor transcription factor (TF), are major receptors/TFs regulating the expression of genes for the clearance and detoxification of xenobiotics. …
  • NAID 130004926969


6 緒言 Constitutive androstane receptor (CAR; NR1I3)は核内レセプタースーパー ファミリーに属する転写因子であり、肝に多く発現している[1]。CARは細胞内 において主に細胞質に存在し、シャペロンタンパクであるheat shock protein 90 ... is a place to share and follow research. ... The constitutive androstane receptor (CAR; NR1I3) has emerged as one of the main drug- and xenobiotic-sensitive transcriptional regulators. It has a major effect on the ...


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constitutive androstane receptorCAR



constitutive androstane receptor


  [★] 受容体

WordNet   license wordnet

「a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response」

PrepTutorEJDIC   license prepejdic

「=sense organ / 受信装置」





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