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WordNet

resistant to change
a person who is reluctant to accept changes and new ideas (同)conservativist
having social or political views favoring conservatism
(genetics) the process whereby DNA makes a copy of itself before cell division
the repetition of an experiment in order to test the validity of its conclusion; "scientists will not believe an experimental result until they have seen at least one replication"
(law) a pleading made by a plaintiff in reply to the defendants plea or answer
a member of a Conservative Party

PrepTutorEJDIC

(人・考え方などが)『保守的な』・保守主義の / 《C-》保守党の / (見積もり,評価などが)控え目の,穏健な,慎重な / 保守的な人,保守主義者 / 《C-》保守党員
写し,複写,複製 / 《文》(被告の訴答に対する)原告の訴答

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1. 分子遺伝学の原理 principles of molecular genetics
2. エプスタインバーウイルス（EBウイルス）のウイルス学 virology of epstein barr virus
3. 不安定狭心症および非ST上昇型心筋梗塞における保存療法と早期侵襲的治療の比較 trials of conservative versus early invasive therapy in unstable angina and non st elevation myocardial infarction
4. C型肝炎とアルコール hepatitis c and alcohol
5. 遺伝関連研究：原理および応用 genetic association studies principles and applications

English Journal

Gene-based GWAS and biological pathway analysis of the resilience of executive functioning.

Mukherjee S1, Kim S, Ramanan VK, Gibbons LE, Nho K, Glymour MM, Ertekin-Taner N, Montine TJ, Saykin AJ, Crane PK; Alzheimer’s Disease Neuroimaging Initiative.Author information 1Department of Medicine, University of Washington, Box 359780, 325 Ninth Avenue, Seattle, WA, 98104, USA, smukherj@u.washington.edu.AbstractResilience in executive functioning (EF) is characterized by high EF measured by neuropsychological test performance despite structural brain damage from neurodegenerative conditions. We previously reported single nucleotide polymorphism (SNP) genome-wide association study (GWAS) results for EF resilience. Here, we report gene- and pathway-based analyses of the same resilience phenotype, using an optimal SNP-set (Sequence) Kernel Association Test (SKAT) for gene-based analyses (conservative threshold for genome-wide significance = 0.05/18,123 = 2.8 × 10(-6)) and the gene-set enrichment package GSA-SNP for biological pathway analyses (False discovery rate (FDR) < 0.05). Gene-based analyses found a genome-wide significant association between RNASE13 and EF resilience (p = 1.33 × 10(-7)). Genetic pathways involved with dendritic/neuron spine, presynaptic membrane, postsynaptic density, etc., were enriched with association to EF resilience. Although replication of these results is necessary, our findings indicate the potential value of gene- and pathway-based analyses in research on determinants of cognitive resilience.
Brain imaging and behavior.Brain Imaging Behav.2014 Mar;8(1):110-8. doi: 10.1007/s11682-013-9259-7.
Resilience in executive functioning (EF) is characterized by high EF measured by neuropsychological test performance despite structural brain damage from neurodegenerative conditions. We previously reported single nucleotide polymorphism (SNP) genome-wide association study (GWAS) results for EF resi
PMID 24072271

Bovine herpesvirus 5 encodes a unique pattern of microRNAs compared with bovine herpesvirus 1.

Tang Q1, Wu YQ, Chen DS, Zhou Q, Chen HC, Liu ZF.Author information 1State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China.AbstractBovine herpesvirus type 5 (BoHV-5) and bovine herpesvirus 1 (BoHV-1) are two closely related viruses. However, BoHV-5 is responsible for fatal meningitis in calves, while BoHV-1 is associated with infectious rhinotracheitis in cattle, and the mechanism by which the two viruses cause different symptoms is not well understood. In this study, we identified 11 microRNA (miRNA) genes, encoded by the BoHV-5 genome, that were processed into 16 detectable mature miRNAs in productive infection as determined by deep sequencing. We found that 6 out of 16 miRNA genes were present as two copies in the internal repeat and terminal repeat regions, resulting in a total of 17 miRNA-encoding loci distributed in both DNA strands. Surprisingly, BoHV-5 shared only one conservative miRNA with BoHV-1, which was located upstream of the origin of replication. Furthermore, in contrast to BoHV-1, no miRNAs were detected in the unique short region and locus within or near the bovine infected-cell protein 0 and latency-related genes. Variations in both the 5' and 3' ends of the reference sequence were observed, resulting in more than one isoform for each miRNA. All of the 16 miRNAs were detectable by stem-loop reverse transcriptase-PCR. The miRNAs with high read numbers were subjected to Northern blot analysis, and all pre-miRNAs and one mature miRNA were detected. Collectively, the data suggest that BoHV-5 encodes a different pattern of miRNAs, which may regulate the life cycle of BoHV-5 and might account for the different pathogenesis of this virus compared with BoHV-1.
The Journal of general virology.J Gen Virol.2014 Mar;95(Pt 3):671-8. doi: 10.1099/vir.0.061093-0. Epub 2014 Jan 2.
Bovine herpesvirus type 5 (BoHV-5) and bovine herpesvirus 1 (BoHV-1) are two closely related viruses. However, BoHV-5 is responsible for fatal meningitis in calves, while BoHV-1 is associated with infectious rhinotracheitis in cattle, and the mechanism by which the two viruses cause different sympto
PMID 24385436

Survival and cost comparison of kyphoplasty and percutaneous vertebroplasty using german claims data.

Lange A1, Kasperk C, Alvares L, Sauermann S, Braun S.Author information 1*Leibniz University Hannover, Center for Health Economics Research Hannover, Germany †University of Heidelberg, Heidelberg, Germany ‡Spine and Biologics, Medtronic International, Tolochenaz, Switzerland §Spine and Biologics, Medtronic GmbH, Meerbusch, Germany; and ¶Herescon GmbH, Health Economic Research & Consulting, Hannover, Germany.AbstractSTUDY DESIGN: Observational study.
Spine.Spine (Phila Pa 1976).2014 Feb 15;39(4):318-26. doi: 10.1097/BRS.0000000000000135.
STUDY DESIGN: Observational study.OBJECTIVE: Examine the overall survival and treatment costs from a third-party-payer perspective for patients with osteoporotic vertebral compression fractures (OVCFs) treated by vertebral augmentation or conservative treatment in Germany.SUMMARY OF BACKGROUND DATA:
PMID 24299715

Japanese Journal

ヒストンシャペロンCIAによるヌクレオソーム構造変換とエピジェネティクス

夏目亮,栄徳勝光,赤井祐介 [他],佐野徳彦,堀越正美,千田俊哉
生物物理 48(2), 108-113, 2008-03-25
… The histone (H3-H4)_2 tetramer splitting activity of CIA gives new insights into the mechanism of the nucleosome assembly/disassembly, the relationship between nucleosome assembly/disassembly and epigenetic modifications of histones, and the mechanism of the epigenetic information inheritance through the semi-conservative nucleosome replication mode. …
NAID 110006640406