関: C1r complement

WordNet

make complete or perfect; supply what is wanting or form the complement to; "I need some pepper to complement the sweet touch in the soup"
a complete number or quantity; "a full complement"
one of a series of enzymes in the blood serum that are part of the immune response
something added to complete or embellish or make perfect; "a fine wine is a perfect complement to the dinner"; "wild rice was served as an accompaniment to the main dish" (同)accompaniment
number needed to make up a whole force; "a full complement of workers" (同)full complement
a word or phrase used to complete a grammatical construction
either of two parts that mutually complete each other
the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system

PrepTutorEJDIC

(あるものを完全にするため)(…を)補う物(事)《+『of』+『名』》 / 補語(文法で文の成分の一つ) / (必要な)全数,全量;(船の)定員 / …を補足する,補う
carbonの化学記号

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1. 補体系の概要および臨床的評価overview and clinical assessment of the complement system [show details]
… functions of the complement system, the pathways involved, the measurement of complement activity, and the clinical significance of abnormally low or high complement tests.… In complex with C1q are the two proteases C1r and C1s. Upon C1q engagement by antibodies, C1r autoactivates and cleaves C1s,…
2. 補体系の遺伝性疾患inherited disorders of the complement system [show details]
… specific disorders resulting from unregulated complement activity. Deficiencies in the early components of the classical complement pathway (ie, C1q, C1r, C1s, C4, and C2) predispose patients to autoimmune …
3. 補体経路complement pathways [show details]
… refers to the coating of targets with complement ligands to promote their elimination through immune adherence and phagocytosis by cells bearing complement receptors.… C1r, and C1s. The C1q subcomponent has a hydra-like conformation in which two C1r and two C1s molecules (both serine…
4. 補体系の制御因子および受容体regulators and receptors of the complement system [show details]
… inhibitor prevents excessive complement activation on a target, as well as in plasma. C1 inhibitor, a member of the "serpin" superfamily of serine protease inhibitors, binds to each C1r and C1s subcomponent of …
5. 補体系の後天性欠損acquired deficiencies of the complement system [show details]
… Deficiencies in complement proteins may be inherited or acquired (secondary). Secondary causes of complement deficiency will be presented in this topic review. Inherited disorders of the complement system, as well …

English Journal

Tumor cell-derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma.

Riihilä P, Viiklepp K, Nissinen L, Farshchian M, Kallajoki M, Kivisaari A, Meri S, Peltonen J, Peltonen S, Kähäri VM.
The British journal of dermatology. 2019 May;().
Incidence of epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is increasing worldwide. To study the role of complement classical pathway components C1q, C1r and C1s in the progression of cSCC. The mRNA levels of C1Q subunits, C1R and C1S in cSCC cell lines, normal human epider
PMID 31049937

Derivatives of the lectin complement pathway in Lophotrochozoa.

, G G, A A, A A, .
Developmental and comparative immunology. 2019 05;94()35-58.
A plethora of non-overlapping immune molecular mechanisms in metazoans is the most puzzling issue in comparative immunobiology. No valid evolutionary retrospective on these mechanisms has been developed. In this study, we aimed to reveal the origin and evolution of the immune complement-like system
PMID 30682446

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation.

Muia J, Zhu J, Greco SC, Vanhoorelbeke K, Gupta G, Westfield LA, Sadler JE.
Blood. 2019 Apr;133(17)1899-1908.
The metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats member 13) prevents microvascular thrombosis by cleaving von Willebrand factor (VWF) within platelet-rich thrombi, and cleavage depends on allosteric activation of ADAMTS13 by the substrate VWF. Human
PMID 30700419

Japanese Journal

Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation

Inouye Kuniyo,Tomoishi Marie,Yasumoto Makoto [他],Miyake Yuka,Kojima Kenji,Tsuzuki Satoshi,Fushiki Tohru
The journal of biochemistry 153(1), 51-61, 2013-01
… Matriptase is a type II transmembrane serine protease containing two complement proteases C1r/C1s-urchin embryonic growth factor-bone morphogenetic protein domains (CUB repeat) and four low-density lipoprotein receptor class A domains (LDLRA repeat). …
NAID 120005373084

Identification of cDNA Sequences Encoding the Complement Components of Zebrafish (Danio rerio)

Vo Kha Tam,Tsujikura Masakazu,Somamoto Tomonori,Nakano Miki,辻倉正和,杣元智軌,中野実樹
九州大学大学院農学研究院紀要 54(2), 373-387, 2009-10-29
… Zebrafish can be utilized for immunological research as a fish model that allows gene targeting, but lacks enough molecular and sequence information on the complement system, a humoral innate immune factor. … The present study aimed at identification of all the major complement components at the molecular level with phylogenetic evidence. …
NAID 120001766563