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Tas E1, Mahmood B, Garibaldi L, Sperling M.
European journal of pediatrics.Eur J Pediatr.2015 Mar;174(3):403-6. doi: 10.1007/s00431-015-2488-6. Epub 2015 Jan 25.
Stress-related hyperinsulinism (HI) may lead to recalcitrant hypoglycemia for weeks or months following perinatal stress, often in premature newborn infants. Diazoxide is an effective and usually safe medication to treat this type and other types of neonatal HI. We report a male infant born at 35-we
PMID 25618267

Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets.

Kanno A1, Asahara SI2, Masuda K3, Matsuda T4, Kimura-Koyanagi M5, Seino S6, Ogawa W7, Kido Y8.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Feb 14. pii: S0006-291X(15)00241-7. doi: 10.1016/j.bbrc.2015.02.024. [Epub ahead of print]
A high-fat diet (HF) is associated with obesity, insulin resistance, and hyperglycemia. Animal studies have shown compensatory mechanisms in pancreatic β-cells after high fat load, such as increased pancreatic β-cell mass, enhanced insulin secretion, and exocytosis. However, the effects of high fa
PMID 25686499

Fatal congenital hypertrophic cardiomyopathy and a pancreatic nodule morphologically identical to focal lesion of congenital hyperinsulinism in an infant with Costello syndrome: Case report and review of the literature.

Sheffield BS1, Yip S, Ruchelli E, Dunham C, Sherwin E, Brooks PA, Sur A, Singh A, Human D, Patel M, Lee AF.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.Pediatr Dev Pathol.2015 Feb 10. [Epub ahead of print]
Costello syndrome is characterized by constitutional mutations in the proto-oncogene HRAS, causing dysmorphic features, multiple cardiac problems, intellectual disability and an increased risk of neoplasia. We report a male infant with dysmorphic features, born prematurely at 32 weeks, who, during h
PMID 25668678

1) 多嚢胞性卵巣症候群病態解明に向けた総合戦略(シンポジウム3:生殖「多嚢胞性卵巣症候群(PCOS)の病因・病態と管理」,第65回日本産科婦人科学会・学術講演会)

岩瀬明
日本産科婦人科學會雜誌 65(12), 2683-2697, 2013-12-01
… Insulin resistance is defined as a decrease in insulin sensitivity accompanying compensatory hyperinsulinemia and changes in the amount of adipokines secreted from adipose tissue. …
NAID 110009685694