WordNet

join for a common purpose or in a common action; "These forces combined with others"
harvester that heads and threshes and cleans grain while moving across the field
add together from different sources; "combine resources"
of or relating to the pituitary gland; "pituitary hormone"
the master gland of the endocrine system; located at the base of the brain (同)pituitary_gland, pituitary body, hypophysis
the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion
made or joined or united into one

PrepTutorEJDIC

…'を'『結合する』,合同する / …'を'兼ね備える;(…と)…'を'兼ね合わさせる《+『名』+『with』+『名』》 / …'を'化合させる;(…と)…'を'化合させる《+『名』+『with』+『名』》 / 『結合する』,連合する,合同する / (…と)化合する《+『with』+『名』》 / 連合,合同;(特に)企業合同,政治連合 / (また『combine harvester』)(刈り取りと脱穀が同時にできる)複式収穫機,コンバイン
〈U〉〈C〉(…の)(量・額などの)不足,欠乏《+『of』(『in』)+『名』》 / 〈C〉不足分,不足量,不足額 / 〈C〉(精神・肉体などの)欠陥
脳下垂体の(から得られた) / =pituitary gland
ホルモン

UpToDate Contents

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1. 下垂体機能低下症の原因 causes of hypopituitarism
2. 小児における成長ホルモン欠乏症の診断 diagnosis of growth hormone deficiency in children

English Journal

The role of DNA methylation in regulation of the murine Lhx3 gene.

Malik RE1, Rhodes SJ2.Author information 1Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biology, Indiana University-Purdue University Indianapolis, IN, USA; Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: srhodes@iupui.edu.AbstractLHX3 is a LIM-homeodomain transcription factor with critical roles in pituitary and nervous system development. Mutations in the LHX3 gene are associated with pediatric diseases featuring severe hormone deficiencies, hearing loss, developmental delay, and other symptoms. The mechanisms that govern LHX3/Lhx3 transcription are poorly understood. In this study, we examined the role of DNA methylation in the expression status of the mouse Lhx3 gene. Pituitary cells that do not normally express Lhx3 (Pit-1/0 cells) were treated with 5-aza-2'-deoxycytidine, a demethylating reagent. This treatment leads to activation of Lhx3 gene expression suggesting that methylation contributes to Lhx3 regulation. Treatment of Pit-1/0 pituitary cells with a combination of a demethylating reagent and a histone deacetylase inhibitor led to rapid activation of Lhx3 expression, suggesting possible crosstalk between DNA methylation and histone modification processes. To assess DNA methylation levels, treated and untreated Pit-1/0 genomic DNAs were subjected to bisulfite conversion and sequencing. Treated Pit-1/0 cells had decreased methylation at specific sites in the Lhx3 locus compared to untreated cells. Chromatin immunoprecipitation assays demonstrated interactions between the MeCp2 methyl binding protein and Lhx3 promoter regions in the Pit-1/0 cell line. Overall, this study demonstrates that DNA methylation patterns of the Lhx3 gene are associated with its expression status.
Gene.Gene.2014 Jan 25;534(2):272-81. doi: 10.1016/j.gene.2013.10.045. Epub 2013 Oct 31.
LHX3 is a LIM-homeodomain transcription factor with critical roles in pituitary and nervous system development. Mutations in the LHX3 gene are associated with pediatric diseases featuring severe hormone deficiencies, hearing loss, developmental delay, and other symptoms. The mechanisms that govern L
PMID 24183897

Multiple cutaneous hemangiomas in a patient with combined pituitary hormone deficiency.

Aykut A, Ozen S, Sımsek DG, Onay H, Cogulu O, Darcan S, Ozkinay F.AbstractAbstract Combined pituitary hormone deficiency (CPHD) refers to a rare heterogeneous group of conditions in which there is a deficiency in at least two anterior pituitary hormones. Patients with POU1F1 mutations show a combined pituitary deficiency with low or absent levels of growth hormone, prolactin, and thyroid-stimulating hormone. In this study, a 7-month-old girl with a CPHD is presented. She had facial dysmorphologic features, hypertrichosis, and hypotonia. Additionally, she also presented with multiple cutaneous hemangioma that until now has not been reported in association with this disorder.
Journal of pediatric endocrinology & metabolism : JPEM.J Pediatr Endocrinol Metab.2014 Jan 1;27(1-2):171-4. doi: 10.1515/jpem-2013-0208.
Abstract Combined pituitary hormone deficiency (CPHD) refers to a rare heterogeneous group of conditions in which there is a deficiency in at least two anterior pituitary hormones. Patients with POU1F1 mutations show a combined pituitary deficiency with low or absent levels of growth hormone, prolac
PMID 24025721

A novel mutation in SOX3 polyalanine tract: a case of kabuki syndrome with combined pituitary hormone deficiency harboring double mutations in MLL2 and SOX3.

Takagi M1, Ishii T, Torii C, Kosaki K, Hasegawa T.Author information 1Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.AbstractINTRODUCTION: Both duplications encompassing SOX3 and loss-of function mutations in SOX3 have been reported in a minor portion of X-linked isolated growth hormone deficiency (GHD) or combined pituitary hormone deficiency (CPHD) patients with or without mental retardation.
Pituitary.Pituitary.2013 Dec 18. [Epub ahead of print]
INTRODUCTION: Both duplications encompassing SOX3 and loss-of function mutations in SOX3 have been reported in a minor portion of X-linked isolated growth hormone deficiency (GHD) or combined pituitary hormone deficiency (CPHD) patients with or without mental retardation.PATIENTS AND METHODS: We rep
PMID 24346842

Japanese Journal

A Pitfall in the Differential Diagnosis of Hyponatremia

Itoh Naoya,Hozawa Norikazu,Branch Joel
General Medicine 16(2), 107-112, 2015
… Despite thyroid hormone replacement with synthetic thyroxine, the patient had persistent hyponatremia. … Further investigations revealed secondary adrenal insufficiency but otherwise normal pituitary function, based on a rapid adrenocorticotrophic hormone (ACTH) test as part of a combined anterior pituitary stimulation test. … She was diagnosed with isolated ACTH deficiency (IAD) with concomitant Hashimoto's disease. …
NAID 130005078485

Treatment situation of male hypogonadotropic hypogonadism in pediatrics and proposal of testosterone and gonadotropins replacement therapy protocols

Sato Naoko,Hasegawa Tomonobu,Hasegawa Yukihiro,Arisaka Osamu,Ozono Keiichi,Amemiya Shin,Kikuchi Toru,Tanaka Hiroyuki,Harada Shohei,Miyata Ichiro,Tanaka Toshiaki
Clinical Pediatric Endocrinology 24(2), 37-49, 2015
… Male hypogonadotropic hypogonadism (MHH), a disorder associated with infertility, is treated with testosterone replacement therapy (TRT) and/or gonadotropins replacement therapy (GRT) (TRT and GRT, together with HRT hormone replacement therapy). …
NAID 130005069651

Combined pituitary hormone deficiency with unique pituitary dysplasia and morning glory syndrome related to a heterozygous PROKR2 mutation

Asakura Yumi,Muroya Koji,Hanakawa Junko,Sato Takeshi,Aida Noriko,Narumi Satoshi,Hasegawa Tomonobu,Adachi Masanori
Clinical Pediatric Endocrinology 24(1), 27-32, 2015
… p.R248W) in a female patient who had combined pituitary hormone deficiency (CPHD), morning glory syndrome and a severely malformed pituitary gland. … No other mutation was present in 27 genes related to hypogonadotropic hypogonadism, pituitary hormone deficiency and optic nerve malformation. …
NAID 130004853608