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  • Developmental regulation of chicken surfactant protein A and its localization in lung.
  • Zhang W1, Cuperus T1, van Dijk A1, Skjødt K2, Hansen S2, Haagsman HP1, Veldhuizen EJ3.
  • Developmental and comparative immunology.Dev Comp Immunol.2016 Mar 11. pii: S0145-305X(16)30090-8. doi: 10.1016/j.dci.2016.03.010. [Epub ahead of print]
  • Surfactant Protein A (SP-A) is a collagenous C-type lectin (collectin) that plays an important role in the early stage of the host immune response. In chicken SP-A (cSP-A) is expressed as a 26 kDa glycosylated protein in the lung. Using immunohistochemistry, cSP-A protein was detected mainly in the
  • PMID 26976230
  • Crystal structure of a complex of Surfactant Protein D and Haemophilus influenzae lipopolysaccharide reveals shielding of core structures in SP-D resistant strains.
  • Clark HW1, Mackay RM2, Deadman ME3, Hood DW3, Madsen J1, Moxon ER4, Townsend JP2, Reid KB5, Ahmed A6, Shaw AJ6, Greenhough TJ6, Shrive AK7.
  • Infection and immunity.Infect Immun.2016 Mar 7. pii: IAI.01239-15. [Epub ahead of print]
  • The carbohydrate recognition domains (CRDs) of the lung collectin surfactant protein D (SP-D) recognise sugar patterns on the surface of lung pathogens and promote phagocytosis. Using Haemophilus influenzae Eagan strains expressing well-characterised lipopolysaccharide (LPS) surface structures of va
  • PMID 26953329
  • Keratinocyte growth factor supports pulmonary innate immune defense through maintenance of alveolar antimicrobial protein levels and macrophage function.
  • Gardner JC1, Wu H1, Noel JG2, Ramser BJ3, Pitstick L3, Saito A3, Nikolaidis NM3, McCormack FX4.
  • American journal of physiology. Lung cellular and molecular physiology.Am J Physiol Lung Cell Mol Physiol.2016 Feb 26:ajplung.00363.2015. doi: 10.1152/ajplung.00363.2015. [Epub ahead of print]
  • Keratinocyte growth factor (KGF) is an epithelial mitogen that has been reported to protect the lungs from a variety of toxic and infectious insults. In prior studies, we found that recombinant human KGF (rhKGF) accelerates the clearance of bacteria from the murine lung by augmenting the function of
  • PMID 26919897


  • 新規コレクチンは生体防御と形態形成に関与する二重機能性分子である
  • Development of Enzyme-Linked Immunosorbent Assay for Bovine Surfactant Protein D in Bronchoalveolar Lavage Fluid
  • 肺コレクチンによる自然免疫制御機構


Collectins (collagen-containing C-type lectins) are a part of the innate immune system. They form a family of collagenous Ca2+-dependent defense lectins, which are found in animals. Collectins are soluble pattern recognition receptors ...
This thesis is based on nine papers and a review on the collectins and collectin receptors in innate immunity. The collectins are a family of proteins in which the individual chains consist of a C-type lectin domain attached to a collagen domain ...


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  • 生体防御レクチン