WordNet

any enzyme that catalyzes the hydrolysis of collagen and gelatin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/22 23:02:06」(JST)

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Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as Clostridium. They are a considered a virulence factor, facilitating the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs.^[1]

Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell. This stops large structures from forming inside the cell itself.

In addition to being produced by some bacteria, collagenase can be made by the body as part of its normal immune response. This production is induced by cytokines, which stimulate cells such as fibroblasts and osteoblasts, and can cause indirect tissue damage.^{[citation needed]}

Therapeutic uses

Collagenases have been approved for medical uses for

treatment of Dupuytren's contracture (Xiaflex).
wound healing^[2] (Santyl)

Peyronie's disease

Collagenase remains an investigational drug for the treatment of Peyronie's disease. ^[3] It has presented a documented efficiency in reducing the size of plaques or in some cases eliminating them.^[4]

References

^ Gerard J. Tortora, Berdell R. Funke, Cristine L. Case (2007). Microbiology: an introduction. Pearson Benjamin Cummings. ISBN 0-321-39603-0.
^ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501117/
^ http://www.peyronies.org/pages/treatment.htm
^ http://www.andrologyjournal.org/cgi/content/full/30/4/397

External links

Collagenases at the US National Library of Medicine Medical Subject Headings (MeSH)

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UpToDate Contents

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1. ペイロニー病：診断と内科的マネージメント peyronies disease diagnosis and medical management
2. デュピュイトラン拘縮 dupuytrens contracture
3. 変形性関節症の病因 pathogenesis of osteoarthritis
4. 創傷マネージメントの基本原則 basic principles of wound management
5. 慢性関節リウマチにおける滑膜異常 synovial pathology in rheumatoid arthritis

English Journal

PLGA-based microcarriers induce mesenchymal stem cell chondrogenesis and stimulate cartilage repair in osteoarthritis.

Morille M1, Toupet K1, Montero-Menei CN2, Jorgensen C3, Noël D4.
Biomaterials.Biomaterials.2016 May;88:60-9. doi: 10.1016/j.biomaterials.2016.02.022. Epub 2016 Feb 18.
In the present study, we aimed at evaluating the ability of novel PLGA-P188-PLGA-based microspheres to induce the differentiation of mesenchymal stem/stromal cells (MSC) into chondrocytes. To this aim, we tested microspheres releasing TGFβ3 (PAM-T) in vitro and in situ, in a pathological osteoarth
PMID 26945456

In vitro transdifferentiation of human skin keratinocytes to corneal epithelial cells.

Gopakumar V1, Chatterjee N2, Parameswaran S3, Nirmala S4, Krishnakumar S5.
Cytotherapy.Cytotherapy.2016 May;18(5):673-85. doi: 10.1016/j.jcyt.2016.02.005.
BACKGROUND AIMS: Skin keratinocytes (SKs) share the same surface ectodermal origin as that of corneal epithelium. In this study, the plasticity of epidermal keratinocytes was exploited to generate corneal epithelial-like cells, which might serve as an alternative source of autologous tissue for the
PMID 27059204

Enzymatic isolation of viable human odontoblasts.

Cuffaro HM1, Pääkkönen V1, Tjäderhane L1,2.
International endodontic journal.Int Endod J.2016 May;49(5):454-61. doi: 10.1111/iej.12473. Epub 2015 Jun 11.
AIM: To improve an enzymatic method previously used for isolation of rat odontoblasts to isolate viable mature human odontoblasts.METHODOLOGY: Collagenase I, collagenase I/hyaluronidase mixture and hyaluronidase were used to extract mature human odontoblasts from the pulp chamber. Detachment of odon
PMID 26011565

Japanese Journal

新規コラーゲン様ポリペプチドの安定性(耐熱性及び耐酵素性)とヘアケア用途への応用 (特集化粧品の新原料、原料の新機能(2)未来に向く目)

河端良二
Fragrance journal = フレグランスジャーナル 43(4), 50-53, 2015-04
NAID 40020446488

Proanthocyanidin in Red Rice Inhibits MDA-MB-231 Breast Cancer Cell Invasion via the Expression Control of Invasive Proteins

, ,
Biological and Pharmaceutical Bulletin 38(4), 571-581, 2015
… Moreover, PRFR also reduced the activity of collagenase and MMP-9. …
NAID 130005062257

Proanthocyanidin in red rice inhibits MDA-MB-231 breast cancer cell invasion via the expression control of invasive proteins

, ,
Biological and Pharmaceutical Bulletin advpub(0), 2015
… Moreover, PRFR also reduced the activity of collagenase and MMP-9. …
NAID 130004872297

Related Pictures

★リンクテーブル★

リンク元	「コラゲナーゼ」
拡張検索	「fibroblast collagenase」「neutrophil collagenase」「interstitial collagenase」「microbial collagenase」

「コラゲナーゼ」

matrix metallopeptidase 8 (neutrophil collagenase)
Identifiers
Symbol	MMP8
Entrez	4317
HUGO	7175
OMIM	120355
RefSeq	NM_002424
UniProt	P22894
Other data
Locus	Chr. 11 q21-q22

matrix metallopeptidase 1 (interstitial collagenase)
Identifiers
Symbol	MMP1
Entrez	4312
HUGO	7155
OMIM	120353
RefSeq	NM_002421
UniProt	P03956
Other data
Locus	Chr. 11 q21-q22