colchicine

出典: meddic

コルヒチン

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「an analgesic drug derived from the saffron plant and used to treat gout」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/07/12 20:26:13」(JST)

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英文文献

  • YHHU0895, a novel synthetic small-molecule microtubule-destabilizing agent, effectively overcomes P-glycoprotein-mediated tumor multidrug resistance.
  • Zhao H, Quan H, Xie C, Xu Y, Xie F, Hu Y, Lou L.SourceState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Cancer letters.Cancer Lett.2012 Jan 1;314(1):54-62. Epub 2011 Sep 19.
  • P-glycoprotein-mediated multidrug resistance (MDR) is a major limiting factor in the efficacy of most microtubule-targeting agents. Here, we investigated the novel, synthetic, and small-molecule microtubule-destabilizing agent, 2-(2-amino-5-(1-ethyl-1H-indol-5-yl) pyrimidin-4-yl) phenol (YHHU0895),
  • PMID 21982683
  • Epidermolysis bullosa acquisita.
  • Gupta R, Woodley DT, Chen M.AbstractEpidermolysis bullosa acquisita (EBA) is a rare, acquired, chronic subepidermal bullous disease of the skin and mucosa characterized by autoantibodies to type VII collagen (C7) structures, a major component of anchoring fibrils, which attach the epidermis to the dermis. EBA patients have tissue-bound and circulating antitype C7 autoantibodies that attack type C7 and result in a reduction or perturbation of normally functioning anchoring fibrils. Patients with EBA have skin fragility, blisters, erosions, scars, milia, and nail loss, all features reminiscent of genetic dystrophic epidermolysis bullosa. These immunoglobulin G antitype C7 antibodies are pathogenic, because when they are injected into mice, the mice develop an EBA-like blistering disease. In addition to the classical mechanobullous presentation, EBA also has several other distinct clinical syndromes similar to bullous pemphigoid, Brunsting-Perry pemphigoid, or cicatricial pemphigoid. Although treatment for EBA is often unsatisfactory, some therapeutic success has been achieved with colchicine, dapsone, plasmapheresis, photopheresis, infliximab, and intravenous immunoglobulin.
  • Clinics in dermatology.Clin Dermatol.2012 Jan;30(1):60-9.
  • Epidermolysis bullosa acquisita (EBA) is a rare, acquired, chronic subepidermal bullous disease of the skin and mucosa characterized by autoantibodies to type VII collagen (C7) structures, a major component of anchoring fibrils, which attach the epidermis to the dermis. EBA patients have tissue-boun
  • PMID 22137228

和文文献

  • Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever
  • Yasunami Michio,Nakamura Hitomi,Agematsu Kazunaga,Nakamura Akinori,Yazaki Masahide,Kishida Dai,Yachie Akihiro,Toma Tomoko,Masumoto Junya,Ida Hiroaki,Koga Tomohiro,Kawakami Atsushi,Eguchi Katsumi,Furukawa Hiroshi,Nakamura Tadashi,Nakamura Minoru,Migita Kiyoshi
  • PLOS ONE 10(5), e0125938, 2015-05-14
  • … The HLA effects were also assessed for clinical forms of FMF, subsets of FMF with certain MEFV genotypes and responsiveness to colchicine treatment. … Further, 42.9% of 14 colchicine-resistant patients and 13.5% of 156 colchicine-responders possessed B∗35:01 allele, giving OR of 4.82 (p = 0.0041). …
  • NAID 120005615580
  • Urgent Surgical Management of Deep Femoral Artery Aneurysm in a Patient with Pre-Vasculo-Behcet Status
  • Sato Tetsuya,Matsumoto Harunobu,Kimura Naoyuki,Okamura Homore,Adachi Koichi,Yuri Koichi,Yamaguchi Atsushi,Yamada Shigeki,Adachi Hideo
  • Annals of Vascular Diseases 8(2), 116-119, 2015
  • … Remission was achieved with postoperative prednisolone and colchicine without vascular complications. …
  • NAID 130005084197
  • Cytogenetical Investigations in Colchicine-Induced Tetraploids of Brassica fruticulosa: An Important Wild Relative of Cultivated Brassicas
  • Kumar Arun,Singh Binay Kumar,Meena Hari Singh,Ram Bhagirath,Singh Vijay Veer,Singh Dhiraj
  • CYTOLOGIA 80(2), 223-230, 2015
  • … fruticulosa were treated with different concentrations of aqueous colchicine using the cotton-swab method for 8–15 h for 2 to 3 d. … The highest percentage of success was recorded when the seedlings were treated with 0.2% aqueous colchicine for 12 h within 2 d. … However, quadrivalent frequency ranging from 2.28 to 3.14 and univalent frequency ranging from 3.44 to 4.09 per cell were characteristic of the colchicine-induced tetraploids. …
  • NAID 130005074306

関連リンク

コルヒチンを格安でお取扱い!コルヒチンのご購入なら、育毛剤・ED治療薬・ダイエット薬など信頼の格安個人輸入代行のオオサカ堂まで!【送料無料】【100%正規品保証】
Take the missed dose as soon as you remember it. If you are taking colchicine on a regular basis and it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a ...

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★リンクテーブル★
リンク元薬理学」「コルヒチン」「痛風治療薬」「無顆粒球症

薬理学」

  [★]

pharmacology
drug entries


定義

  • 生物系と化学物質の選択的な相互作用を研究する学問 (SPC.2)

生物系と薬の相互作用

  • 薬の生物系に対する相互作用:薬理作用 <-化学の視点
  • 生物系の薬に対する相互作用:薬物動態 <-生物の視点

関連分野

  • 薬物学 materia medica
  • 生薬学
  • 実験薬理学
  • 臨床薬理学
  • 動物薬理学
  • 人体薬理学
  • 比較薬理学
  • 薬理作用学(薬力学)
  • 薬物動態学
  • 中毒学、毒科学
  • 薬物治療学
  • 処方学

薬品の命名

Ending of the drug name Category Example
~afil Erectile dysfunction sildenafil
~ane Inhalatinal general anesthetic halothane
~azepam Benzodiaizepine diazepam
~azine Phenothiazine (neuroleptic, antiemetic) chlorpromazine
~azole Ailtifungal ketoconazole
~barbital Barbiturate phenobarbital
~caine Local anesthetic lidocaine
~cillin Penicillin methicillin
~cycline Antibiotic, protein syntlesis inhibitor tetracycline
~ipramine TCA iimipramine
~navir Protease inhibitor saquinavir
~olol β-antagonist propranolol
~operidol Butyrophenone ( neuroleptic ) haloperidol
~oxin Cardiac glycoside ( inotropic agent ) digoxin
~phylline Methylxanthine theophylline
~pril ACE inhibitor captopril
~terol β2 agonist albuterol
~tidine H2 antagonist cimtidine
~triptyline TCA amitriptyline
~tropine Pituitary hormone somatotropine
~zosin a1 antagonist prazosin

薬一覧

薬物代謝

薬理動態

神経伝達物質

神経筋接合部遮断薬(筋弛緩薬)

交感神経作動薬

アドレナリン受容体

交感神経遮断薬

アドレナリン受容体

副交感神経作動薬

アセチルコリン受容体

副交感神経遮断薬

アセチルコリン受容体

貧血治療薬

甲状腺関連物質

痛風治療薬

  • 痛風発作予防薬
  • 尿酸排泄促進薬
  • 尿酸生成抑制薬


コルヒチン」

  [★]

colchicine
colchicinum
コルヒチン


  • 痛風発作予防薬
   尿酸発作の特効薬、尿酸合成、排泄に関与しない
   好中球の走化因子(LTB4,IL-8)に対する走化性低下
   →炎症部位への遊走を妨げる
   尿酸血症の貪食による脱顆粒の抑制
  副作用
   再生不良貧血、脱毛、下痢
  服用
   発作が起こりそうなときに飲む

禁忌

  • 本剤の成分に対し過敏症の既往歴のある患者
  • 肝臓又は腎臓に障害のある患者で、肝代謝酵素CYP3A4を強く阻害する薬剤又はP糖蛋白を阻害する薬剤を服用中の患者
  • 妊婦又は妊娠している可能性のある婦人



痛風治療薬」

  [★]

arthrifuge, gout suppressant, drug for treatment of gout, antipodagric
抗痛風薬
薬理学痛風
  • 痛風発作予防薬
  • 尿酸排泄促進薬
  • 尿酸生成抑制薬


無顆粒球症」

  [★]

agranulocytosis
ほぼ同
好中球減少症
  • first aid step1 2006 p.





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