コバルトプロト・ルフィリン

WordNet

a hard ferromagnetic silver-white bivalent or trivalent metallic element; a trace element in plant and animal nutrition (同)Co, atomic number 27

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1. 骨髄性プロトポルフィリン症およびX連鎖優性プロトポルフィリン症 erythropoietic protoporphyria and x linked protoporphyria
2. 異型ポルフィリン症 variegate porphyria
3. 小児期の鉛中毒：臨床症状および診断 childhood lead poisoning clinical manifestations and diagnosis
4. 鉄芽球性貧血の臨床的側面、診断、および治療 clinical aspects diagnosis and treatment of the sideroblastic anemias
5. 成人における鉄欠乏性貧血の原因および診断 causes and diagnosis of iron deficiency anemia in the adult

Cobalt Protoporphyrin Upregulates Cyclooxygenase-2 Expression Through a Heme Oxygenase-Independent Mechanism.

Lin HY1, Tsai CH1,2, Lin C3, Yeh WL4, Tsai CF5, Chang PC6, Wu LH7, Lu DY8,9.
Molecular neurobiology.Mol Neurobiol.2016 Sep;53(7):4497-508. doi: 10.1007/s12035-015-9376-y. Epub 2015 Aug 9.
Cobalt protoporphyrin (CoPP) is a potent HO-1 inducer and generally known to be an antioxidant in various cell types. Little is known about the CoPP-induced cyclooxygenase-2 (COX-2) expression and its downstream signaling in microglial cells. In current study, CoPP caused concentration- and time-dep
PMID 26255181

Heme Oxygenase-1 and Carbon Monoxide Promote Burkholderia pseudomallei Infection.

Stolt C1, Schmidt IH1, Sayfart Y1, Steinmetz I2, Bast A1.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2016 Aug 1;197(3):834-46. doi: 10.4049/jimmunol.1403104. Epub 2016 Jun 17.
The environmental bacterium and potential biothreat agent Burkholderia pseudomallei causes melioidosis, an often fatal infectious disease. Increased serum bilirubin has been shown to be a negative predictive factor in melioidosis patients. We therefore investigated the role of heme oxygenase-1 (HO-1
PMID 27316684

Low heme oxygenase-1 levels in patients with systemic sclerosis are associated with an altered Toll-like receptor response: another role for CXCL4?

van Bon L1, Cossu M2, Scharstuhl A3, Pennings BW3, Vonk MC4, Vreman HJ5, Lafyatis RL6, van den Berg W4, Wagener FA3, Radstake TR7.
Rheumatology (Oxford, England).Rheumatology (Oxford).2016 Jul 13. pii: kew251. [Epub ahead of print]
OBJECTIVE: SSc is a disease characterized by inflammation and fibrosis. Heme Oxygenase-1 (HO-1) is a haem-degrading enzyme that mediates resolution of inflammation and is induced upon mediators abundantly present in SSc. We aimed to assess whether HO-1 expression/function is disturbed in SSc patient
PMID 27411481

A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction

Narita Masato,Hatano Etsuro,Ikai Iwao,Miyagawa-Hayashino Aya,Yanagida Atsuko,Nagata Hiromitsu,Asechi Hiroyuki,Taura Kojiro,Uemoto Shinji
Annals of Surgery 249(5), 806-813, 2009-05-00
… METHODS:: Male Sprague-Dawley rats were treated with cobalt protoporphyrin IX (CoPP) or olprinone (OLP), a phosphodiesterase III inhibitor, and hepatic HO-1 expression and HO enzymatic activity were determined. … Zinc protoporphyrin IX (ZnPP), a competitive HO inhibitor, was given to MCT-treated rats together with OLP to clarify the mechanism of protection against SOS. …
NAID 120001479079

Inhibition of ischemia/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1

ANTIOXIDATIVE EFFECT OF SEVERAL PORPHYRINS ON LIPID PEROXIDATION IN RAT LIVER HOMOGENATES

今井公江,相本太刀夫,佐藤正基,木村良平
Chemical & pharmaceutical bulletin 38(1), 258-260, 1990-01-25
… Not only protoporphyrin IX (PP) but also mesoporphyrin IX and hematoporphyrin inhibited the lipid peroxidation. … Some porphyrins, in which 6- and 7- carboxyethyl groups were esterified with a methyl group, such as protoporphyrin IX dimethyl ester and mesoporphyrin IX dimethyl ester, had no antioxidative effect. …
NAID 110003628109