WordNet
- put a coat on; cover the surface of; furnish with a surface; "coat the cake with chocolate" (同)surface
- cover or provide with a coat
- growth of hair or wool or fur covering the body of an animal (同)pelage
- an outer garment that has sleeves and covers the body from shoulder down; worn outdoors
- form a coat over; "Dirt had coated her face" (同)cake
- having or dressed in a coat
- having a coating; covered with an outer layer or film; often used in combination; "coated paper has a smooth polished coating especially suitable for halftone printing"; "sugar-coated pills"
- a small anatomically normal sac or bladderlike structure (especially one containing fluid) (同)cyst
PrepTutorEJDIC
- 『コート』,オーバー,外とう / (男子背広・婦人スーツの)『上着』;(婦人・子供の)長上着 / (動物の)毛,毛皮;(植物の)外被,皮 / 表面をおおうもの;(ペンキ・ニスなどの)塗り;(金属などの)めっき / 〈人〉‘に'上旦を旦せる / 〈ほこりなどが〉〈症など〉'を'『おおう』;(ペンキなどで)〈壁など〉'を'塗る《+『名』+『with』+『名』》
- 小嚢,小胞,小水(気)胞,小空胞
UpToDate Contents
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- 1. 環状皮膚病変が認められる患者に対するアプローチ approach to the patient with annular skin lesions
- 2. 皮膚の水疱を有する患者に対するアプローチ approach to the patient with cutaneous blisters
- 3. 神経筋接合部に作用する毒素の概要 overview of neuromuscular junction toxins
- 4. サル痘 monkeypox
- 5. 水痘帯状疱疹ウイルス感染症の疫学および病因：帯状疱疹 epidemiology and pathogenesis of varicella zoster virus infection herpes zoster
English Journal
- Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: The lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules.
- Xie X, Cho B, Fischer JA.AbstractEpsin is an endocytic protein that binds Clathrin, the plasma membrane, Ubiquitin, and also a variety of other endocytic proteins through well-characterized motifs. Although Epsin is a general endocytic factor, genetic analysis in Drosophila and mice revealed that Epsin is essential specifically for internalization of ubiquitinated transmembrane ligands of the Notch receptor, a process required for Notch activation. Epsin's mechanism of function is complex and context-dependent. Consequently, how Epsin promotes ligand endocytosis and thus Notch signaling is unclear, as is why Notch signaling is uniquely dependent on Epsin. Here, by generating Drosophila lines containing transgenes that express a variety of different Epsin deletion and substitution variants, we tested each of the five protein or lipid interaction modules for a role in Notch activation by each of the two ligands, Serrate and Delta. There are five main results of this work that impact present thinking about the role of Epsin in ligand cells. First, we discovered that deletion or mutation of both UIMs destroyed Epsin's function in Notch signaling and had a greater negative impact on Epsin activity than removal of any other module type. Second, only one of Epsin's two UIMs was essential. Third, the lipid-binding function of the ENTH domain was required only for maximal Epsin activity. Fourth, although the C-terminal Epsin modules that interact with Clathrin, the adapter protein complex AP-2, or endocytic accessory proteins were necessary collectively for Epsin activity, their functions were highly redundant; most unexpected was the finding that Epsin's Clathrin binding motifs were dispensable. Finally, we found that signaling from either ligand, Serrate or Delta, required the same Epsin modules. All of these observations are consistent with a model where Epsin's essential function in ligand cells is to link ubiquitinated Notch ligands to Clathrin-coated vesicles through other Clathrin adapter proteins. We propose that Epsin's specificity for Notch signaling simply reflects its unique ability to interact with the plasma membrane, Ubiquitin, and proteins that bind Clathrin.
- Developmental biology.Dev Biol.2012 Mar 15;363(2):399-412. Epub 2012 Jan 13.
- Epsin is an endocytic protein that binds Clathrin, the plasma membrane, Ubiquitin, and also a variety of other endocytic proteins through well-characterized motifs. Although Epsin is a general endocytic factor, genetic analysis in Drosophila and mice revealed that Epsin is essential specifically for
- PMID 22265678
- Carbohydrate-functionalized surfactant vesicles for controlling the density of glycan arrays.
- Pond MA, Zangmeister RA.SourceMaterial Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, United States.
- Talanta.Talanta.2012 Mar 15;91:134-9. Epub 2012 Jan 24.
- We report on the development of a method for rapidly characterizing the glycan binding properties of lectins. Catanionic surfactant vesicles, prepared from cationic and anionic surfactants, spontaneously formed in water and remained stable at room temperature for months. By varying the amount of gly
- PMID 22365692
Japanese Journal
- CK2 Phosphorylates Sec31 and Regulates ER-To-Golgi Trafficking
- Koreishi Mayuko,Yu Sidney,Oda Mayumi,Honjo Yasuko,Satoh Ayano
- PLoS ONE 8(1), 2013-01-18
- … This is mediated by coat protein II (COPII)-coated vesicles, whose formation requires small GTPase Sar1 and 6 Sec proteins including Sec23 and Sec31. … The initiation and promotion of COPII vesicle formation is regulated by Sar1; … however, the mechanism regulating the completion of COPII vesicle formation followed by vesicle release is largely unknown. …
- NAID 120005311977
- Localization of SMAP2 to the TGN and its Function in the Regulation of TGN Protein Transport
- Funaki Tomo,Kon Shunsuke,Ronn Roger E.,Henmi Yuji,Kobayashi Yuka,Watanabe Toshio,Nakayama Keiko,Tanabe Kenji,Satake Masanobu
- Cell Structure and Function 36(1), 83-95, 2011
- … SMAP2 therefore belongs to an ArfGAP subtype that resides on the TGN and functions as a negative regulator of vesicle budding from the organelle. …
- NAID 130004137566
- Amphiphysin I and regulation of synaptic vesicle endocytosis
- Wu Yumei,Matsui Hideki,Tomizawa Kazuhito
- Acta Medica Okayama 63(6), 305-323, 2009-12
- … Both amphiphysin I and II function as multilinker proteins in the clathrin-coated complex. … Overexpression of the truncated form of amphi-physin I inhibited transferrin uptake and synaptic vesicle endocytosis (SVE). …
- NAID 120002312656
Related Links
- vesicle 1. a small bladder or sac containing liquid. 2. a small circumscribed elevation of the epidermis containing a serous fluid; a small blister. See also vesicular disease. auditory vesicle a detached ovoid sac formed by closure of the ...
- coated vesicle noun Cell Biology. a clathrin-covered vesicle that forms from the closure of a coated pit, engulfing the ligand-receptor complex in endocytosis. Dictionary.com Unabridged Based on the Random House Dictionary ...
Related Pictures
★リンクテーブル★
| リンク元 | 「被覆小胞」「コート小胞」 |
| 拡張検索 | 「COPII-coated vesicle」「COPI-coated vesicle」「COP-coated vesicle」「coatomer-coated vesicle」 |
| 関連記事 | 「coat」「coated」「vesicle」 |
「被覆小胞」
- 英
- 関
- 英
- [[]]
- 同
- coated vesicle
-coated vesicle
「コート小胞」
- 英
- coated vesicle
- 関
- 被覆小胞
「COPII-coated vesicle」
「COPI-coated vesicle」
「COP-coated vesicle」
「coatomer-coated vesicle」
「coat」
- n.
- v.
- コーティングする
「coated」
- 被覆の
「vesicle」
- n.