clozapine

出典: meddic

クロザピン

WordNet   license wordnet

「an antipsychotic drug (trade name Clozaril) used as a sedative and for treatment-resistant schizophrenia; know to have few side effects」
Clozaril

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/09 16:52:42」(JST)

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英文文献

  • Cognitive performance and response inhibition in developmentally vitamin D (DVD)-deficient rats.
  • Turner KM, Young JW, McGrath JJ, Eyles DW, Burne TH.SourceQueensland Brain Institute, The University of Queensland, St. Lucia, Queensland, Australia.
  • Behavioural brain research.Behav Brain Res.2013 Apr 1;242:47-53. doi: 10.1016/j.bbr.2012.12.029. Epub 2012 Dec 27.
  • Evidence from epidemiological studies suggest that low levels of vitamin D during early life alter brain development and may increase the risk of various adverse health outcomes, including schizophrenia. The aim of this experiment was to examine the effect of developmental vitamin D (DVD) deficiency
  • PMID 23275047
  • Electrochemical determination of clozapine on MWCNTs/new coccine doped PPY modified GCE: an experimental design approach.
  • Shahrokhian S, Kamalzadeh Z, Hamzehloei A.SourceDepartment of Chemistry, Sharif University of Technology, Tehran 11155-3516, Iran. shahrokhian@sharif.edu
  • Bioelectrochemistry (Amsterdam, Netherlands).Bioelectrochemistry.2013 Apr;90:36-43. doi: 10.1016/j.bioelechem.2012.10.002. Epub 2012 Nov 7.
  • The electrooxidation of clozapine (CLZ) was studied on the surface of a glassy carbon electrode (GCE) modified with a thin film of multiwalled carbon nanotubes (MWCNTs)/new coccine (NC) doped polypyrrole (PPY) by using linear sweep voltammetry (LSV). The pH of the supporting electrolyte (D), drop si
  • PMID 23178559

和文文献

  • クロザピンの有効性とその臨床的意義
  • 木田 直也,大鶴 卓,福田 貴博 [他]
  • 精神医学 54(11), 1145-1150, 2012-11
  • NAID 40019487372
  • 医療観察法の現状と今後の課題 (特集 医療観察法の現状と今後の課題)
  • 安藤 久美子,永田 貴子,平林 直次
  • 日本精神科病院協会雑誌 31(7), 702-708, 2012-07
  • NAID 40019384375
  • Effects of clozapine and N-desmethylclozapine on synaptic transmission at hippocampal inhibitory and excitatory synapses
  • Ohno-Shosaku Takako,Sugawara Yuto,Muranishi Chiho,Nagasawa Keisuke,Kubono Kozue,Aoki Nami,Taguchi Mitsuki,Echigo Ryousuke,Sugimoto Naotoshi,Kikuchi Yui,Watanabe Ryoko,Yoneda Mitsugu
  • Brain Research 1421, 66-77, 2011-11-03
  • Clozapine is the first atypical antipsychotic, and improves positive and negative symptoms of many patients with schizophrenia resistant to treatment with other antipsychotic agents. … Clozapine induces minimal extrapyramidal side effects, but is more often associated with seizures. … A large number of studies have been conducted to elucidate pharmacological profiles of clozapine and its major active metabolite, N-desmethylclozapine (NDMC). …
  • NAID 120003497598

関連リンク

Clozapine official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. ... Dosage Forms and Strengths Clozapine tablets are available as 25 mg, 50 mg, 100 ...
Clozapine comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken one to three times a day. Take clozapine at around the same time(s) every ...

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★リンクテーブル★
リンク元クロザピン」「prohibitive」「other than」「無顆粒球症

クロザピン」

  [★]

clozapine
Clozaril CLOZARIL
クロザリル
抗精神病薬精神神経用剤
  • first aid step1 2006 p.207,370

特徴

  • 1990年にアメリカで最初に認可、発売された非定形型抗精神病薬。
  • 錐体外路症状を惹起しない。プロラクチンの分泌を昂進させない。定型抗精神病薬に反応不良な症例にも有効
  • 副作用のため、日本では臨床応用されていない。

薬理作用

  • block 5-HT2 receptor and dopamine receptor
  • 抗dopamine作用:弱い
  • 抗D4受容体の選択的アゴニスト

副作用



prohibitive」

  [★]

  • adj.
  • 禁止する、謹製の。(値段が)ひどく高い、(税が)極端に重い。勝利(など)が間違いない
clozapine is generally prescribed only after several other alternative neuroeptic medication have failed, because of the possibility of agranulocytosis and the drug's prohibitive cost.
abstinent, ban, forbid, interdict, prohibit, prohibition, prohibitively

WordNet   license wordnet

「tending to discourage (especially of prices); "the price was prohibitive"」
prohibitory

PrepTutorEJDIC   license prepejdic

「禁止する,禁制の / (価格が)手がでないほど高い;(顔つきなどから)近づきにくい」

other than」

  [★]

patients with a penicillin allergy other than anaphylaxis may receive a cephalosporin.
This serious complication occurs in not more than 1 in 10,000 patients receiving chlorpromazine or other low-potency agents (other than clozapine).

無顆粒球症」

  [★]

agranulocytosis
ほぼ同
好中球減少症
  • first aid step1 2006 p.





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