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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/21 04:22:46」(JST)

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Clorgiline is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research.^[1] It is structurally related to pargyline.

References

^ Murphy, D. L.; Karoum; Pickar; Cohen; Lipper; Mellow; Tariot; Sunderland (1998). "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)". Journal of neural transmission. Supplementum 52: 39–48. doi:10.1007/978-3-7091-6499-0_5. PMID 9564606. edit

English Journal

Synthesis and evaluation of quinazoline amino acid derivatives as mono amine oxidase (MAO) inhibitors.

Khattab SN1, Haiba NS2, Asal AM3, Bekhit AA4, Amer A5, Abdel-Rahman HM6, El-Faham A7.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2015 Apr 16. pii: S0968-0896(15)00319-3. doi: 10.1016/j.bmc.2015.04.021. [Epub ahead of print]
A series of quinazolinone amino acid ester and quinazolinone amino acid hydrazides were prepared under microwave irradiation as well as conventional condition. The microwave irradiation afforded the product in less reaction time, higher yield and purity. The structures of the synthesized compounds w
PMID 25922182

Synthesis, biological investigation and molecular docking study of N-malonyl-1,2-dihydroisoquinoline derivatives as brain specific and shelf-stable MAO inhibitors.

Abd El-Gaber MK1, Hassan HY2, Mahfouz NM2, Farag HH2, Bekhit AA3.
European journal of medicinal chemistry.Eur J Med Chem.2015 Mar 26;93:481-91. doi: 10.1016/j.ejmech.2015.02.039. Epub 2015 Feb 24.
A group of N-malonyl-1,2-dihydroisoquinoline derivatives were synthesized and investigated as brain specific and shelf-stable MAO inhibitors. N-malonyl-1,2-dihydroisoquinoline redox carrier system was linked through amidic bond to 4-chloro and 4-nitrobenzylidenehydrazines (9a-b), as monoamine oxidas
PMID 25732770

Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.

Nirogi R1, Palacharla RC2, Mohammed AR3, Manoharan A2, Ponnamaneni RK2, Bhyrapuneni G2.
Chemico-biological interactions.Chem Biol Interact.2015 Mar 25;230:9-20. doi: 10.1016/j.cbi.2015.01.028. Epub 2015 Feb 3.
The objective of the study was to evaluate the metabolism dependent inhibition of CYP2B6 catalyzed bupropion hydroxylation in human liver microsomes by monoamine oxidase (MAO) inhibitors and to predict the drug-drug interaction potential of monoamine oxidase inhibitors as perpetrators of drug intera
PMID 25656918

Japanese Journal

Unexpected effects of azole transporter inhibitors on antifungal susceptibility in Candida glabrata and other pathogenic Candida species

Nagayoshi Yohsuke,Miyazaki Taiga,Shimamura Shintaro,Nakayama Hironobu,Minematsu Asuka,Yamauchi Shunsuke,Takazono Takahiro,Nakamura Shigeki,Yanagihara Katsunori,Kohno Shigeru,Mukae Hiroshi,Izumikawa Koichi
PLOS ONE 12(7), e0180990, 2017-07-11
… Recently, the monoamine oxidase A (MAO-A) inhibitor clorgyline was shown to inhibit the azole efflux pumps, leading to increased azole susceptibility in C. … In the present study, we have evaluated the effects of clorgyline on susceptibility of C. … The addition of clorgyline to the culture media increased fluconazole susceptibility of a C. … glabrata wild-type strain were highly increased in response to the treatment with clorgyline. …
NAID 120006331923

セロトニン症候群モデルラットにおける筋肉の異常収縮と血漿メタボローム・プロファイルの関連性

財津桂,鈴木廣一,石井晃,野田沙樹,林由美,大原倫美,井口亮,草野麻衣子,佐藤貴子,土橋均,石川哲也
日本毒性学会学術年会 44.1(0), O-38, 2017
… 【実験方法】6週齢のWistar系雄性ラットを投与2時間前から絶食し、5-HTP DMSO溶液、Clorgyline saline溶液を腹腔内投与してモデルを作成した。 …
NAID 130006581873

Inhibition of semicarbazide-sensitive amine oxidase (SSAO) by various antidepressants drugs in monkey platelets

OBATA Toshio
大阪青山大学紀要 = Journal of Osaka Aoyama University (8), 13-18, 2016-03-31
… Two Km values, 100 and 1.38 μM at high and low benzylamines, respectively, were obtained.When the enzyme in platelets was preincubated at 37 °C for 40 min with clorgyline and deprenyl, the deamination of 1 μM benzylamine was not inhibited at high concentrations of these inhibitors, while it was highly sensitive toward semicarbazide. …
NAID 120005905911

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リンク元

「クロルジリン」

Clorgiline
Systematic (IUPAC) name
	N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine
Clinical data
Legal status	Uncontrolled;
Identifiers
CAS Registry Number	17780-72-2
ATC code	None
PubChem	CID: 4380
IUPHAR/BPS	6636
DrugBank	DB04017
ChemSpider	4227
UNII	LYJ16FZU9Q
KEGG	D03248
ChEBI	CHEBI:3763
ChEMBL	CHEMBL8706
Chemical data
Formula	C13H15Cl2NO
Molecular mass	272.17 g/mol
	SMILES Clc1cc(Cl)ccc1OCCCN(CC#C)C;
	InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 ; Key:BTFHLQRNAMSNLC-UHFFFAOYSA-N ;
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　　[★]

英: clorgyline
関: モノアミン酸化酵素阻害薬

[1] Murphy, D. L.; Karoum; Pickar; Cohen; Lipper; Mellow; Tariot; Sunderland (1998). "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)". Journal of neural transmission. Supplementum 52: 39–48. doi:10.1007/978-3-7091-6499-0_5. PMID 9564606. edit

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clorgyline