関: zuclopenthixol

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/03 11:07:02」(JST)

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Clopenthixol (Sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced by Lundbeck in 1961.^[1]

Clopenthixol is a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, was later introduced by Lundbeck in 1962,^[2] and has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.^[3]

Clopenthixol is not approved for use in the United States.

References

^ Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.
^ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 516. ISBN 3-527-31058-4.
^ Gravem A, Engstrand E, Guleng RJ (November 1978). "Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation". Acta Psychiatr Scand 58 (5): 384–8. doi:10.1111/j.1600-0447.1978.tb03570.x. PMID 362830.

External links

Clopenthixol at the US National Library of Medicine Medical Subject Headings (MeSH)

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

English Journal

Possible interaction between letrozole and long-acting injectable zuclopenthixol.

Lertxundi U1, Hernandez R, Albeniz JM, Echaburu SD, Ruiz B, García MG, Aguirre C.
Nordic journal of psychiatry.Nord J Psychiatry.2015 Jan;69(1):79-80. doi: 10.3109/08039488.2014.915341. Epub 2014 May 16.
Mrs A, a 68-year-old woman with paranoid schizophrenia, was on long-term psychiatric treatment with long-acting intramuscular zuclopenthixol, quetiapine and alprazolam when, in April 2012, she was diagnosed with right breast infiltrating ductal carcinoma. After starting treatment with letrozole on 4
PMID 24831298

Treatment of aggressive behavior problems in boys with intellectual disabilities using zuclopenthixol.

Hässler F1, Dück A, Jung M, Reis O.
Journal of child and adolescent psychopharmacology.J Child Adolesc Psychopharmacol.2014 Dec;24(10):579-81. doi: 10.1089/cap.2014.0066.
OBJECTIVE: Disruptive or challenging behavior problems pose a threat to children and adolescents with intellectual disabilities and their caregivers. Psychopharmacological treatment is mostly studied with new-generation antipsychotics and has been criticized for adverse side effects. This study exam
PMID 25514543

[Combination of two depot antipsychotic drugs].

Yazdi K1, Rosenleitner J, Pischinger B.
Der Nervenarzt.Nervenarzt.2014 Jul;85(7):870-1. doi: 10.1007/s00115-013-3759-y.
PMID 23532571

Japanese Journal

Liquid chromatographic analysis of the cis(Z)- and trans(E)-isomers of clopenthixol in human plasma using a novel solid phase extraction procedure

PUCCI Vincenzo,BUGAMELLI Francesca,MANDRIOLI Roberto,BARTOLETTI Claudio,ROSSI Nicola,RAGGI Maria Augusta
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 792(2), 313-321, 2003-07-25
NAID 10016533069

慢性電極植込み無麻酔ネコの行動と脳波による強トランキライザー,ClopenthixolとPerphenazineの比較

西崎弘文 [他]
東邦医学会雑誌 18(1), 95-114, 1971-02-00
NAID 40018140841

慢性精神分裂病に対するClopenthixolの使用経験

飯島尚治 [他]
診療と新薬 2(9), 1125-1131, 1965-09-00
NAID 40017938576

「クロペンチキソール」

Clopenthixol
Systematic (IUPAC) name
	(E,Z)-2-[4-[3-(2-chlorothioxanthen-9-ylidene) propyl]piperazin-1-yl]ethanol
Clinical data
Routes of; administration	Oral
Identifiers
CAS Registry Number	982-24-1
ATC code	N05AF02
PubChem	CID 12454
ChemSpider	11945
UNII	FLE878A8ZI
KEGG	D02613
ChEMBL	CHEMBL53904
Chemical data
Formula	C22H25ClN2OS
Molecular mass	400.965 g/mol
	SMILES Clc2cc1C(c3c(Sc1cc2)cccc3)=CCCN4CCN(CCO)CC4;
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英: clopenthixol
関: ズクロペンチキソール

「zuclopenthixol」

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ズクロペンチキソール

関: clopenthixol

[isbn0-471-89980-1-1] Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.

[isbn3-527-31058-4-2] José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 516. ISBN 3-527-31058-4.

[3] Gravem A, Engstrand E, Guleng RJ (November 1978). "Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation". Acta Psychiatr Scand 58 (5): 384–8. doi:10.1111/j.1600-0447.1978.tb03570.x. PMID 362830.

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clopenthixol