clonal deletion

クローン除去

WordNet

1. the act of deleting something written or printed
2. the omission that is made when an editorial change shortens a written passage; "an editors deletions frequently upset young authors"; "both parties agreed on the excision of the proposed clause" (同)excision, cut
3. (genetics) the loss or absence of one or more nucleotides from a chromosome
4. of or relating to a clone

PrepTutorEJDIC

1. 削除;〈C〉削除箇所

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/08/03 21:18:30」(JST)

wiki en

[Wiki en表示]

Clonal deletion is a process by which B cells and T cells are deactivated after they have expressed receptors for self-antigens and before they develop into fully immunocompetent lymphocytes.

It is one method of immune tolerance.

References

External links

• Clonal+deletion at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 急性骨髄性白血病における細胞遺伝学 cytogenetics in acute myeloid leukemia
• 2. 骨髄異形成症候群の臨床症状および診断 clinical manifestations and diagnosis of the myelodysplastic syndromes
• 3. Idiopathic cytopenias of undetermined significance (ICUS), clonal hematopoiesis of indeterminate potential (CHIP), and clonal cytopenias of undetermined significance (CCUS)
• 4. 先天性の細胞遺伝学的異常 congenital cytogenetic abnormalities
• 5. 本態性血小板血症の予後および治療 prognosis and treatment of essential thrombocythemia

English Journal

• Clonal deleted latent membrane protein 1 variants of Epstein-Barr virus are predominant in European extranodal NK/T lymphomas and disappear during successful treatment.

• Halabi MA1, Jaccard A2, Moulinas R3, Bahri R1, Al Mouhammad H1, Mammari N1, Feuillard J4, Ranger-Rogez S1,5.
• International journal of cancer.Int J Cancer.2016 Aug 15;139(4):793-802. doi: 10.1002/ijc.30128. Epub 2016 Apr 29.
• Extranodal natural killer/T-cell lymphomas (NK/TL), rare in Europe, are Epstein-Barr virus (EBV) associated lymphomas with poor outcomes. Here, we determined the virus type and analyzed the EBV latent membrane protein-1 (LMP1) gene sequence in NK/TL from French patients. Six clones of viral LMP1 wer
• PMID 27061907

• A novel broadly applicable PCR-RFLP method for rapid identification and subtyping of H58 Salmonella Typhi.

• Murgia M1, Rubino S2, Wain J3, Gaind R4, Paglietti B5.
• Journal of microbiological methods.J Microbiol Methods.2016 Aug;127:219-23. doi: 10.1016/j.mimet.2016.06.018. Epub 2016 Jun 16.
• Salmonella Typhi (S. Typhi), the human-adapted agent of typhoid fever, is genetically monomorphic. SNPs accumulation divided the S. Typhi population in 85 haplotypes (H) of which one, H58, has undergone a clonal expansion. The surveillance of H58 S. Typhi is particularly important, especially in are
• PMID 27319376

• Mantle cell lymphoma-variant Richter syndrome: Detailed molecular-cytogenetic and backtracking analysis reveals slow evolution of a pre-MCL clone in parallel with CLL over several years.

• Klener P1,2, Fronkova E3, Berkova A4, Jaksa R5, Lhotska H4, Forsterova K1, Soukup J6, Kulvait V2, Vargova J2, Fiser K3, Prukova D2, Alam M2, Maswabi BC2, Michalova K4, Zemanova Z4, Jancuskova T7, Pekova S7, Trneny M1.
• International journal of cancer.Int J Cancer.2016 Jul 12. doi: 10.1002/ijc.30263. [Epub ahead of print]
• Richter syndrome represents the transformation of the chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most frequently the diffuse large B-cell lymphoma (DLBCL). In this report we describe a patient with CLL, who developed a clonally-related pleomorphic highly-aggressive mantle cell l
• PMID 27407063

Japanese Journal

• Diabetes Insipidus as an Initial Presentation of Myelodysplastic Syndrome: Diagnosis with Single-Nucleotide Polymorphism Array-Based Karyotyping

• The Tohoku Journal of Experimental Medicine 238(4), 305-310, 2016
• NAID 130005145013

• 一過性骨髄異常増殖症における遺伝的多様性

• 臨床血液 56(12), 2434-2440, 2015
• NAID 130005116920

• Functional Mechanism(s) of the Inhibition of Disease Progression by Combination Treatment with Fingolimod Plus Pathogenic Antigen in a Glucose-6-phosphate Isomerase Peptide-Induced Arthritis Mouse Model

• Biological and Pharmaceutical Bulletin 38(8), 1120-1125, 2015
• NAID 130005090637

Related Links

• Clonal deletionとは - goo Wikipedia (ウィキペディア)

Clonal deletionに関するウェブ上の情報を探す English Clonal deletionに関してgoo 辞書で探す Clonal deletionに関する画像を探す English Clonal deletionに関するニュースを探す Clonal deletionに関するQ＆Aを探す

• What does clonal deletion mean? - Definitions.net

Definition of clonal deletion in the Definitions.net dictionary. Meaning of clonal deletion. What does clonal deletion mean? Information and translations of clonal deletion in the most comprehensive dictionary definitions resource on the ...

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リンク元	「クローン除去」
関連記事	「clonal」

「クローン除去」

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英

clonal deletion

同

クローン排除

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クローン除去 : 約 583 件
クローン排除 : 56 件

• 免疫寛容を成立させるメカニズムの1つ。
• 免疫機能の形成時に、自己抗原など特定の抗原に対して反応性を持つ免疫細胞のクローンが能動的に除去される過程。
• 免疫担当細胞(Tリンパ球、Bリンパ球)が発生・分化の過程受ける選択。正常自己構成成分と強く反応する自己反応性レセプターを持った細胞を除去するメカニズム。

参考

• http://www.weblio.jp/content/%E3%82%AF%E3%83%AD%E3%83%BC%E3%83%B3%E9%99%A4%E5%8E%BB
• http://www.med.kindai.ac.jp/immuno/qanda.htm

「clonal」

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• クローンの、クローナルな

関

clone