関: clofedanol hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/01 03:09:10」(JST)

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Clofedanol (INN) or chlophedianol (BAN) is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.^[1] It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009.^[2] Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process^[3] and its safety and efficacy data are limited.

Synthesis

Clofedanol synthesis: R. Lorenz and H. Henecka, U.S. Patent 3,031,377 (1962).

References

^ "Clofedanol" (in French). BIAM. 1998-07-24. Retrieved 2007-04-15.
^ "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Cenrx.com. Retrieved 2009-09-27.
^ "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12.

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English Journal

Stereoselective interaction of drug enantiomers with human serum transferrin in capillary zone electrophoresis (II).

Schmid MG1, Gübitz G, Kilár F.
Electrophoresis.Electrophoresis.1998 Feb;19(2):282-7.
Further studies on chiral resolution of drugs with different chemical structures by capillary zone electrophoresis using iron-free human serum transferrin are described. The substances passed a highly concentrated pseudo-stationary protein zone applied in a coated capillary and the possible chiral s
PMID 9548292

Influence of thyrotropin-releasing hormone on autonomic nervous system determined by the variations in R-R interval on electrocardiogram.

Iwashita A1, Kobayashi I, Inukai T, Takahashi M, Ishii A, Ohshima K, Mori M, Shimomura Y, Kobayashi S.
Experimental and clinical endocrinology.Exp Clin Endocrinol.1990 Sep;96(1):121-4.
The change of variation in R-R interval on electrocardiograms (CVq) was examined in healthy subjects and patients with Graves' disease before and after an intravenous administration of 500 micrograms of Thyrotropin-releasing hormone (TRH). CVq was significantly elevated after TRH stimulation and ret
PMID 2126239

Identification and differentiation of alkylamine antihistamines and their metabolites in urine by computerized gas chromatography-mass spectrometry.

Maurer H1, Pfleger K.
Journal of chromatography.J Chromatogr.1988 Aug 19;430(1):31-41.
A gas chromatographic-mass spectrometric screening procedure is described for the identification and differentiation of the following alkylamine antihistamines and their metabolites in urine: azatadine, benzquinamide, brompheniramine, chlorphenamine, (clofedanol), cyproheptadine, dimetindene, ketoti
PMID 2905706

Japanese Journal

セファクロルおよび総合感冒薬による多剤感作薬疹

松島弘典,大類聡明,今倉樹里子,松浦千華,角田寿之,角田真理
西日本皮膚科 60(5), 671-673, 1998
23歳の女性。初診の約2週間前から感冒様症状のため市販の総合感冒薬2種類を, 10日前から近医内科から処方されたセファクロル, PA錠を, また5日前から塩酸クロフェダノールを処方され内服していた。その後, 熱発と全身のそう痒を伴う紅斑および丘疹を生じ国保旭中央病院皮膚科に入院となった。プレドニゾロンの点滴静注により皮疹は徐々に消退したため, 約10日後に中止し皮疹も略治した。原因薬剤の検討として …
NAID 130004474472

心電図R-R間隔変動幅を指標とした視床下部ホルモンの自律神経系への影響に関する研究:バセドウ病 (Graves'病) 治療経過における検討

岩下章
北関東医学 41(1), 11-20, 1991
… TRH投与により各群において有意の CVqの一過性上昇が認められ, atropine (0.5mg), pirenzepine hydrochrolide (250mg), clofedanol (75mg), 及び hexamethoium bromide (300mg) の前投与により TRHの CVq上昇反応は抑制された。 …
NAID 130003690379

二重盲検法による新鎮咳剤clofedanol hydrochloride錠(SK-74錠)の有用性に関する検討

藤田真之助 [他]
日本胸部臨床 34(2), p150-159, 1975-02
NAID 40002868233

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リンク元	「クロフェダノール」
拡張検索	「clofedanol hydrochloride」

「クロフェダノール」

Chlophedianol
Systematic (IUPAC) name
	1-(2-chlorophenyl)-3-dimethylamino-; 1-phenyl-propan-1-ol
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Oral
Identifiers
CAS Registry Number	791-35-5
ATC code	R05DB10
PubChem	CID 2795
DrugBank	DB04837
ChemSpider	2693
UNII	42C50P12AP
KEGG	D07721
ChEMBL	CHEMBL1201313
Chemical data
Formula	C17H20ClNO
Molecular mass	289.8 g/mol
	SMILES Clc1ccccc1C(O)(c2ccccc2)CCN(C)C;
	InChI InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3 ; Key:WRCHFMBCVFFYEQ-UHFFFAOYSA-N ;
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英: clofedanol
化: 塩酸クロフェダノール clofedanol hydrochloride
商: コルドリン

「clofedanol hydrochloride」

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塩酸クロフェダノール

関: clofedanol

[1] "Clofedanol" (in French). BIAM. 1998-07-24. Retrieved 2007-04-15.

[2] "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Cenrx.com. Retrieved 2009-09-27.

[3] "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12.

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clofedanol