ウンデシル酸クレミゾール
English Journal
- [Thin-layer chromatography of active compounds from ointments and suppositories followed by direct quantitative analysis by remission (author's transl)].
- Amin M, Jakobs U.AbstractThe paper describes a method for simultaneous thin-layer chromatographic separation of hydrocortisone, hydrocortisone acetate or hydrocortisone caproate alongside dibucaine hydrochloride, hexachlorophene and clemizole undecylate as well as clemizole hexachlorophenate in ointments and suppositories. Development of thin-layer chromatograms is carried out on silica gel 60 F-254 pre-coated plates. All four active ingredients can be separated on one silica gel plate using one solvent system and determined directly by the remission method using a densitometer. Hydrocortisone and its two esters are measured at 248 nm, dibucaine hydrochloride at 325 nm, hexachlorophene at 300 nm, and clemizole undecylate as well as clemizole hexachlorophenate at 275 nm. Evaluation of thin-layer chromatograms takes place on-line from a linear calibration curve using an IBM 1800 computer. The described method is very suitable for analyses of these active ingredients in drug forms, such as ointments or suppositories and is reproducible with coefficients of variation of 1.29-3.56%.
- Journal of chromatography.J Chromatogr.1977 Jan 21;131:391-8.
- The paper describes a method for simultaneous thin-layer chromatographic separation of hydrocortisone, hydrocortisone acetate or hydrocortisone caproate alongside dibucaine hydrochloride, hexachlorophene and clemizole undecylate as well as clemizole hexachlorophenate in ointments and suppositories.
- PMID 16026
★リンクテーブル★
[★]
- 英
- clemizole
- 化
- clemizole hydrochloride 塩酸クレミゾール、ウンデシル酸クレミゾール clemizole undecylate
ニュース
- 抗ヒスタミン薬・クレミゾールはHCV感染の治療薬として有望
- 微小流体チップによるC型肝炎ウイルス薬の探索
- Nature Biotechnology 26 (9), Sep 2008
- ………Glenn、Quakeらの研究チームは、HCVの非構造タンパク質4B（NS4B）がHCVのRNAゲノムの結合で役割を担っており、この結合相互作用を阻害すればHCVの複製が抑えられて新たな治療介入法につながるという仮説の検証を始めた。………研究チームは、微小流体装置による小規模の二次スクリーニングで、1,280種の小分子化合物のライブラリーから、NS4BとウイルスRNAの結合を阻害する化合物18種を確認した。そのうち6種は培養細胞で抗ウイルス活性を示し、1種（塩酸クレミゾール）はウイルスの複製を著明に阻害した。NS4B領域またはHCVマイナスRNA鎖の3′末端に変異をもつクレミゾール耐性HCVレプリコンを選択することで、クレミゾールは真のHCV阻害剤であることが確認された。……… (参考)
参考
- http://www.natureasia.com/japan/biotechnology/highlights/article.php?i=68228