塩酸クレミゾール
WordNet
- a complex consisting of an organic base in association with hydrogen chloride
UpToDate Contents
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English Journal
- Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5.
- Richter JM1, Schaefer M1, Hill K2.
- Molecular pharmacology.Mol Pharmacol.2014 Nov;86(5):514-21. doi: 10.1124/mol.114.093229. Epub 2014 Aug 19.
- Canonical transient receptor potential channel 5 (TRPC5) is a nonselective, Ca(2+)-permeable cation channel that belongs to the large family of transient receptor potential channels. It is predominantly found in the central nervous system with a high expression density in the hippocampus, the amygda
- PMID 25140002
- The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors.
- Einav S1, Sobol HD, Gehrig E, Glenn JS.
- The Journal of infectious diseases.J Infect Dis.2010 Jul 1;202(1):65-74. doi: 10.1086/653080.
- BACKGROUND: We recently identified a compound, clemizole hydrochloride, that inhibits NS4B's RNA binding and hepatitis C virus (HCV) replication. Although significant, clemizole's antiviral effect is moderate (50% effective concentration of 8 microM against an HCV genotype 2a clone). We hypothesized
- PMID 20486856
- Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.
- Einav S1, Gerber D, Bryson PD, Sklan EH, Elazar M, Maerkl SJ, Glenn JS, Quake SR.
- Nature biotechnology.Nat Biotechnol.2008 Sep;26(9):1019-27. doi: 10.1038/nbt.1490.
- More effective therapies are urgently needed against hepatitis C virus (HCV), a major cause of viral hepatitis. We used in vitro protein expression and microfluidic affinity analysis to study RNA binding by the HCV transmembrane protein NS4B, which plays an essential role in HCV RNA replication. We
- PMID 18758449
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- Sigma-Aldrich offers Sigma-C5040, Clemizole hydrochloride for your research needs. Find product specific information including CAS, MSDS, protocols and references. ... ANALYTICAL / CHROMATOGRAPHY » Analytical Standards
Related Pictures
★リンクテーブル★
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- 英
- clemizole
- 化
- clemizole hydrochloride 塩酸クレミゾール、ウンデシル酸クレミゾール clemizole undecylate
ニュース
- 抗ヒスタミン薬・クレミゾールはHCV感染の治療薬として有望
- 微小流体チップによるC型肝炎ウイルス薬の探索
- Nature Biotechnology 26 (9), Sep 2008
- ………Glenn、Quakeらの研究チームは、HCVの非構造タンパク質4B(NS4B)がHCVのRNAゲノムの結合で役割を担っており、この結合相互作用を阻害すればHCVの複製が抑えられて新たな治療介入法につながるという仮説の検証を始めた。………研究チームは、微小流体装置による小規模の二次スクリーニングで、1,280種の小分子化合物のライブラリーから、NS4BとウイルスRNAの結合を阻害する化合物18種を確認した。そのうち6種は培養細胞で抗ウイルス活性を示し、1種(塩酸クレミゾール)はウイルスの複製を著明に阻害した。NS4B領域またはHCVマイナスRNA鎖の3′末端に変異をもつクレミゾール耐性HCVレプリコンを選択することで、クレミゾールは真のHCV阻害剤であることが確認された。……… (参考)
参考
- http://www.natureasia.com/japan/biotechnology/highlights/article.php?i=68228
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塩酸塩、ハイドロクロライド