関: clebopride malate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/29 15:11:56」(JST)

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Clebopride is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders. Chemically, it is a substituted benzamide, closely related to metoclopramide.

A small Spanish study found that more adverse reactions are reported with clebopride than with metoclopramide, particularly extrapyramidal symptoms.^[1]

References

^ Cuena Boy R, Maciá Martínez MA (1998). "[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]". Atencion Primaria (in Spanish) 21 (5): 289–95. PMID 9608114. Free full text

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English Journal

[Behavior and functional state of the dopaminergic brain system in pups of depressive WAG/Rij rats].

Malyshev AV, Razumkina EV, Rogozinskaia ÉIa, Sarkisova KIu, Dybynin VA.
Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova.Zh Vyssh Nerv Deiat Im I P Pavlova.2014 May-Jun;64(3):334-46.
In the present work, it has been studied for the first time behavior and functional state of the dopaminergic brain system in pups of "depressive" WAG/Rij rats. Offspring of "depressive" WAG/Rij rats at age of 6-16 days compared with offspring of "normal" (non-depressed) outbred rats of the same age
PMID 25723020

Effect of single and repeated injections of selective D2-antagonist clebopride on maternal behavior of albino rats.

Tanaeva KK1, Dobryakova YV, Dubynin VA, Kamensky AA.
Bulletin of experimental biology and medicine.Bull Exp Biol Med.2012 Jun;153(2):182-5.
This study examined the effect of clebopride at low concentration that did not modify the motor activity on the parental care in female albino rats. Single injection of the drug attenuated the parental care reactions on postinjection minute 20, but not one day thereafter. The daily injection of the
PMID 22816078

Hemi-restless legs syndrome induced by clebopride.

Erro R, Amboni M, Allocca R, Santangelo G, Barone P, Vitale C.
European journal of neurology : the official journal of the European Federation of Neurological Societies.Eur J Neurol.2012 Jun;19(6):e59. doi: 10.1111/j.1468-1331.2012.03716.x.
PMID 22577755

Japanese Journal

Development and validation of a LC-MS/MS method for the determination of clebopride and its application to a pharmacokinetics study in healthy Chinese volunteers

TAN Zhirong,OUYANG Dongsheng,CHEN Yao,ZHOU Gan,CAO Shan,WANG Yicheng,PENG Xiujuan,ZHOU Honghao
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(23), 2072-2076, 2010-08-01
NAID 10028039660

Acute Oculogyric Crisis in a Patient Taking Clebopride

Kim Woojun,Lee Kwang-Soo,Kim Yeong-In,Kim Joong-Seok
Internal Medicine 47(6), 551-552, 2008
… We present a 21-year-old woman with an oculogyric crisis following the administration of clebopride. … Based on the temporal relationship of the administration of clebopride to the occurrence of the event and the absence of other possible etiologies, clebopride is implicated as the cause of this acute oculogyric crisis, despite the fact that a cause-and-effect relationship cannot be confirmed. …
NAID 130000080087

Related Pictures

★リンクテーブル★

リンク元	「クレポプリド」「クレボプリド」
拡張検索	「clebopride malate」

「クレポプリド」

Clebopride
Systematic (IUPAC) name
	4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-; 2-methoxybenzamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	55905-53-8
ATC code	A03FA06
PubChem	CID 2780
ChemSpider	2678
UNII	I0A84520Y9
KEGG	D03534
ChEMBL	CHEMBL325109
Chemical data
Formula	C20H24ClN3O2
Mol. mass	373.876 g/mol
	SMILES Clc1cc(c(OC)cc1N)C(=O)NC3CCN(Cc2ccccc2)CC3;
	InChI InChI=1S/C20H24ClN3O2/c1-26-19-12-18(22)17(21)11-16(19)20(25)23-15-7-9-24(10-8-15)13-14-5-3-2-4-6-14/h2-6,11-12,15H,7-10,13,22H2,1H3,(H,23,25) ; Key:BVPWJMCABCPUQY-UHFFFAOYSA-N ;
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