clathrin heavy chain

• クラスリン重鎖

WordNet

1. unusually great in degree or quantity or number; "heavy taxes"; "a heavy fine"; "heavy casualties"; "heavy losses"; "heavy rain"; "heavy traffic"
2. a serious (or tragic) role in a play
3. an actor who plays villainous roles
4. slowly as if burdened by much weight; "time hung heavy on their hands" (同)heavily
5. requiring or showing effort; "heavy breathing"; "the subject made for labored reading" (同)labored, laboured
6. lacking lightness or liveliness; "heavy humor"; "a leaden conversation" (同)leaden
7. darkened by clouds; "a heavy sky" (同)lowering, sullen, threatening
8. slow and laborious because of weight; "the heavy tread of tired troops"; "moved with a lumbering sag-bellied trot"; "ponderous prehistoric beasts"; "a ponderous yawn" (同)lumbering, ponderous
9. (of sleep) deep and complete; "a heavy sleep"; "fell into a profound sleep"; "a sound sleeper"; "deep wakeless sleep" (同)profound, sound, wakeless
10. full and loud and deep; "heavy sounds"; "a herald chosen for his sonorous voice" (同)sonorous
11. full of; bearing great weight; "trees heavy with fruit"; "vines weighed down with grapes" (同)weighed down
12. (of an actor or role) being or playing the villain; "Iago is the heavy role in `Othello"
13. (physics, chemistry) being or containing an isotope with greater than average atomic mass or weight; "heavy hydrogen"; "heavy water"
14. dense or inadequately leavened and hence likely to cause distress in the alimentary canal; "a heavy pudding"
15. large and powerful; especially designed for heavy loads or rough work; "a heavy truck"; "heavy machinery"
16. made of fabric having considerable thickness; "a heavy coat"
17. marked by great psychological weight; weighted down especially with sadness or troubles or weariness; "a heavy heart"; "a heavy schedule"; "heavy news"; "a heavy silence"; "heavy eyelids"
18. of comparatively great physical weight or density; "a heavy load"; "lead is a heavy metal"; "heavy mahogany furniture"
19. of great intensity or power or force; "a heavy blow"; "the fighting was heavy"; "heavy seas"
20. of relatively large extent and density; "a heavy line"
21. of the military or industry; using (or being) the heaviest and most powerful armaments or weapons or equipment; "heavy artillery"; "heavy infantry"; "a heavy cruiser"; "heavy guns"; "heavy industry involves large-scale production of basic products (such as steel) used by other industries"
22. sharply inclined; "a heavy grade"
23. fasten or secure with chains; "Chain the chairs together"
24. a unit of length
25. a necklace made by a stringing objects together; "a string of beads"; "a strand of pearls"; (同)string, strand
26. a linked or connected series of objects; "a chain of daisies"
27. a series of (usually metal) rings or links fitted into one another to make a flexible ligament
28. anything that acts as a restraint
29. (chemistry) a series of linked atoms (generally in an organic molecule) (同)chemical chain
30. a series of things depending on each other as if linked together; "the chain of command"; "a complicated concatenation of circumstances" (同)concatenation
31. (business) a number of similar establishments (stores or restaurants or banks or hotels or theaters) under one ownership
32. connect or arrange into a chain by linking
33. British biochemist (born in Germany) who isolated and purified penicillin, which had been discovered in 1928 by Sir Alexander Fleming (1906-1979) (同)Ernst Boris Chain, Sir Ernst Boris Chain
34. bound with chains; "enchained demons strained in anger to gnaw on his bones"; "prisoners in chains" (同)enchained

PrepTutorEJDIC

1. 『重い』,重量のある / (分量・程度・規模・強さなどが)『激しい』,大きい, / 『厳しい』,耐えがたい,つらい / 悲しい,陰気な / (動作が)のろい,ぎこちない / ものうい,だるい / (空が)曇った,うっとうしい,(海が)荒れた / (食物が)消化の悪い / 敵役,悪役
2. 『鎖』;(装飾用の)鎖 / 《複数形で》『束縛』,拘束;囚人をつなぐ鎖 / (物事の)『連続』,つながり《+『of』+『名』》 / (商店・銀行・ホテルなどの)チェーン(一連の店が同一資本のもとで連携して経営される方式;その店) / チェーン(測量で用いられる単位;約21.7m) / …'を'『鎖でつなぐ』《+『up』(『together』)+『名,』+『名』+『up』(『together』)》

UpToDate Contents

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• 1. 免疫グロブリン軽鎖（AL）アミロイドーシスおよび軽鎖重鎖沈着症の病因 pathogenesis of immunoglobulin light chain al amyloidosis and light and heavy chain deposition diseases
• 2. 重鎖病 the heavy chain diseases
• 3. 免疫グロブリン軽鎖（AL）アミロイドーシスおよび軽鎖重鎖沈着症の予後および治療 prognosis and treatment of immunoglobulin light chain al amyloidosis and light and heavy chain deposition diseases
• 4. 肥大型心筋症の遺伝学 genetics of hypertrophic cardiomyopathy
• 5. 意義未確定の単クローン性免疫グロブリン血症（MGUS）の診断 diagnosis of monoclonal gammopathy of undetermined significance

English Journal

• Clathrin localization and dynamics in Aspergillus nidulans.

• Schultzhaus Z1, Johnson TB1, Shaw BD1.
• Molecular microbiology.Mol Microbiol.2017 Jan;103(2):299-318. doi: 10.1111/mmi.13557. Epub 2016 Nov 14.
• Cell growth necessitates extensive membrane remodeling events including vesicle fusion or fission, processes that are regulated by coat proteins. The hyphal cells of filamentous fungi concentrate both exocytosis and endocytosis at the apex. This investigation focuses on clathrin in Aspergillus nidul
• PMID 27741567

• Cellular and viral peptides bind multiple sites on the N-terminal domain of clathrin.

• Muenzner J1, Traub LM2, Kelly BT3, Graham SC1.
• Traffic (Copenhagen, Denmark).Traffic.2017 Jan;18(1):44-57. doi: 10.1111/tra.12457. Epub 2016 Dec 14.
• Short peptide motifs in unstructured regions of clathrin-adaptor proteins recruit clathrin to membranes to facilitate post-Golgi membrane transport. Three consensus clathrin-binding peptide sequences have been identified and structural studies show that each binds distinct sites on the clathrin heav
• PMID 27813245

• Entry of severe fever with thrombocytopenia syndrome virus.

• Yuan F1, Zheng A2.
• Virologica Sinica.Virol Sin.2016 Dec 16. [Epub ahead of print]
• Severe fever with thrombocytopenia syndrome virus (SFTSV) is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, i
• PMID 27995422

Japanese Journal

• The class Ⅱ phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells

• Aung Khin Thuzar,Yoshioka Kazuaki,Aki Sho,Ishimaru Kazuhiro,Takuwa Noriko,Takuwa Yoh
• The journal of physiological sciences 69(2), 263-280, 2019-03
• … We performed knockdown studies of endogenous PI3K isoforms and clathrin heavy chain (CHC) mediated by small interfering RNA (siRNA). … Pinocytosis was partially dependent on both clathrin and dynamin, and both PI3K-C2α and PI3K-C2β were required for clathrin-mediated—but not clathrin-non-mediated—FITC-dextran uptake at the step leading up to its delivery to early endosomes. …
• NAID 120006621948

• Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis

• Nakatsuka Atsuko,Matsuyama Makoto,Yamaguchi Satoshi,Katayama Akihiro,Eguchi Jun,Murakami Kazutoshi,Teshigawara Sanae,Ogawa Daisuke,Wada Nozomu,Yasunaka Tetsuya,Ikeda Fusao,Takaki Akinobu,Watanabe Eijiro,Wada Jun
• Scientific Reports (6), 21721, 2016-02-17
• … Pemt exerted inhibitory effects on p53-driven transcription by forming the complex with clathrin heavy chain and p53, and Pemt−/− mice fed HFHS diet demonstrated prominent apoptosis of hepatocytes. …
• NAID 120005728628

• クラスリン重鎖の免疫組織化学染色は食道粘膜内腫瘍の病理組織診断に有用である

• 清宮 正徳,野村 文夫,時田 和也,松下 一之,朝長 毅,谷澤 徹,上里 昌也,島田 英明,松原 久裕,中谷 行雄
• 日本分子腫瘍マーカー研究会誌 29(0), 73-75, 2014
• NAID 130005161445

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★リンクテーブル★

関連記事	「heaving」「heavy」「chain」

「heaving」

　　[★]

• n.

• 揚げること、持ち上げること、引き揚げ。(船体の)上下揺れ。隆起、(地盤の)ふくれあがり、ヒービング

physical findings of LVH may include a heaving lV impulse on chest palpation, indicative of increased muscle mass.(PHD.325)

関

heave

「heavy」

　　[★]

• adj.

比較級heavier-最上級heaviest

• 重い

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「chain」

　　[★]

• n.

• 鎖、チェーン

• adj.

• 鎖状の、鎖式の

関

open-chain、strand