citalopram

出典: meddic




Celexa, Lexapro

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/08/12 10:51:05」(JST)

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英文文献

  • Antidepressants encounter autophagy in neural cells.
  • Zschocke J, Rein T.SourceMax Planck Institute of Psychiatry; Chaperone Research Group; Munich, Germany.
  • Autophagy.Autophagy.2011 Oct 1;7(10). [Epub ahead of print]
  • The prevailing view of antidepressants' (ADs) mode of action primarily focuses on their impact on neurotransmitter circuits, since the corresponding transporters and receptors are common targets of ADs. However, mounting evidence points to additional target structures, which may either support the b
  • PMID 21642768
  • Repeated citalopram administration counteracts kainic acid-induced spreading of PSA-NCAM-immunoreactive cells and loss of reelin in the adult mouse hippocampus.
  • Jaako K, Aonurm-Helm A, Kalda A, Anier K, Zharkovsky T, Shastin D, Zharkovsky A.AbstractSystemic or intracerebral administration of kainic acid in rodents induces neuronal death followed by a cascade of neuroplastic changes in the hippocampus. Kainic acid-induced neuroplasticity is evidenced by alterations in hippocampal neurogenesis, dispersion of the granule cell layer and re-organisation of mossy fibres. Similar abnormalities are observed in patients with temporal lobe epilepsy and, therefore, kainic acid-induced hippocampal neuroplasticity might mimic pathological mechanisms leading to the formation of 'epileptic brain' in patients with temporal lobe epilepsy. Previous studies have demonstrated that selective serotonin re-uptake inhibitor antidepressants might reduce the severity of seizures in epileptic patients and reduce neuronal death in laboratory animal models of kainic acid-induced neurotoxicity. In the present study, we investigated whether kainic acid-induced neuroplasticity in mice is modulated by the repeated administration of citalopram, a selective serotonin reuptake inhibitor. We found that at the histopathological level, repeated citalopram treatment counteracted the kainic acid-induced neuronal loss and dispersion of young granule neurons expressing the polysialylated neural cell adhesion molecule within the granule cell layer of the hippocampus. Citalopram also counteracted the downregulation of reelin on both mRNA and protein levels induced by kainic acid administration. Our findings indicate that repeated administration of citalopram is able to prevent kainic acid-induced abnormal brain plasticity and thereby prevent the formation of an epileptic phenotype.
  • European journal of pharmacology.Eur J Pharmacol.2011 Sep;666(1-3):61-71. Epub 2011 May 11.
  • Systemic or intracerebral administration of kainic acid in rodents induces neuronal death followed by a cascade of neuroplastic changes in the hippocampus. Kainic acid-induced neuroplasticity is evidenced by alterations in hippocampal neurogenesis, dispersion of the granule cell layer and re-organis
  • PMID 21596030

和文文献

  • 高齢女性患者におけるジプラシドンおよびシタロプラムによる遅発性ジスキネジア
  • OZBULUT Omer,EMUL Murat,GULER Ozkan,GECICI Omer
  • Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 8(2), 96-97, 2008-06-01
  • NAID 10027274504
  • Effects of Serotonergic Anxiolytics on the Freezing Behavior in the Elevated Open-Platform Test in Mice
  • MIYATA Shigeo,SHIMOI Toshiko,HIRANO Shoko,YAMADA Naoko,HATA Yoko,YOSHIKAWA Naoki,OHSAWA Masahiro,KAMEI Junzo
  • Journal of pharmacological sciences 105(3), 272-278, 2007-11-20
  • … 8-week-old) were individually placed on an elevated open-platform and the duration of freezing behavior of mouse was measured for 10 min. Fluoxetine and citalopram, selective serotonin (5-HT) reuptake inhibitors, markedly decreased the duration of freezing. …
  • NAID 10024316745

関連リンク

Citalopram (/saɪˈtælɵpræm/; brand names: Celexa, Cipramil) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class. It has U.S. Food and Drug Administration (FDA) approval to treat major depression, and is ...

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