chromosomes

出典: meddic

染色体

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/11 04:31:46」(JST)

wiki en

[Wiki en表示]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/02 21:29:59」(JST)

wiki en

[Wiki en表示]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/06 05:40:03」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • Viral/plasmid captures in Crenarchaea.
  • Das S, Mitra S, Sahoo S, Chakrabarti J.Author information a Department of Medical Biochemistry and Cell Biology, Institute for Biomedicine , University of Gothenburg , Göteborg , 40530 , Sweden .AbstracttRNA genes are the integration sites of viral/plasmid genomes into their hosts chromosomes by homologous recombination catalyzed by integrases. The crossover between viral/plasmid and host genomes leaves 3'-fractional tRNA motif as tell-tale marker of integration on host-chromosome. This 3'-fractional tRNA motif on host genome is our retrenched tRNA (rtRNA). To track integration in Crenarchaea, host rtRNAs, and conserved features in viral/plasmid tRNA motifs and in integrases were identified. The viral-integrase has a conserved 24-nucleotide long motif, GTATTATGTTTACTCAATAGAGAA in the N-terminal region. Upstream of the viral tRNA motif has a conserved poly-cytosine region and a hairpin secondary structure. Corresponding to a host tRNA, we observe up to two rtRNAs on crenarchaeal chromosome. The length of the rtRNA is not random. The fraction of tRNA excised off in rtRNA is either 61.8, or 50, or 38.2, or 23.6%. Thus, the integration fragments the tRNA nonrandomly dividing it approximately in ratios 3:2, or 1:1, or 2:3, or 1:3. More than 79% of rtRNAs have lengths that are excised 38.2% off tRNA. It turns out that 38.2% excision implies that the ratio of the length of tRNA to its rtRNA is just 1.618, the golden ratio. Hence, the vast majority of rtRNAs are at or near the golden ratio. Evidence emerges of new extremophile viral entities.
  • Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2014 Apr;32(4):546-54. doi: 10.1080/07391102.2013.782826. Epub 2013 May 10.
  • tRNA genes are the integration sites of viral/plasmid genomes into their hosts chromosomes by homologous recombination catalyzed by integrases. The crossover between viral/plasmid and host genomes leaves 3'-fractional tRNA motif as tell-tale marker of integration on host-chromosome. This 3'-fraction
  • PMID 23659319
  • Telomere length as a risk factor for hereditary prostate cancer.
  • Hurwitz LM, Heaphy CM, Joshu CE, Isaacs WB, Konishi Y, De Marzo AM, Isaacs SD, Wiley KE, Platz EA, Meeker AK.Author information Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.AbstractBACKGROUND: Telomeres are repetitive nucleotide sequences that stabilize the ends of chromosomes. Critically short telomeres are thought to contribute to cancer development by increasing chromosomal instability. We hypothesized that shorter leukocyte telomere length, a surrogate for inherited prostate cell telomere length, would be associated with increased risk of prostate cancer in hereditary prostate cancer (HPC) families.
  • The Prostate.Prostate.2014 Apr;74(4):359-64. doi: 10.1002/pros.22755. Epub 2013 Nov 28.
  • BACKGROUND: Telomeres are repetitive nucleotide sequences that stabilize the ends of chromosomes. Critically short telomeres are thought to contribute to cancer development by increasing chromosomal instability. We hypothesized that shorter leukocyte telomere length, a surrogate for inherited prosta
  • PMID 24285042
  • Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells.
  • Ji W, Bian Z, Yu Y, Yuan C, Liu Y, Yu L, Li C, Zhu J, Jia X, Guan R, Zhang C, Meng X, Jin Y, Bai J, Yu J, Lee KY, Sun W, Fu S.Author information Laboratory of Medical Genetics, Harbin Medical University, Harbin, People's Republic of China.AbstractDouble minute chromosomes (DMs) are a hallmark of gene amplification. The relationship between the formation of DMs and the amplification of DM-carried genes remains to be clarified. The human colorectal cancer cell line NCI-H716 and human malignant primitive neuroectodermal tumor cell line SK-PN-DW are known to contain many DMs. To examine the amplification of DM-carried genes in tumor cells, we performed Affymetrix SNP Array 6.0 analyses and verified the regions of amplification in NCI-H716 and SK-PN-DW tumor cells. We identified the amplification regions and the DM-carried genes that were amplified and overexpressed in tumor cells. Using RNA interference, we downregulated seven DM-carried genes, (NDUFB9, MTSS1, NSMCE2, TRIB1, FAM84B, MYC and FGFR2) individually and then investigated the formation of DMs, the amplification of the DM-carried genes, DNA damage and the physiological function of these genes. We found that suppressing the expression of DM-carried genes led to a decrease in the number of DMs and reduced the amplification of the DM-carried genes through the micronuclei expulsion of DMs from the tumor cells. We further detected an increase in the number of γH2AX foci in the knockdown cells, which provides a strong link between DNA damage and the loss of DMs. In addition, the loss of DMs and the reduced amplification and expression of the DM-carried genes resulted in a decrease in cell proliferation and invasion ability.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2014 Mar 15;134(6):1279-88. doi: 10.1002/ijc.28467. Epub 2013 Sep 30.
  • Double minute chromosomes (DMs) are a hallmark of gene amplification. The relationship between the formation of DMs and the amplification of DM-carried genes remains to be clarified. The human colorectal cancer cell line NCI-H716 and human malignant primitive neuroectodermal tumor cell line SK-PN-DW
  • PMID 24027017

和文文献

  • Generation of Naïve Bovine Induced Pluripotent Stem Cells Using PiggyBac Transposition of Doxycycline-Inducible Transcription Factors.
  • Kawaguchi Takamasa,Tsukiyama Tomoyuki,Kimura Koji,Matsuyama Shuichi,Minami Naojiro,Yamada Masayasu,Imai Hiroshi
  • PLOS ONE 10(8), 2015-08-19
  • … However, only naïve-type biPSCs showed the hallmarks of naïve mouse PSCs, such as LIF-dependent proliferation, lack of FGF5 expression, and active XIST expression with two active X chromosomes. …
  • NAID 120005649350
  • Molecular Characterization of UKp83/68, a Widespread Nuclear Proteins that Bind Poly(A) and Colocalize with a Nuclear Speckleʼs Component
  • Miyakura Satoru,Hara Masayuki
  • Journal of medical and dental sciences 62(2), 43-56, 2015-06
  • … During prometaphase, whenthe nuclear envelope disintegrates, the proteinbecomes partially localized on the chromosomes;at other times, transiently dispersed over thecytoplasm with the formation of fibrous structure.The transient expression of UKp83 in HEK293Tcells had no apparent effect on cellular function,whereas the expression of an antisense sequence or C-terminal domain of UKp83 induced apoptosis.These results suggest that UKp83/68 is probablyessential for cell viability and may play importantrole in mRNA processing. …
  • NAID 110009917266
  • Identification of Sex Chromosomes by Means of Comparative Genomic Hybridization in a Lizard, Eremias multiocellata
  • Wang Cui,Tang Xiaolong,Xin Ying [他]
  • Zoological science 32(2), 151-156, 2015-04
  • NAID 40020424342

関連リンク

(krō'mə-sōm') A structure in all living cells that consists of a single molecule of DNA bonded to various proteins and that carries the genes determining heredity. In all eukaryotic cells, the chromosomes occur as threadlike strands in ...
In the nucleus of each cell, the DNA molecule is packaged into thread-like structures called chromosomes. Each chromosome is made up of DNA tightly coiled many times around proteins called histones that support its ...

関連画像


押しても画像が表示されない場合はサーバが混雑しています。2週間ほどあけて、再度押下してください。


★リンクテーブル★
先読み染色体
関連記事chromosome

染色体」

  [★]

chromosome
染色体異常

染色体分析の表記

  • ISCN(1995)(An International System for Human Cytogenetic Nomenclature (1995))

ヒトの染色体

臨床関連



chromosome」

  [★] 染色体

WordNet   license wordnet

「a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order; "humans have 22 chromosome pairs plus two sex chromosomes"」

PrepTutorEJDIC   license prepejdic

「染色体」




★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡