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a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order; "humans have 22 chromosome pairs plus two sex chromosomes"

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/21 07:39:38」(JST)

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Chromosome 11 Chart

Chromosome 11 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome. Chromosome 11 spans about 134.5 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells. It is one of the most gene- and disease-rich chromosomes in the human genome.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 11 likely contains between 1,300 and 1,700 genes.

A recent study ^[1] shows that 11.6 genes per megabase, including 1,524 protein-coding genes and 765 pseudogenes can be found on chromosome 11.

More than 40% of the 856 olfactory receptor genes in the human genome are located in 28 single- and multi-gene clusters along this chromosome.

Genes[edit]

The following are some of the genes located on chromosome 11:

ACAT1: acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)
APLNR: Apelin receptor (APJ receptor)
APOA4: apolipoprotein A-IV
ATM: ataxia telangiectasia mutated (includes complementation groups A, C and D)
BDNF:secretes BDNF, a member of the Neurotrophin family of proteins
CCL9: Chemokine (C-C motif) ligand 9
CD81
C11orf1
CPT1A: carnitine palmitoyltransferase 1A (liver)
DHCR7: 7-dehydrocholesterol reductase
HBB: hemoglobin, beta
HMBS: hydroxymethylbilane VIIA
INS: insulin gene ^[2]
MMP7: Matrix metalloproteinases (MMP family)
MEN1: Multiple endocrine neoplasia type 1
PAX6
PTS: 6-pyruvoyltetrahydropterin synthase
SAA1: serum amyloid A1
SBF2: SET binding factor 2
SMPD1: sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)
TECTA: tectorin alpha (nonsyndromic deafness)
TH: tyrosine hydroxylase
USH1C: Usher syndrome 1C (autosomal recessive, severe)
WT1: Wilms tumor protein
RAG1/RAG2: recombination activating genes

Diseases & disorders[edit]

Wikinews has related news: Large study provides new insights in autism's genetic code

The following diseases are some of those related to genes on chromosome 11:

autism (neurexin 1) ^[3]
annidraedea
acute intermittent porphyria
albinism
ataxia-telangiectasia
Beckwith-Wiedemann syndrome
Best's disease
beta-ketothiolase deficiency
beta thalassemia
bladder cancer
breast cancer
carnitine palmitoyltransferase I deficiency
Charcot-Marie-Tooth disease
Charcot-Marie-Tooth disease, type 4
Cystic Fibrosis
Depression
Denys-Drash syndrome
familial Mediterranean fever
Hereditary angioedema OMIM: 106100
Jacobsen syndrome
Jervell and Lange-Nielsen syndrome
Mantle cell lymphoma (t11;14)
Meckel syndrome
methemoglobinemia, beta-globin type
Mixed Lineage Leukemia
multiple endocrine neoplasia type 1
Hereditary Multiple Exostoses
Niemann-Pick disease
nonsyndromic deafness
nonsyndromic deafness, autosomal dominant
nonsyndromic deafness, autosomal recessive
porphyria
Potocki-Shaffer Syndrome
Romano-Ward syndrome
Sickle cell anemia^[4]
Smith-Lemli-Opitz syndrome
tetrahydrobiopterin deficiency
Usher syndrome
Usher syndrome type I
WAGR syndrome
Wilms' tumor

References[edit]

^ Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
^ INS - insulin - Genetics Home Reference
^ "Autism gene breakthrough hailed". Health. BBC NEWS. 2007-02-19. Retrieved 2010-01-02.
^ Human Genome Project Information Site Has Been Updated

Gilbert F (2000). "Disease genes and chromosomes: disease maps of the human genome". Genet Test 4 (4): 409–26. doi:10.1089/109065700750065180. PMID 11216668.

UpToDate Contents

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1. 先天性の細胞遺伝学的異常 congenital cytogenetic abnormalities
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English Journal

A Case Report: Jacobsen Syndrome Complicated by Paris-Trousseau Syndrome and Shone's Complex.

Malia LA1, Wolkoff LI, Mnayer L, Tucker JW, Parikh NS.
Journal of pediatric hematology/oncology.J Pediatr Hematol Oncol.2015 Oct;37(7):e429-32. doi: 10.1097/MPH.0000000000000372.
A preterm infant presenting with a congenital cardiac malformation and thrombocytopenia was found to have a karyotype showing a terminal deletion of the long arm of chromosome 11 of the segment 11q24.1-11qter consistent with Jacobsen syndrome. The infant was later diagnosed with Paris-Trousseau synd
PMID 26056793

Detection of an inversion in the Ty-2 region between S. lycopersicum and S. habrochaites by a combination of de novo genome assembly and BAC cloning.

Wolters AM1, Caro M1, Dong S2, Finkers R1, Gao J2, Visser RG1, Wang X2, Du Y2, Bai Y3.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik.Theor Appl Genet.2015 Oct;128(10):1987-97. doi: 10.1007/s00122-015-2561-6. Epub 2015 Jul 8.
KEY MESSAGE: A chromosomal inversion associated with the tomato Ty - 2 gene for TYLCV resistance is the cause of severe suppression of recombination in a tomato Ty - 2 introgression line. Among tomato and its wild relatives inversions are often observed, which result in suppression of recombination.
PMID 26152571

Identification and fine-mapping of a new resistance gene, Xa40, conferring resistance to bacterial blight races in rice (Oryza sativa L.).

Kim SM1,2, Suh JP3, Qin Y4, Noh TH5, Reinke RF1,2, Jena KK6.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik.Theor Appl Genet.2015 Oct;128(10):1933-43. doi: 10.1007/s00122-015-2557-2. Epub 2015 Jun 17.
KEY MESSAGE: A new bacterial blight resistance gene has been identified through fine-mapping, which confers high levels of resistance to all Korean Xanthomonas oryzae pv. oryzae ( Xoo ) races, including the new Xoo race K3a. Rice bacterial leaf blight (BB) disease caused by Xanthomonas oryzae pv. or
PMID 26081948