WordNet
- quality of being easily damaged or destroyed (同)breakability, frangibleness, frangibility
- lack of physical strength (同)delicacy
- of or relating to a chromosome; "chromosomal defect"
PrepTutorEJDIC
- 壊れやすさ,もろさ;虚弱;はかなさ
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 染色体の転座、欠失、および逆位 chromosomal translocations deletions and inversions
- 2. 急性骨髄性白血病における細胞遺伝学 cytogenetics in acute myeloid leukemia
- 3. Tools for genetics and genomics: Cytogenetics and molecular genetics
- 4. 骨髄異形成症候群における細胞遺伝学および分子遺伝学 cytogenetics and molecular genetics of myelodysplastic syndromes
- 5. 出産年齢の上昇に伴う受胎能保持の選択肢 fertility preserving options for women of advancing age
English Journal
- 'Deletion rescue' by mitotic 11q uniparental disomy in a family with recurrence of 11q deletion Jacobsen syndrome.
- Johnson J, Haag M, Beischel L, McCann C, Phillips S, Tunby M, Hansen J, Schwanke C, Reynolds J.SourceDepartment of Medical Genetics, Shodair Children's Hospital, Helena, MT, USA.
- Clinical genetics.Clin Genet.2013 Apr 15. doi: 10.1111/cge.12164. [Epub ahead of print]
- We describe a family with recurrent 11q23-qter deletion Jacobsen syndrome in two affected brothers, with unique mosaic deletion 'rescue' through development of uniparental disomy (UPD) in the mother and one of the brothers. Inheritance studies show that the deleted chromosome is of maternal origin i
- PMID 23586500
- The genetic depletion or the triptolide inhibition of TFIIH in p53 deficient cells induce a JNK-dependent cell death in Drosophila.
- Villicaña C, Cruz G, Zurita M.AbstractTFIIH participates in transcription, nucleotide excision repair and the control of the cell cycle. In this work, we demonstrate that the Dmp52 subunit of TFIIH in Drosophila physically interacts with the fly p53 homologue, Dp53. The depletion of Dmp52 in the wing disc generates chromosome fragility, increases apoptosis and produces wings with a reduced number of cells; cellular proliferation, however, is not affected. Interestingly, instead of suppressing the apoptotic phenotype, the depletion of Dp53 in Dmp52-depleted wing disc cells increases apoptosis and the number of cells that suffer from chromosome fragility. The apoptosis induced by the depletion of Dmp52 alone is partially dependent on the JNK pathway. In contrast, the enhanced apoptosis caused by the simultaneous depletion of Dp53 and Dmp52 is absolutely JNK-dependent. In this study, we also show that the anti-proliferative drug triptolide, which inhibits the ATPase activity of the XPB subunit of TFIIH, phenocopies the JNK-dependent massive apoptotic phenotype of Dp53-depleted wing disc cells; this observation suggests that the mechanism by which triptolide induces apoptosis in p53-deficient cancer cells involves the activation of the JNK death pathway.
- Journal of cell science.J Cell Sci.2013 Apr 8. [Epub ahead of print]
- TFIIH participates in transcription, nucleotide excision repair and the control of the cell cycle. In this work, we demonstrate that the Dmp52 subunit of TFIIH in Drosophila physically interacts with the fly p53 homologue, Dp53. The depletion of Dmp52 in the wing disc generates chromosome fragility,
- PMID 23549790
- Systematic analysis of genomic organization and structure of long non-coding RNAs in the human genome.
- Sun J, Zhou M, Mao ZT, Hao DP, Wang ZZ, Li CX.SourceCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
- FEBS letters.FEBS Lett.2013 Apr 2;587(7):976-82. doi: 10.1016/j.febslet.2013.02.036. Epub 2013 Feb 27.
- The genomic architecture of several functional elements in animals and plants, such as microRNAs and tRNA, has been better characterized. As yet, there is very little known about genomic organization and structure of lncRNA in animals and plants. Here, we conducted a genome-wide systematic computati
- PMID 23454638
Japanese Journal
- Chromosomal fragility in patients with Triple A syndrome
- RESHMI-SKARJA S
- Am J Med Genet 117 A, 30-36, 2003
- NAID 30001968056
- The Nationwide Survey of Fanconi Anemia in Japan: A Report on Further Questionnaires:A Report on Further Questionnaires
- 矢部 みはる,矢ヶ崎 博,迫 正廣,秋山 祐一
- 日本小児血液学会雑誌 17(6), 554-556, 2003
- … Chromosomal fragility test was performed in 23 patients and genetic analysis was examined only in 7 patients. …
- NAID 130004345811
- Chromosomal 'Puffing' and Undercondensed Segments additionnal Indicators of Chromosome Fragility
- GANDHI Puneet,SENGUPTA L. K.,SENGUPTA Susmita,NICHOOLS E. M.
- Cytologia : international journal of cytology 59(4), 393-398, 1994-12-25
- NAID 10006228768
Related Links
- 1. J Pediatr Hematol Oncol. 1996 May;18(2):166-70. Pancytopenia with chromosomal fragility: vitamin B12 deficiency. Chintagumpala MM, Dreyer ZA, Steuber CP, Cooley LD. Department of Pediatrics, Texas Children's Cancer Center ...
- Advances in human genome analyses have not yet allowed identification of specific genetic mechanisms underlying the expression of human neurobehavioural disorde ... Chromosomal fragility, structural rearrangements and mobile ...
Related Pictures
★リンクテーブル★
| リンク元 | 「染色体脆弱性」「chromosome fragility」 |
| 関連記事 | 「fragility」「chromosomal」 |
「染色体脆弱性」
「chromosome fragility」
「fragility」
- n.
- 脆弱性
- 壊れやすさ、もろさ。虚弱、はかなさ
「chromosomal」
- 染色体の、染色体性の