関: choroid plexus tumor

WordNet

a network of intersecting blood vessels or intersecting nerves or intersecting lymph vessels (同)rete
a highly vascular membrane in the eye between the retina and the sclera; a dark pigmentation minimizes the scattering of light inside the eye (同)choroid coat

PrepTutorEJDIC

(神経・血管などの)網状組織
(体内にできる)新生物;腫瘍(しゅよう)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/14 10:14:26」(JST)

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A Choroid plexus papilloma (CPP) is a rare, slow-growing, histologically benign intracranial neoplasm or tumor that is commonly located in the ventricular system of the choroid plexus.^[1] It may obstruct the cerebrospinal fluid flow, causing increased intracranial pressure.

Pathophysiology

The tumor is neuroectodermal in origin and similar in structure to a normal choroid plexus. They may be created by epithelial cells of the choroid plexus.

Frequency and age affected

Internationally tumors of the choroid plexus are rare, accounting for 0.4-0.6% of all intracranial neoplasms. It most commonly affects young children under the age of 5 with a mean patient age of 5.2 years.

Signs and symptoms

Signs of the tumor resulting from increased intracranial pressure are present in 91% of patients, with vomiting, homonymous visual field defects and headache being the most common symptoms.

Surgical treatment

Choroid plexus papillomas are benign tumors that are usually cured by surgery; malignant progression has been rarely reported.

Additional images

Micrograph of a choroid plexus papilloma. H&E stain.

References

^ McEvoy AW, Harding BN, Phipps KP, et al. (April 2000). "Management of choroid plexus tumours in children: 20 years experience at a single neurosurgical centre". Pediatr Neurosurg 32 (4): 192–9. doi:10.1159/000028933. PMID 10940770. http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=pne32192.

External links

Choroid Plexus Papilloma MRI, CT, and pathology images from MedPix

UpToDate Contents

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English Journal

Differentiation of Glioma Stem Cells and Progenitor Cells into Local Host Cell-Like Cells: A Study Based on Choroidcarcinoma Differentiation of Choroid Plexus of GFP Transgenic Nude Mouse.

Wang Z1, Fei X1, Dai X2, Chen H1, Tian H3, Wang A2, Dong J2, Huang Q1,2.
Cancer biotherapy & radiopharmaceuticals.Cancer Biother Radiopharm.2015 Jun;30(5):225-32. doi: 10.1089/cbr.2014.1722.
The idea of multiple differentiation capacity of glioma stem cells and progentior cells (GSCPs) has been accepted by most of the researchers, but the effect of local environment on the differentiation of GSCPs is unclear. GSCPs SU2 and CM-Dil-stained C6 cells (C6-Dil) were injected into the brain of
PMID 26083952

Choroid Plexus Neoplasms: Toward a Distinction between Carcinoma and Papilloma Using Arterial Spin-Labeling.

Dangouloff-Ros V1, Grevent D2, Pagès M2, Blauwblomme T2, Calmon R2, Elie C2, Puget S2, Sainte-Rose C2, Brunelle F2, Varlet P2, Boddaert N2.
AJNR. American journal of neuroradiology.AJNR Am J Neuroradiol.2015 May 28. [Epub ahead of print]
Pediatric choroid plexus papillomas and carcinomas are highly vascularized neoplasms, which are difficult to distinguish with conventional imaging. We aimed to analyze the diagnostic accuracy of PWI, by using both pseudocontinuous arterial spin-labeling and DSC-PWI. We reviewed the PWI of 13 childre
PMID 26021621

Choroid plexus carcinoma in children: the Head Start experience.

Zaky W1, Dhall G, Khatua S, Brown RJ, Ginn KF, Gardner SL, Yildiz VO, Yankelevich M, Finlay JL.
Pediatric blood & cancer.Pediatr Blood Cancer.2015 May;62(5):784-9. doi: 10.1002/pbc.25436. Epub 2015 Feb 8.
BACKGROUND: Choroid plexus carcinoma (CPC) is a rare aggressive intracranial neoplasm with a predilection for young children and a historically poor outcome. Currently, no defined optimal therapeutic strategy exists. The Head Start (HS) regimens have included irradiation-avoiding strategies in young
PMID 25662896