UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 腎不全における血管石灰化の生物学 biology of vascular calcification in renal failure
2. 軟骨肉腫 chondrosarcoma
3. ユーイング肉腫ファミリーの腫瘍の疫学、病理、および分子遺伝学 epidemiology pathology and molecular genetics of the ewing sarcoma family of tumors

English Journal

Reelin/DAB-1 Signaling in the Embryonic Limb Regulates the Chondrogenic Differentiation of Digit Mesodermal Progenitors.

Diaz-Mendoza MJ1, Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM.
Journal of cellular physiology.J Cell Physiol.2014 Oct;229(10):1397-404. doi: 10.1002/jcp.24576.
Reelin is a bioactive component of some extracellular matrices. Most studies on this signaling glycoprotein have been performed in the developing nervous system, where Reelin binds to the very-low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) of target cells. This ind
PMID 24519818

BMP2 cross-linked by transglutaminase 2 to collagen-plla scaffold promotes osteogenic differentiation in mesenchymal stem cells.

Beazley KE1, Nurminskaya M.
Biotechnology letters.Biotechnol Lett.2014 Sep;36(9):1901-7. doi: 10.1007/s10529-014-1551-0. Epub 2014 Jun 15.
Transglutaminase 2 (TG2) was used to attach biologically-active BMP2 to collagen type I-coated poly-L-lactic acid (PLLA) nanofibrous scaffolds. Irreversibly cross-linked BMP2 retained its activity and induced Smad-dependent gene expression in cells seeded on PLLA-BMP2 scaffolds. These modified scaff
PMID 24930093

Effects of alginate hydrogel cross-linking density on mechanical and biological behaviors for tissue engineering.

Jang J1, Seol YJ2, Kim HJ3, Kundu J4, Kim SW5, Cho DW6.
Journal of the mechanical behavior of biomedical materials.J Mech Behav Biomed Mater.2014 Sep;37:69-77. doi: 10.1016/j.jmbbm.2014.05.004. Epub 2014 May 14.
An effective cross-linking of alginate gel was made through reaction with calcium carbonate (CaCO3). We used human chondrocytes as a model cell to study the effects of cross-linking density. Three different pore size ranges of cross-linked alginate hydrogels were fabricated. The morphological, mecha
PMID 24880568

Chondroprotective Effects of Taurine in Primary Cultures of Human Articular Chondrocytes

, , ,
The Tohoku Journal of Experimental Medicine 235(3), 201-213, 2015
… There is an urgent need to find an effective chondrogenic protection agent alleviating or inhibiting chondrocyte dedifferentiation. … Aggrecan is a cartilage-specific proteoglycan, and SOX9 is a chondrogenic transcription factor. … Thus, taurine may be a useful pro-chondrogenic agent for autologous chondrocyte implantation in the treatment of cartilage repair. …
NAID 130004822444

Hyaluronic acid enhances the effect of the PAMPS/PDMAAm double-network hydrogel on chondrogenic differentiation of ATDC5 cells

Kitamura Nobuto,Kurokawa Takayuki,Fukui Takaaki,Gong Jian P.,Yasuda Kazunori
BMC Musculoskeletal Disorders 15, 222, 2014-07-06
… The present study investigated whether DN gel induced chondrogenic differentiation of ATDC5 cells in a maintenance medium without insulin, and whether supplementation of hyaluronic acid enhanced the chondrogenic differentiation effect of DN gel. … Conclusions: The DN gel induced chondrogenic differentiation of ATDC5 cells without insulin. …
NAID 120005468150

中田恭輔,上床裕之,大倉優之介,古川拓馬,猪村剛史,深澤賢宏,大鶴直史,弓削類
理学療法学 41(2), 90-91, 2014-04-20
【目的】本研究の目的は,ヒト間葉系幹細胞の軟骨分化において模擬微小重力環境の与える影響について検討することである。【方法】培養細胞はヒト間葉系幹細胞を用いた。通常の1G重力環境下で軟骨分化誘導を行う群(以下,1G群),模擬微小重力発生装置(3D-Clinostat)によって10^<-3>G環境下で軟骨分化誘導を行う群(以下,CL群)の2群に分けて軟骨分化誘導を行った。解析は,形態学的解 …
NAID 110009816818