cholinolytic

出典: meddic

  • adj.
  • 抗コリンの
  • n.
anticholinergicanticholinergic agentanticholinergic druganticholinergicscholinergic antagonistcholinolytic drugmuscarinic antagonist

英文文献

  • Stress-associated cardiovascular reaction masks heart rate dependence on physical load in mice.
  • Andreev-Andrievskiy AA1, Popova AS2, Borovik AS3, Dolgov ON4, Tsvirkun DV3, Custaud M5, Vinogradova OL3.
  • Physiology & behavior.Physiol Behav.2014 Jun 10;132:1-9. doi: 10.1016/j.physbeh.2014.03.033. Epub 2014 May 5.
  • When tested on the treadmill mice do not display a graded increase of heart rate (HR), but rather a sharp shift of cardiovascular indices to high levels at the onset of locomotion. We hypothesized that under test conditions cardiovascular reaction to physical load in mice is masked with stress-assoc
  • PMID 24802359
  • A new activity of N-cholinolytic drug benzohexonium.
  • Khnychenko LK1, Okunevich IV, Losev NA, Sapronov NS, Yakovleva EE.
  • Bulletin of experimental biology and medicine.Bull Exp Biol Med.2012 Aug;153(4):487-9.
  • We have found that N-cholinolytic drug benzohexonium produces a hypolipidemic effect: it reduces dyslipoproteinemia, fatty infiltration of the liver, and risk of atherosclerotic lesions.
  • PMID 22977852
  • Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice.
  • Socała K1, Nieoczym D, Wyska E, Poleszak E, Wlaź P.
  • Journal of neural transmission (Vienna, Austria : 1996).J Neural Transm.2012 Jun;119(6):645-52. doi: 10.1007/s00702-011-0756-9. Epub 2012 Jan 4.
  • The cholinergic theory of depression highlights the involvement of muscarinic acetylcholine receptors in the neurobiology of mood disorders. The present study was designed to investigate the effect of sildenafil, a phosphodiesterase type 5 inhibitor which exhibits cholinomimetic properties, alone an
  • PMID 22215207

和文文献

  • 新β2アドレナリン作働薬Procaterol hydrochloride(OPC-2009)の一般薬理作用-2-末梢作用について
  • 橋本 虎六 [他],新谷 成之,山下 修司,鄭 正聰,高井 正明,筒井 正博,河村 公太郎,大川 直士,桧山 隆司,薮内 洋一
  • 日本薬理学雑誌 75(4), 333-364, 1979
  • … PRO had no α-adrenolytic, cholinolytic and anti-histaminic effects. …
  • NAID 130000759078
  • Molecular Orbital Interpretations for Cholinergic Activities of Some Alkyltrialkylammonium Derivatives
  • 木村 郁子,森島 績,米沢 貞次郎,木村 正康
  • Chemical & pharmaceutical bulletin 22(2), 429-432, 1974-02-25
  • … The electronic structures of alkyltrialkylammonium derivatives were studied by the CNDO/2 method, and cholinomimetic and cholinolytic activities of these compounds were discussed. …
  • NAID 110003633169
  • CORRELATION BETWEEN ELECTROENCEPHALOGRAPHIC (EEG) EFFECTS AND ACETYLCHOLINE CONTENT OF BRAIN AFTER CHOLINOLYTIC HALLUCINOGENS
  • Matin M.A.
  • The Japanese Journal of Pharmacology 19(4), 515-519, 1969
  • … The cholinolytic hallucinogens (atropine and hyoscine) reduce the acetylcholine content of rat brain (1) and certain parts of rabbit brain (2). …
  • NAID 130000837187

関連リンク

cholinolytic /cho·li·no·lyt·ic/ (-lit´ik). 1. blocking the action of acetylcholine, or of cholinergic agents. 2. an agent that blocks the action of acetylcholine in cholinergic areas, i.e., organs supplied by parasympathetic nerves, and voluntary muscles.
Cholinolytic definition, capable of blocking the action of acetylcholine and related compounds. See more.

関連画像

 nutrisize levekusen cholinolytic jumpAtropine) – maintenance of cholinolytic cholinolytic action international  cholinolytic/Alzheimer syndromeRum Cay Water SportsPharmacology extra credit


★リンクテーブル★
リンク元抗コリン薬」「anticholinergic」「muscarinic antagonist」「抗コリン

抗コリン薬」

  [★]

anticholinergics, anticholinergic, anticholinergic agent, anticholinergic drug, cholinolytic, cholinolytic drug, cholinergic antagonist
抗コリン剤抗コリン作用薬コリン作用遮断薬 cholinergic blocking agent
ムスカリン性受容体拮抗薬 muscarinic antagonist


  • 副交感神経ムスカリン受容体拮抗薬であり、副交感神経作用を抑制する。

抗コリン薬の主な作用

(YN2010 抗コリン薬(神経精神))
  • 1. 散瞳作用:眼底検査や虹彩炎治療など
  • 2. 膀胱利尿筋弛緩作用:尿路結石症鎮痙
  • 3. 腺分泌抑制作用:麻酔前投与
  • 4. 胃酸分泌抑制作用:抗胃潰瘍
  • 5. 消化管運動抑制作用
  • 6. 抗Parkinson作用
  • 7. 抗迷走神経作用:徐脈性不整脈の治療
  • 8. 農薬解毒作用:有機リン剤、カーバメート剤の解毒

therapeutic uses of muscarinic receptor antagonists

GOO.195
  • 呼吸器:気道分泌抑制。(アトロピンは気道分泌を抑制し、分泌物が乾固しうるが、イプラトロピウム、チオトロピウムはmucociliary clearanceにおける副作用を呈しないので、気道疾患に用いられている)
  • 泌尿器:過活動性膀胱、夜尿症、対麻痺における頻尿
  • 消化器:抗潰瘍薬(M1受容体選択性のある薬剤。ピレンゼピンテレンゼピン)。鎮痙薬



anticholinergic」

  [★]

  • adj.
  • 抗コリンの、抗コリン作用の、抗コリン性の
  • n.
anticholinergic agentanticholinergic druganticholinergicscholinergic antagonistcholinolyticcholinolytic drugmuscarinic antagonist

WordNet   license wordnet

「a substance that opposes or blocks the action of acetylcholine」
anticholinergic drug

WordNet   license wordnet

「inhibiting or blocking the action of acetylcholine at a receptor site; "anticholinergic drugs"」


muscarinic antagonist」

  [★]

anticholinergicanticholinergic agentanticholinergic druganticholinergicscholinergic antagonistcholinolyticcholinolytic drugmuscarinic receptor antagonist


抗コリン」

  [★]

抗コリン作用薬抗コリン薬抗コリン性抗コリン作用




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