cholineacetylase

出典: meddic

英文文献

  • Demonstration and nature of endothelin-3-like immunoreactivity in somatostatin and choline acetyltransferase-immunoreactive nerve cells of the neostriatum of the rat.
  • Fuxe K1, Tinner B, Staines W, Hemsén A, Hersh L, Lundberg JM.Author information 1Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden.AbstractUsing a rabbit endothelin-1 (ET-1) antiserum together with a goat-anticholineacetylase antiserum or a mouse anti-somatostatin antiserum it was possible by means of double immunolabelling procedures to demonstrate ET-like immunoreactivity in striatal nerve cell bodies of the rat, which were shown to contain either cholineacetylase or somatostatin immunoreactivity. Absorption studies with ET-3, ET-1 or big ET-1 indicated that the ET-like immunoreactivity was ET-3 like. In agreement the radioimmunoassay showed that ET-3-like immunoreactivity was present in higher concentrations than ET-1-like immunoreactivity in the neostriatum and other brain areas. Characterization by reversed phase HPLC revealed, however, that a major portion of the neostriatal ET-3-like immunoreactivity was not identical to ET-3. The nature of neuronal ET in the rat may thus be more complicated than hitherto assumed.
  • Neuroscience letters.Neurosci Lett.1991 Feb 11;123(1):107-11.
  • Using a rabbit endothelin-1 (ET-1) antiserum together with a goat-anticholineacetylase antiserum or a mouse anti-somatostatin antiserum it was possible by means of double immunolabelling procedures to demonstrate ET-like immunoreactivity in striatal nerve cell bodies of the rat, which were shown to
  • PMID 1676496
  • Structural correlations of choline acetyltransferase inhibitors: trans-N-(carboxymethyl)-4-(beta-1-naphthylvinyl)pyridinium bromide and cis-N-(2-aminoethyl)-4-(beta-1-naphthylvinyl)-3-methylpyridinium bromide hydrobromide.
  • Chweh AY, DeBernardis JF, Siuda JF, Rondan NG, Abola JE, Abraham DJ.AbstractThis paper correlates the X-ray structures of two 4-(beta-1-naphthylvinyl)pyridine analogues (one cis and one trans) with chemical and biological activity data for this class of cholineacetylase inhibitors. Our results suggest that one of the two proposed mechanisms for inhibition by this class of compounds better describes their efficacy. Previous arguments about coplanarity of the aromatic rings and nucleophilicty across the vinyl linkage need to be modified. Quantum calculations are also included and substantiate previous suggestions about the charge distribution across the vinyl linkages. An alternate new mechanism of inhibition is proposed to encompass the published data and more recent results discussed in this paper.
  • Journal of medicinal chemistry.J Med Chem.1984 Jul;27(7):825-30.
  • This paper correlates the X-ray structures of two 4-(beta-1-naphthylvinyl)pyridine analogues (one cis and one trans) with chemical and biological activity data for this class of cholineacetylase inhibitors. Our results suggest that one of the two proposed mechanisms for inhibition by this class of c
  • PMID 6737426

和文文献

  • STUDIES ON THE ULTRASTRUCTURAL DISTRIBUTION OF H<SUP>3</SUP>-DIMETACRINE IN RAT CEREBRAL CORTEX
  • 24.重症筋無力症患者血清中のアセチールコリン生成阻害因子について

関連リンク

Publication » Cholinesterases and cholineacetylase in the nervous system of the rat.. Article Cholinesterases and cholineacetylase in the nervous system of the rat. C E Heading British Journal of Pharmacology (Impact Factor: 4 ...
BIOCHEMISTRY OF THE AVIAN CENTRAL NERVOUS SYSTEM?I.: THE 5HYDROXYTRYPTOPHAN DECARBOXYLASE-MONOAMINE OXIDASE AND CHOLINEACETYLASE-ACETYCHOLINESTERASE SYSTEMS IN ... Data ...

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acetylcholine



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