WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
a gastrointestinal hormone that stimulates the secretion of pancreatic enzymes and the contraction and emptying of the gall bladder; its release is stimulated by the presence of fatty acids and amino acids in the small intestine

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=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/21 14:37:05」(JST)

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Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin.^[1] There are two different subtypes CCK_A and CCK_B which are ~50% homologous:^[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.

protein	gene	tissue distribution	preferred ligand	function
CCK_A (CCK₁)	CCKAR	primarily gastrointestinal tract, lesser amounts in the CNS	sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK	stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility
CCK_B (CCK₂)	CCKBR	primarily CNS, lesser amounts in the gastrointestinal tract	gastrin ≈ CCK (receptor does not descriminate between sulfated and nonsulfated peptides)	regulation of nociception, anxiety, memory and hunger

References [edit]

^ Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP (December 1999). "International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors". Pharmacological Reviews 51 (4): 745–81. PMID 10581329.
^ Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805–47. doi:10.1152/physrev.00014.2005. PMID 16816139.

External links [edit]

Cholecystokinin Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

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UpToDate Contents

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1. コレシストキニンの生理学 physiology of cholecystokinin
2. ガストリンの生理学 physiology of gastrin
3. 膵外分泌機能検査 pancreatic exocrine function tests
4. 胃酸分泌の生理学 physiology of gastric acid secretion
5. 肥満の薬物療法 drug therapy of obesity

English Journal

Behavioral and cortical EEG evaluations confirm the roles of both CCK(A) and CCK(B) receptors in mouse CCK-induced anxiety.

Li H, Ohta H, Izumi H, Matsuda Y, Seki M, Toda T, Akiyama M, Matsushima Y, Goto Y, Kaga M, Inagaki M.SourceDepartment of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 187-8553, Japan.
Behavioural brain research.Behav Brain Res.2013 Jan 15;237:325-32. doi: 10.1016/j.bbr.2012.09.051. Epub 2012 Oct 5.
This study investigated the roles of cholecystokinin (CCK)(A) and CCK(B) receptors on CCK-4-induced anxiety-like behaviors in mice through behavioral and neural evaluations. Anxiety-like behaviors in mice were induced by an intracerebroventricular (i.c.v.) administration of CCK-4, which can bind to
PMID 23043971

Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y.

Bowers ME, Choi DC, Ressler KJ.SourceCenter for Behavioral Neuroscience, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States.
Physiology & behavior.Physiol Behav.2012 Dec 5;107(5):699-710. doi: 10.1016/j.physbeh.2012.03.004. Epub 2012 Mar 10.
The neural circuitry of fear likely underlies anxiety and fear-related disorders such as specific and social phobia, panic disorder, and posttraumatic stress disorder. The primary pharmacological treatments currently utilized for these disorders include benzodiazepines, which act on the GABAergic re
PMID 22429904

Japanese Journal

Obesity-Related Mechanism of Food Intake Suppression

He Junfeng,Wong Siew Sun,Qu Yating,Xie Menzhou
Journal of brain science 36, 61-80, 2011-03-30
… Food intake suppression via the peripheral nervous system mainly focuses on cholecystokinin and enterostatin relaying to the central nervous system (CNS). …
NAID 110008574016

Pharmacological Evaluation of Analgesic Effects of the Cholecystokinin2 Receptor Antagonist Z-360 in Mouse Models of Formalin- and Cancer-Induced Pain

Yoshinaga Koji,Horii Takayuki,Hamano Hiroki,Eta Runa,Ozaki Tomoko,Orikawa Yuki,Yoshii Kazuyoshi,Kawabata Yoshihiro,Hori Yuko,Seto Koichi,Takei Mineo,Kuraishi Yasushi
Biological & Pharmaceutical Bulletin 33(2), 244-248, 2010
… Z-360, a novel cholecystokinin2 (CCK2) receptor antagonist, has been developed as a therapeutic drug for pancreatic cancer and showed pain relief action in phase Ib/IIa clinical trial. … YF476, another CCK2 receptor antagonist, was without effects at 1 and 10 mg/kg. … In contrast, the CCK1 receptor antagonist devazepide inhibited the nociceptive responses to formalin. …
NAID 130000156631