English Journal

Effects of the rate and composition of fluid replacement on the pharmacokinetics and pharmacodynamics of intravenous torasemide.

Kim YC1, Lee MG, Ko SH, Kim SH.
The Journal of pharmacy and pharmacology.J Pharm Pharmacol.2003 Nov;55(11):1515-22.
The effects of differences in the rate and composition of intravenous fluid replacement for urine loss on the pharmacokinetics and pharmacodynamics of torasemide were evaluated in rabbits. Each rabbit received 2-h constant intravenous infusion of 1 mg kg(-1) torasemide with 0% replacement (treatment
PMID 14713362

Changes of renal function and blood pressure after nitric oxide synthase inhibition in renal-denervated conscious rats.

Girchev R1, Mikhov D, Markova P, Vuchidolova V.
Acta physiologica et pharmacologica Bulgarica.Acta Physiol Pharmacol Bulg.2000;25(3-4):109-14.
Conscious male Wistar rats with implanted catheters in femoral artery for blood pressure registration, femoral vein for drug infusion and bladder for urine collection were used. Nitric oxide synthase inhibition (NOSI) was performed by intravenous administration of 10 mg/kg b.w. N(omega)-nitro-L-argi
PMID 11688548

Mild metabolic alkalosis impairs the natriuretic response to bumetanide in normal human subjects.

Loon NR1, Wilcox CS.
Clinical science (London, England : 1979).Clin Sci (Lond).1998 Mar;94(3):287-92.
1. This study was designed to test the hypothesis that acid-base status affects the response to a loop diuretic in human subjects. The renal responses to bumetanide (1 mg intravenously) were studied in eight normal subjects consuming a constant diet supplemented for 3 days on three separate occasion
PMID 9616263

リンク元	「塩類尿排泄亢進」「塩類尿排泄亢進性」

「塩類尿排泄亢進」