English Journal
- Haloperidol Selectively Remodels Striatal Indirect Pathway Circuits.
- Sebel LE1, Graves SM1, Chan CS1, Surmeier DJ1.
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.Neuropsychopharmacology.2016 Oct 12. doi: 10.1038/npp.2016.173. [Epub ahead of print]
- Typical antipsychotic drugs are widely thought to alleviate the positive symptoms of schizophrenia by antagonizing dopamine D2 receptors expressed by striatal spiny projection neurons (SPNs). What is less clear is why antipsychotics have a therapeutic latency of weeks. Using a combination of physiol
- PMID 27577602
- Phenothiazines solution complexity - Determination of pKa and solubility-pH profiles exhibiting sub-micellar aggregation at 25 and 37°C.
- Pobudkowska A1, Ràfols C2, Subirats X2, Bosch E2, Avdeef A3.
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2016 Oct 10;93:163-76. doi: 10.1016/j.ejps.2016.07.013. Epub 2016 Jul 21.
- The ionization constants (pKa) and the pH-dependent solubility (log S-pH) of six phenothiazine derivatives (promazine hydrochloride, chlorpromazine hydrochloride, triflupromazine hydrochloride, fluphenazine dihydrochloride, perphenazine free base, and trifluoperazine dihydrochloride) were determined
- PMID 27449396
- Development of an enzyme linked immunosorbent assay for the determination of phenothiazine drugs in meat and animal feeds.
- Shi FS1, Liu J1, Zhang L1, Liu JX1, Wang JP1.
- Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.J Environ Sci Health B.2016 Oct 2;51(10):715-721. Epub 2016 Jun 29.
- In this study, 2-chlorophenothiazine was used to synthesize a hapten for production of monoclonal antibody. The obtained monoclonal antibody showed high crossreactivities to chlorpromazine, promethazine and perphenazine, and showed low crossreactivities to acepromazine and fluphenazine. After evalua
- PMID 27356032
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