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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/09/04 16:34:14」(JST)
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Chlorotrianisene
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Systematic (IUPAC) name |
1,1',1''-(2-chloroethene-1,1,2-triyl)tris(4-methoxybenzene) |
Clinical data |
Trade names |
Tace |
AHFS/Drugs.com |
Multum Consumer Information |
Pregnancy cat. |
X (US) |
Legal status |
Discontinued |
Routes |
Oral |
Pharmacokinetic data |
Protein binding |
50 to 80% |
Identifiers |
CAS number |
569-57-3 Y |
ATC code |
G03CA06 |
PubChem |
CID 11289 |
DrugBank |
DB00269 |
ChemSpider |
10815 Y |
UNII |
6V5034L121 Y |
KEGG |
D00269 Y |
ChEBI |
CHEBI:3641 Y |
ChEMBL |
CHEMBL1200761 N |
Chemical data |
Formula |
C23H21ClO3 |
Mol. mass |
380.864 g/mol |
SMILES
- Cl/C(c1ccc(OC)cc1)=C(/c2ccc(OC)cc2)c3ccc(OC)cc3
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InChI
-
InChI=1S/C23H21ClO3/c1-25-19-10-4-16(5-11-19)22(17-6-12-20(26-2)13-7-17)23(24)18-8-14-21(27-3)15-9-18/h4-15H,1-3H3 Y
Key:BFPSDSIWYFKGBC-UHFFFAOYSA-N Y
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N (what is this?) (verify)
|
Chlorotrianisene (trade name Tace) is a non-steroidal synthetic estrogen that was formerly used for the treatment of menopause, deficiencies in ovary function, and prostate cancer.[1][2]
References
- ^ Drugs.com: Chlorotrianisene
- ^ Yuen, B. H.; Pendleton, H. J.; Blair, S. (1977). "Efficacy of bromocriptine and chlorotrianisene in preventing postpartum lactation". Canadian Medical Association journal 117 (8): 919–921. PMC 1880136. PMID 334356. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1880136/. edit
Estrogenics
|
|
Receptor |
ER (α, β)
|
|
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GPER
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- Agonists: Estradiol
- Fulvestrant
- G-1
- Genistein
- Quercetin
- Tamoxifen
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|
|
Enzyme
(inhibitors) |
20,22-Desmolase
|
- 22-ABC
- 3,3′-Dimethoxybenzidine
- 3-Methoxybenzidine
- Aminoglutethimide
- Cyanoketone
- Danazol
- Etomidate
- Mitotane
- Trilostane
|
|
17α-Hydroxylase,
17,20-Lyase
|
- 22-ABC
- 22-Oxime
- Abiraterone
- Bifonazole
- Clotrimazole
- Cyanoketone
- Cyproterone
- Danazol
- Econazole
- Galeterone
- Gestrinone
- Isoconazole
- Ketoconazole
- L-39
- Liarozole
- LY-207,320
- MDL-27,302
- Miconazole
- Mifepristone
- Orteronel
- Pioglitazone
- Rosiglitazone
- Spironolactone
- Stanozolol
- SU-10,603
- TGF-β
- Tioconazole
- Troglitazone
- VN/87-1
- YM116
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|
3β-HSD
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- 4-MA
- Azastene
- Cyanoketone
- Danazol
- Epostane
- Genistein
- Gestrinone
- Metyrapone
- Oxymetholone
- Pioglitazone
- Rosiglitazone
- Trilostane
- Troglitazone
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|
17β-HSD
|
|
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Aromatase
|
- 1,4,6-Androstatriene-3,17-dione
- 4-Androstene-3,6,17-trione
- 4-Cyclohexylaniline
- 4-Hydroxytestosterone
- 5α-DHNET
- Abyssinone II
- Aminoglutethimide
- Anastrozole
- Ascorbic acid (Vitamin C)
- Atamestane
- Bifonazole
- CGP-45,688
- CGS-47,645
- Clotrimazole
- DHT
- Difeconazole
- Econazole
- Exemestane
- Fadrozole
- Fenarimol
- Finrozole
- Formestane
- Imazalil
- Isoconazole
- Ketoconazole
- Letrozole
- Liarozole
- MEN-11066
- Miconazole
- Minamestane
- Nimorazole
- NKS01
- ORG-33,201
- Penconazole
- Plomestane
- Prochloraz
- Propioconazole
- Pyridoglutethimide
- Rogletimide
- Rotenone
- Talarozole
- Testolactone
- Tioconazole
- Triadimefon
- Triadimenol
- Troglitazone
- Vorozole
- YM511
- Zinc
Note: 5α-reductase and 21-hydroxylase inhibitors may also affect estrogen levels as they prevent metabolism of estrogen steroid precursors.
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|
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Other |
Endogenous
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- Estrogens: 5α-Androstane-3β,17β-diol
- DHEA
- Estetrol
- Estradiol
- Estriol
- Estrone
- Antiestrogens: 2-Hydroxyestrone
- 16-Hydroxyestrone
- Precursors: Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- 17-Hydroxypregnenolone
- Progesterone
- 17-Hydroxyprogesterone
- Cortodoxone/Deoxycortisol
- DHEA
- DHEA sulfate
- 16-Hydroxy-DHEA
- 16-Hydroxy-DHEA sulfate
- Androstenediol
- Androstenedione
- 16-Hydroxyandrostenedione
- Testosterone
|
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Indirect
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- Androgens/Antiandrogens (see here)
- Calcitriol (a form of Vitamin D)
- GnRH agonists/antagonists (see here)
- Gonadotropins//Antigonadotropins (see here)
- Plasma proteins (SHBG, ABP, Albumin)
- Progestogens/Antiprogestins (see here)
- Prolactin
|
|
Procedures
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- Adrenalectomy
- Hypophysectomy
- Oophorectomy
- Orchiectomy
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|
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English Journal
- Large-scale prediction and testing of drug activity on side-effect targets.
- Lounkine E, Keiser MJ, Whitebread S, Mikhailov D, Hamon J, Jenkins JL, Lavan P, Weber E, Doak AK, Côté S, Shoichet BK, Urban L.SourceNovartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA.
- Nature.Nature.2012 Jun 10;486(7403):361-7. doi: 10.1038/nature11159.
- Discovering the unintended 'off-targets' that predict adverse drug reactions is daunting by empirical methods alone. Drugs can act on several protein targets, some of which can be unrelated by conventional molecular metrics, and hundreds of proteins have been implicated in side effects. Here we use
- PMID 22722194
- Treatments for suppression of lactation.
- Oladapo OT, Fawole B.SourceMaternal and Fetal Health Research Unit, Department of Obstetrics and Gynaecology, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria. tixon_y2k@hotmail.com
- Cochrane database of systematic reviews (Online).Cochrane Database Syst Rev.2009 Jan 21;(1):CD005937.
- BACKGROUND: Various pharmacologic and nonpharmacologic interventions have been used to suppress lactation after childbirth and relieve associated symptoms. Despite the large volume of literature on the subject, there is currently no universal guideline on the most appropriate approach for suppressin
- PMID 19160258
Japanese Journal
- 各種エストロゲン投与による脳下垂体前葉細胞の細胞の組織化学的研究
- 木村 肇
- 日本内分泌学会雑誌 36(10), 1677-1694_4, 1961
- … in the cases of overdosed administration of estrogens as the functions of anterior pituitary were under the influences of estrogen.<BR>The purpose of this article is, therefore, to study histochemical changes of the anterior lobe of the pituitary gland after administration of various kinds of estrogens.<BR>Female, matured and non-parous rats and spayed rats were used as test-animals, and Estradiol benzoate, Estrone, Estrior, Ethinylestradiol, Hexron, Methallenestril and Chlorotrianisene of various con-centration were administered to the …
- NAID 130001925636
Related Links
- Drug Interaction Fosphenytoin The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, chlorotrianisene. Griseofulvin The enzyme inducer, griseofulvin, decreases the effect of the hormone agent, chlorotrianisene.
- Chlorotrianisene information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Chlorotrianisene Description of Chlorotrianisene Chlorotrianisene: A powerful ...
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