chlorodeoxyadenosine

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Cytotoxicity of chemotherapeutic agents in glyceraldehyde-3-phosphate dehydrogenase-depleted human lung carcinoma A549 cells with the accelerated senescence phenotype.

Phadke M, Krynetskaia N, Krynetskiy E.SourceDepartment of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, Pennsylvania, USA.
Anti-cancer drugs.Anticancer Drugs.2013 Apr;24(4):366-74. doi: 10.1097/CAD.0b013e32835e3378.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays a central role in glycolysis. Because cancer cells rely on aerobic glycolysis rather than oxidative phosphorylation, GAPDH-depleting agents have a therapeutic potential to impede cancer cell proliferation. Knockdown of GAPDH by RNA interference
PMID 23377192

Ghanem H, Kantarjian H, Ohanian M, Jabbour E.SourceDepartment of Leukemia , The University of Texas M. D. Anderson Cancer Center, Houston, TX , USA.
Leukemia & lymphoma.Leuk Lymphoma.2013 Apr;54(4):688-98. doi: 10.3109/10428194.2012.726722. Epub 2012 Sep 28.
Abstract Clofarabine is a second-generation purine nucleoside analog that has been synthesized to overcome the limitations and incorporate the best qualities of fludarabine and cladribine. Clofarabine acts by inhibiting ribonucleotide reductase and DNA polymerase, thereby depleting the amount of int
PMID 22957815

Mechanisms of action of the anti-VEGF monoclonal antibody bevacizumab on chronic lymphocytic leukemia cells.

Bogusz J, Majchrzak A, Mędra A, Cebula-Obrzut B, Robak T, Smolewski P.SourceDepartment of Experimental Hematology, Department of Hematology, Medical University of Lodz, Poland.
Postȩpy higieny i medycyny doświadczalnej (Online).Postepy Hig Med Dosw (Online).2013 Mar 1;67(0):107-18.
Introduction: Chronic lymphocytic leukemia (CLL) remains incurable; therefore searching for new therapeutic strategies in this disease is necessary. An important mechanism of tumor development is neoangiogenesis. A potent antiangiogenic factor, bevacizumab (Avastin, AVA), has been poorly explored in
PMID 23475487

Spontaneous remission of 2-chlorodeoxyadenosine (2-CdA)-related secondary myelodysplastic syndrome in a patient with refractory Langerhans cell histiocytosis

Outcome of pediatric patients with Langerhans cell histiocytosis treated with 2 chlorodeoxyadenosine : a nationwide survey in Japan