chlormezanone

Chlormezanone
Systematic (IUPAC) name
	2-(4-chlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
Legal status	℞ (Prescription only);
Pharmacokinetic data
Biological half-life	40.5 hours
Identifiers
CAS Number	80-77-3
ATC code	M03BB02 (WHO)
PubChem	CID 2717
IUPHAR/BPS	7323
DrugBank	DB01178
ChemSpider	2616
UNII	GP568V9G19
KEGG	D00268
ChEBI	CHEBI:3619
ChEMBL	CHEMBL1200714
Chemical data
Formula	C11H12ClNO3S
Molar mass	273.737 g/mol
	SMILES O=S1(CCC(N(C)C1C2=CC=C(C=C2)Cl)=O)=O ;
	InChI InChI=1S/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3 ; Key:WEQAYVWKMWHEJO-UHFFFAOYSA-N ;
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/23 20:24:08」(JST)

Chlormezanone (marketed under the brandname Trancopal or Fenaprim) is a drug used as an anxiolytic and a muscle relaxant.

Its use was discontinued in many countries from 1996 on, due to rare but serious cases of toxic epidermal necrolysis.

Sterling Drug Inc., US 3082209 (1958).
Surrey, A. R.; Webb, W. G.; Gesler, R. M. (1958). "Central Nervous System Depressants. The Preparation of Some 2-Aryl-4-metathiazanones". Journal of the American Chemical Society 80 (13): 3469. doi:10.1021/ja01546a065.

Wollina U, Hipler U, Seeling A, Oelschlager H (2005). "Investigations of interactions of chlormezanone racemate and its enantiomers on human keratinocytes and human leucoytes in vitro". Skin Pharmacol Physiol 18 (3): 132–138. doi:10.1159/000084910. PMID 15897685.
Seeling A, Oelschläger H, Rothley D (2000). "Important pharmaceutical-chemical characteristics of the central muscle relaxant chlormezanone". Pharmazie 55 (4): 293–6. PMID 10798243.
Oelschläger H, Klinger W, Rothley D, Seeling A, Bockhard H, Hofmann B, Machts H, Riederer H, Rackur H (1998). "[Cleavage and biotransformation of the central muscle relaxant chlormezanone]". Pharmazie 53 (9): 620–4. PMID 9770210.
Gautier V, Vincon G, Demotes-Mainard F, Albin H (1990). "[Pharmacokinetics of chlormezanone in healthy volunteers] (original in French)". Pharmazie 45 (4): 315–9. PMID 2399514.

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.

Erythema multiforme secondary to dimenhydrinate in a patient with previous similar reactions to pamabrom.

Tan DS1, Sklar GE.
The Annals of pharmacotherapy.Ann Pharmacother.2014 Mar;48(3):425-8. doi: 10.1177/1060028013518728. Epub 2014 Jan 6.
OBJECTIVE: To report a case of erythema multiforme secondary to dimenhydrinate and pamabrom cross-sensitivity.CASE SUMMARY: A 22-year-old Chinese female presented with a complaint of lip mucosal ulceration with necrosis and stomatitis, worsening over the past 24 hours and associated with reduced ora
PMID 24396093

Chen ZR, Chen LM, Du SM.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi.2012 May;30(5):391-2.
PMID 22804998

Devulder J1.
CNS drugs.CNS Drugs.2010 Oct;24(10):867-81. doi: 10.2165/11536230-000000000-00000.
Flupirtine is a centrally acting, non-opioid analgesic that is available in a number of European countries for the treatment of a variety of pain states. The therapeutic benefits seen with flupirtine relate to its unique pharmacological properties. Flupirtine displays indirect NDMA receptor antagoni
PMID 20839897