関: chimeric mouse

WordNet

the syllable naming the third (mediant) note of any major scale in solmization
being or relating to or like a chimera; "his Utopia is not as chimeric commonwealth but a practical improvement on what already exists"- Douglas Bush (同)chimerical, chimeral

PrepTutorEJDIC

ミ(全音階の第3音)
mouseの複数形
鐘を鳴らす人

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1. 遺伝学およびゲノミクスのためのツール：研究用に育種された遺伝子改変マウス tools for genetics and genomics specially bred and genetically engineered mice
2. 筋萎縮性側索硬化症の疫学および病因 epidemiology and pathogenesis of amyotrophic lateral sclerosis
3. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia
4. 赤血球産生調節 regulation of erythropoiesis
5. 急性骨髄性白血病における細胞遺伝学 cytogenetics in acute myeloid leukemia

English Journal

Significant involvement of nuclear factor-κB-inducing kinase in proper differentiation of αβ and γδ T cells.

Eshima K, Okabe M, Kajiura S, Noma H, Shinohara N, Iwabuchi K.Author information Department of Immunology, Kitasato University School of Medicine, Kanagawa, Japan.AbstractNuclear factor-κB-inducing kinase (NIK) is known to play a critical role in maintaining proper immune function. This is exemplified in the spontaneous mutant mouse lacking functional NIK, alymphoplasia (aly), which is simultaneously immune-compromised and autoimmune-prone. To investigate the role of NIK in αβ T-cell repertoire formation, we analysed T-cell development in aly/aly mice bearing a transgenic T-cell receptor (TCR). Although there were no apparent abnormalities in the mature αβ T cells of non-transgenic aly/aly mice, the maturation efficiency of idiotype(high+) T cells in the TCR-transgenic mice was lower in aly/aly mice compared with those found in aly/+ mice, suggesting that the mature αβ T-cell repertoire could be altered by the absence of functional NIK. In one strain of TCR-transgenic aly/aly mice with a negatively selecting H-2 background, the proportion of CD8(low+) idiotype(high+) cells, which are thought to potentially represent the γδ lineage of T cells, was markedly decreased. When the γδ T cells in non-transgenic aly/aly mice were investigated, the proportion of γδ T cells in the peripheral organs of aly/aly mice was found to be one-half to one-fifth of those in aly/+ mice. Analyses of bone marrow chimera mice indicated that NIK in host cells, rather than in donor cells was important for generating a normal number of peripheral γδ T cells. Collectively, these results suggest that NIK could be involved in thymic positive selection of some αβ T cells and that NIK in non-haematopoietic cells is important for the optimal development and/or maintenance of γδ T cells.
Immunology.Immunology.2014 Feb;141(2):222-32. doi: 10.1111/imm.12186.
Nuclear factor-κB-inducing kinase (NIK) is known to play a critical role in maintaining proper immune function. This is exemplified in the spontaneous mutant mouse lacking functional NIK, alymphoplasia (aly), which is simultaneously immune-compromised and autoimmune-prone. To investigate the role o
PMID 24117043

A PLGA-encapsulated chimeric protein protects against adherence and toxicity of enterotoxigenic Escherichia coli.

Nazarian S1, Gargari SL2, Rasooli I1, Hasannia S3, Pirooznia N4.Author information 1Department of Biology, Shahed University, Tehran, Iran.2Department of Biology, Shahed University, Tehran, Iran. Electronic address: slmousavi@shahed.ac.ir.3Tarbiat Modares University, Faculty of Biological Sciences, Tehran, Iran.4Faculty of Science, Department of Biology, University of Guilan, Rasht, Iran.AbstractEnterotoxigenic Escherichia coli (ETEC) are the most common cause of diarrhea among children. Colonization factors and enterotoxins are the major ETEC candidate vaccines. Since protection against ETEC mostly occurs by induction of IgA antibodies, much effort is focused on the development of oral vaccines. In this study oral immunogenicity of a poly(lactic-co-glycolic acid) (PLGA) encapsulated chimeric protein containing CfaB, CstH, CotA and LTB (Heat-labile B subunit) was investigated. The protein was encapsulated in PLGA by double emulsion method and nanoparticles were characterized physicochemically. Immunogenicity was assessed by evaluating IgG1, IgG2 and IgA titers after BALB/c mice vaccination. Non aggregated nanoparticles had a spherical shape with an average particle size of 252.7±23nm and 91.96±4.4% of encapsulation efficiency. Western blotting showed maintenance of the molecular weight and antigenicity of the released protein. Oral immunization of mice induced serum IgG and fecal IgA antibody responses. Immunization induced protection against ETEC binding to Caco-2 cells. The effect of LT toxin on fluid accumulation in ileal loops was neutralized by inhibition of enterotoxin binding to GM1-ganglosides. Delivery of the chimeric protein in PLGA elicited both systemic and mucosal immune responses. The findings could be exploited to development of oral multi-component ETEC prophylactic measures.
Microbiological research.Microbiol Res.2014 Feb-Mar;169(2-3):205-12. doi: 10.1016/j.micres.2013.06.005. Epub 2013 Jul 30.
Enterotoxigenic Escherichia coli (ETEC) are the most common cause of diarrhea among children. Colonization factors and enterotoxins are the major ETEC candidate vaccines. Since protection against ETEC mostly occurs by induction of IgA antibodies, much effort is focused on the development of oral vac
PMID 23906742

Immunogenicity of oral vaccination with Lactococcus lactis derived vaccine candidate antigen (UreB) of Helicobacter pylori fused with the human interleukin 2 as adjuvant.

Zhang HX, Qiu YY, Zhao YH, Liu XT, Liu M, Yu AL.Author information Department of Pathogeny Biology, Taishan Medical University, 2 Yingsheng East Road, Taian, Shandong 271000, PR China. Electronic address: hxzhangvip@163.com.AbstractHelicobacter pylori (H. pylori) infection remains a significant global public health problem. Vaccine, especially edible vaccine, is considered to be effective in the management of H. pylori infections. By using recombinant technology, Lactococcus lactis (L. lactis) could serve as an antigen-delivering vehicle for the development of edible vaccine. The aim of this study was to produce edible UreB (urease B) vaccine derived from L. lactis against H. pylori. The UreB subunit is the most effective and common immunogen of all strains of H. pylori. The UreB was produced as a chimeric protein fused with IL-2 (human interleukin 2) as the mucosal adjuvant. Mucosal immunization of mice with recombinant L. lactis NZ9000 containing the UreB-IL-2 protein elicited more anti-UreB antibody that specifically bounded to the purified bacterial UreB protein and more cytokines such as IFN-γ, IL-4, and IL-17, and had a lower H. pylori burden and urease activity than control mice. These results suggest that the recombinant L. lactis expressing UreB-IL-2 can be potentially used as an edible vaccine for controlling H. pylori infection.
Molecular and cellular probes.Mol Cell Probes.2014 Feb;28(1):25-30. doi: 10.1016/j.mcp.2013.08.003. Epub 2013 Sep 13.
Helicobacter pylori (H. pylori) infection remains a significant global public health problem. Vaccine, especially edible vaccine, is considered to be effective in the management of H. pylori infections. By using recombinant technology, Lactococcus lactis (L. lactis) could serve as an antigen-deliver
PMID 24036137

Japanese Journal

ヒト肝細胞キメラマウスを用いた抗ウイルス薬の薬効評価と臨床応用 (特集変貌するウイルス肝炎治療 : 最新知見とさらなる課題) -- (肝炎ウイルス総論:基礎・疫学・臨床の接点)

最新医学 70(9), 1756-1762, 2015-09
NAID 40020588406

Improvement in T helper 1-related immune responses in BALB/c mice immunized with an HIV-1 gag plasmid combined with a chimeric plasmid encoding interleukin-18 and flagellin