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- 1. 軟性下疳 chancroid
- 2. 性器潰瘍患者へのアプローチ approach to the patient with genital ulcers
- 3. 外陰部病変：形態に基づく鑑別診断 vulvar lesions differential diagnosis based on morphology
- 4. 性感染症の予防 prevention of sexually transmitted infections
- 5. リンパ肉芽腫性病 lymphogranuloma venereum
- Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum.
- Basta-Juzbašić A1, Ceović R2.Author information 1University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, HR-10000 Zagreb, Croatia.2University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, HR-10000 Zagreb, Croatia. Electronic address: email@example.com.AbstractChancroid, lymphogranuloma venereum, and granuloma inguinale may be considered as tropical venereal diseases. These diseases were a major diagnostic and therapeutic challenge in past centuries. Currently, patients with these bacterial infections that are endemic to the tropics occasionally consult with dermatologists in temperate climates. Due to the increasing frequency of travel to the tropics for tourism and work, as well as the increasing number of immigrants from these areas, it is important for dermatologists practicing in temperate climates to be familiar with the dermatologic manifestations of such infections, to be prepared to diagnose these diseases, and to treat these patients. All three "tropical" infections respond well to prompt and appropriate antimicrobial treatment, although herpes progenitalis still cannot be cured, and the number of people infected keeps growing; moreover, genital herpes can be transmitted by viral shedding before and after the visual signs or symptoms. Acyclovir, valacyclovir, and famciclovir can shorten outbreaks and make them less severe or even stop them from happening. There is currently no etiologic treatment for molluscum contagiosum, and the majority of treatment options are mechanical, causing a certain degree of discomfort. The molluscum contagiosum virus, unlike the other infectious agents mentioned, does not invade the skin.
- Clinics in dermatology.Clin Dermatol.2014 Mar-Apr;32(2):290-8. doi: 10.1016/j.clindermatol.2013.08.013.
- Chancroid, lymphogranuloma venereum, and granuloma inguinale may be considered as tropical venereal diseases. These diseases were a major diagnostic and therapeutic challenge in past centuries. Currently, patients with these bacterial infections that are endemic to the tropics occasionally consult w
- PMID 24559566
- Chancroid - desperate patient makes own diagnosis.
- Barnes P1, Chauhan M.Author information 1New Croft Centre for Sexual Health, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.AbstractWe report a case of chancroid in a white heterosexual man. This patient was seen by four separate health services over a period of five weeks with excruciatingly painful penile ulcers. Despite several negative herpes simplex virus polymerase chain reaction tests and a self-diagnosis of chancroid, he was repeatedly offered multiple courses of aciclovir. This case highlights the need for awareness of alternative diagnoses in persistent cases of genital ulcer disease.
- International journal of STD & AIDS.Int J STD AIDS.2014 Feb 17. [Epub ahead of print]
- We report a case of chancroid in a white heterosexual man. This patient was seen by four separate health services over a period of five weeks with excruciatingly painful penile ulcers. Despite several negative herpes simplex virus polymerase chain reaction tests and a self-diagnosis of chancroid, he
- PMID 24535694
- Haemophilus ducreyi Hfq contributes to virulence gene regulation as cells enter stationary phase.
- Gangaiah D, Labandeira-Rey M, Zhang X, Fortney KR, Ellinger S, Zwickl B, Baker B, Liu Y, Janowicz DM, Katz BP, Brautigam CA, Munson RS Jr, Hansen EJ, Spinola SM.AbstractTo adapt to stresses encountered in stationary phase, Gram-negative bacteria utilize the alternative sigma factor RpoS. However, some species lack RpoS; thus, it is unclear how stationary-phase adaptation is regulated in these organisms. Here we defined the growth-phase-dependent transcriptomes of Haemophilus ducreyi, which lacks an RpoS homolog. Compared to mid-log-phase organisms, cells harvested from the stationary phase upregulated genes encoding several virulence determinants and a homolog of hfq. Insertional inactivation of hfq altered the expression of ~16% of the H. ducreyi genes. Importantly, there were a significant overlap and an inverse correlation in the transcript levels of genes differentially expressed in the hfq inactivation mutant relative to its parent and the genes differentially expressed in stationary phase relative to mid-log phase in the parent. Inactivation of hfq downregulated genes in the flp-tad and lspB-lspA2 operons, which encode several virulence determinants. To comply with FDA guidelines for human inoculation experiments, an unmarked hfq deletion mutant was constructed and was fully attenuated for virulence in humans. Inactivation or deletion of hfq downregulated Flp1 and impaired the ability of H. ducreyi to form microcolonies, downregulated DsrA and rendered H. ducreyi serum susceptible, and downregulated LspB and LspA2, which allow H. ducreyi to resist phagocytosis. We propose that, in the absence of an RpoS homolog, Hfq serves as a major contributor of H. ducreyi stationary-phase and virulence gene regulation. The contribution of Hfq to stationary-phase gene regulation may have broad implications for other organisms that lack an RpoS homolog.
- mBio.MBio.2014 Feb 11;5(1):e01081-13. doi: 10.1128/mBio.01081-13.
- To adapt to stresses encountered in stationary phase, Gram-negative bacteria utilize the alternative sigma factor RpoS. However, some species lack RpoS; thus, it is unclear how stationary-phase adaptation is regulated in these organisms. Here we defined the growth-phase-dependent transcriptomes of H
- PMID 24520065
- The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase
- CORTES-BRATTI X.
- J Clin Invest 103, 107-115, 1999
- NAID 30035043445
- In vitro activity of azithromycin and against organisms associate with bacterial vaginosis and chancroid
- JONES B M
- Eur J Clin Microbol Infect Dis 7, 551-553, 1988
- NAID 30002302208
- 土井 達朗,武田 明久,岡野 学,藤広 茂,波多野 紘一,加藤 直樹,坂 義人
- 泌尿器科紀要 33(5), 724-729, 1987-05-00
- … して,1979年以前では主にPCGの投与が,1980年以降ではMINOあるいはDOXYとSPCMの併用投与が最も多く行なわれ,治癒成績はそれぞれ94%,99%であった.7) NGUに対して,1979年以前にはMINOあるいはDOXYは7例(10%)に投与されたにすぎなかったが,1980年以降では152例(89%)に投与され,その成績はそれぞれ43%,97%の治癒率であったClinical observations were made on patients with urethritis, syphilis, chancroid, genital herpes and venereal warts for the last eight years at Gifu City …
- NAID 120002159558
- Chancroid is caused by a bacteria called Haemophilus ducreyi. The infection is found in many parts of the world, such as Africa and southwest Asia. Very few people are diagnosed in the United States each year with this ...
- Chancroid Definition Chancroid is a sexually transmitted disease caused by a bacterial infection that is characterized by painful sores on the genitals. Description Chancroid is an infection of the genitals that is caused by the ...
|リンク元||「Haemophilus ducreyi」「軟性下疳」「genital ulcer disease」|
- Hemophilus ducreyi
- chancroid, soft chancre, soft sore, soft ulcer
- ulcus molle
- chancroid、genital ulcer disease