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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/27 17:32:56」(JST)

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Cevimeline (Evoxac) is a parasympathomimetic and muscarinic agonist,^[1] with particular effect on M₁ and M₃ receptors. It is used in the treatment of dry mouth and especially associated with Sjögren's syndrome.

Mechanism of action

By activating the M₃ receptors of the parasympathetic nervous system, cevimeline stimulates secretion by the salivary glands, thereby alleviating dry mouth.

Side effects

Known side effects include nausea, vomiting, diarrhea, excessive sweating, rash, headache, runny nose, cough, drowsiness, hot flashes, blurred vision, and difficulty sleeping.^[2]

Contraindications include asthma and angle closure glaucoma.^{[citation needed]}

References

^ Ono M, Takamura E, Shinozaki K; et al. (July 2004). "Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study". Am. J. Ophthalmol. 138 (1): 6–17. doi:10.1016/j.ajo.2004.02.010. PMID 15234277.
^ [1] MedicineNet: Cevimeline. Accessed 10/12/2007

External links

Evoxac website

UpToDate Contents

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1. シェーグレン症候群における口内乾燥およびその他の非眼結膜炎症状の治療 treatment of dry mouth and other non ocular sicca symptoms in sjogrens syndrome
2. 頭頚部癌の後期合併症のマネージメントおよびその治療 management of late complications of head and neck cancer and its treatment
3. 癌生存者における口腔の衛生状態 oral health in cancer survivors
4. シェーグレン症候群による全身および腺外症状の治療 treatment of systemic and extraglandular manifestations of sjogrens syndrome
5. シェーグレン症候群におけるドライアイの治療 treatment of dry eye in sjogrens syndrome

English Journal

Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.

Ono K, Inagaki T, Iida T, Wakasugi-Sato N, Hosokawa R, Inenaga K.SourceDepartment of Biosciences, Kyushu Dental College, 2-6-1, Manazuru, Kokurakitaku, Kitakyushu, Fukuoka 803-8580, Japan.
Archives of oral biology.Arch Oral Biol.2011 Nov 16. [Epub ahead of print]
OBJECTIVE: Cevimeline and pilocarpine (muscarinic receptor agonists) are used as sialogogues in xerostomia treatment. It is important to know the different effects on their salivary mechanisms and the side effects. The aim of the present study was to clarify and compare the comprehensive effects of
PMID 22099058

Management of xerostomia and salivary gland hypofunction.

Ram S, Kumar S, Navazesh M.SourceUniversity of Southern California, School of Dentistry, Division of Periodontology, Diagnostic Sciences and Dental Hygiene, Los Angeles 90089-0641, USA.
Journal of the California Dental Association.J Calif Dent Assoc.2011 Sep;39(9):656-9.
Xerostomia and salivary gland hypofunction are conditions that have been associated with increased prevalence of caries, periodontitis, and candidiasis. Oral health care providers must be aware of the etiologies and clinical manifestations of salivary gland hypofunction in order to identify patients
PMID 22034800

Japanese Journal

Management of dry mouth in Sjogren's syndrome

NAKAGAWA Yoichi
The Japanese dental science review 47(2), 115-123, 2011-08-01
NAID 10029547793

二次出版シェーグレン症候群患者に対するセビメリンの効果予測の検討

山田浩之,中川洋一,山近重生 [他]
日本口腔外科学会雑誌 57(5), 242-250, 2011-05
NAID 40018862911

Related Pictures

★リンクテーブル★

リンク元	「セビメリン」「Evoxac」
拡張検索	「cevimeline hydrochloride hydrate」

「セビメリン」

Cevimeline
Systematic (IUPAC) name
	2-Methyspiro(1,3-oxathiolane-5,3)quinuclidine
Clinical data
Trade names	Evoxac
AHFS/Drugs.com	monograph
MedlinePlus	a608025
Pregnancy; category	C;
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Pharmacokinetic data
Protein binding	< 20%
Identifiers
CAS Number	107233-08-9
ATC code	N07AX03
PubChem	CID: 83898
DrugBank	DB00185
ChemSpider	75707
UNII	K9V0CDQ56E
KEGG	D07667
ChEBI	CHEBI:3568
ChEMBL	CHEMBL1201267
Chemical data
Formula	C10H17NOS
Molecular mass	199.31308 g/mol
	SMILES O1[C@H](SC[C@@]12CN3CCC2CC3)C ;
	InChI InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8-,10-/m1/s1 ; Key:WUTYZMFRCNBCHQ-PSASIEDQSA-N ;
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