上位離断脳
English Journal
- [Constant direct action of the magnetic field on the brain fabric].
- Luk'ianova SN.AbstractThe important role of direct action of a constant magnetic field (CMF) on a fabric of a brain in its realization neural-effects under condition of an irradiation of a head of an animal is shown. In experiments on rabbits it is statistically proved, that a various degree of neural isolation of a bark of a brain, not only does not interfere with display of reaction of its bioelectric activity on CMF, but also does by its more precise (unequivocal, intensive, short-latent), in comparison with corresponding answers of intact brain. The comparative analysis of bioelectric activity of intact brain, a preparation "cerveau isole", the neural-isolated strip of a bark (at rabbits) and completely isolated nervous system (a chain of a river cancer) in conditions of action CMF proves the above-stated position.
- Radiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk.Radiats Biol Radioecol.2009 Jan-Feb;49(1):107-12.
- The important role of direct action of a constant magnetic field (CMF) on a fabric of a brain in its realization neural-effects under condition of an irradiation of a head of an animal is shown. In experiments on rabbits it is statistically proved, that a various degree of neural isolation of a bark
- PMID 19368331
- Endogenous DA-mediated feedback inhibition of DA neurons: involvement of both D(1)- and D(2)-like receptors.
- Shi WX1, Pun CL, Smith PL, Bunney BS.Author information 1Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA. wei-xing.shi@yale.eduAbstractTo investigate the role of D(1)-like receptors in endogenous dopamine (DA)-mediated feedback control of DA neurons in vivo, single unit recordings were made from rat nigral DA cells using low cerveau isolé preparations. The D(2) antagonist raclopride, but not the D(1) antagonist SCH23390, increased baseline activity of DA neurons, suggesting that spontaneously released DA acts primarily through D(2)-like receptors to inhibit DA cells. However, feedback inhibition induced by an increased DA release by D-amphetamine (1 mg/kg, i.v.) was partially reversed by SCH23390. The same inhibition, on the other hand, was always completely reversed by raclopride, suggesting that the D(1)-mediated portion of the inhibition depends upon co-activation of D(2)-like receptors. In rats with forebrain hemitransections, D-amphetamine-induced inhibition was markedly decreased and the remaining inhibition was not blocked by SCH23390, supporting the suggestion that D(1)-D(2) co-activation-induced inhibition is mediated through long feedback pathways. In chloral hydrate-anesthetized rats, D-amphetamine-induced inhibition was also insensitive to SCH23390; however, the degree of the inhibition was not reduced. Combined with previous studies, these data suggest that chloral hydrate not only inactivates the D(1) feedback pathway but also enables the D(2) feedback pathway to operate independently of D(1)-like receptors. Conversely, in parkinsonian animals D(1) receptor activation alone has been reported to inhibit DA cells. Taken together, these results suggest that a major portion of endogenous DA-mediated feedback inhibition is due to concurrent activation of D(1)- and D(2)-like receptors. However, this D(1)-D(2) interdependence may alter under certain conditions and may play a role in the pathophysiology of Parkinson's disease.
- Synapse (New York, N.Y.).Synapse.2000 Feb;35(2):111-9.
- To investigate the role of D(1)-like receptors in endogenous dopamine (DA)-mediated feedback control of DA neurons in vivo, single unit recordings were made from rat nigral DA cells using low cerveau isolé preparations. The D(2) antagonist raclopride, but not the D(1) antagonist SCH23390, increased
- PMID 10611636
- D1-D2 interaction in feedback control of midbrain dopamine neurons.
- Shi WX1, Smith PL, Pun CL, Millet B, Bunney BS.Author information 1Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA.AbstractDopamine (DA) D1-like receptors are present in pathways implicated in feedback control of midbrain DA neurons. However, stimulation of these receptors either produces no effect on DA cells, or the effect is inconsistent. It is possible that the expression of a D1 feedback effect requires co-activation of D2-like receptors. To test this hypothesis, we recorded extracellularly the spontaneous activity of nigral DA cells in a low cerveau isolé rat preparation. SKF38393 and dyhydrexidine, two D1 agonists, were administered systemically to animals pretreated with different doses of the D2 agonist quinpirole. Supporting the hypothesis, the two D1 agonists consistently inhibited DA cells in animals given high doses of quinpirole (>/=40 microg/kg, i.v.). However, no significant D1 effect was observed in animals pretreated with only low doses (</=20 microg/kg) of quinpirole. Because low doses of D2 agonists preferentially act on DA autoreceptors, and because the D1 inhibition persisted in animals whose DA autoreceptors were blocked by intranigral application of raclopride, our results suggest that the expression of D1 feedback inhibition requires co-activation of D2-like receptors on DA target neurons, instead of DA neurons themselves. These results, together with the finding that chloral hydrate completely blocked the D1 inhibition, may explain why previous studies have failed to show a consistent D1 effect on DA cells and suggest that drugs designed to act specifically on one subtype of DA receptor may, via feedback pathways, influence the action of endogenous DA on other DA receptor subtypes as well.
- The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.1997 Oct 15;17(20):7988-94.
- Dopamine (DA) D1-like receptors are present in pathways implicated in feedback control of midbrain DA neurons. However, stimulation of these receptors either produces no effect on DA cells, or the effect is inconsistent. It is possible that the expression of a D1 feedback effect requires co-activati
- PMID 9315916
Japanese Journal
- ECG sleep-waking rhythms and bodily activity in the cerveau isole rat
- Pharmacological Studies on Chinese Cinnamon. III. Electroencephalographic Studies of Cinnamaldehyde in the Rabbit
- 原田 正敏,藤井 祐一,神谷 譲二
- Chemical & pharmaceutical bulletin 24(8), 1784-1788, 1976-08-25
- … In the low cerveau isole preparation, CA either converted a resting pattern in the ECoG to a sequence of low voltage fast waves or did not elicit such an action depending upon each individual preparation. … In the high cerveau isole preparation, CA was not capable of producing any effect on the ECoG. …
- NAID 110003635175
- EFFECT OF LYONIOL-A ON DECEREBRATE RIGIDITY AND ELECTROENCEPHALOGRAM IN RATS
- Fukuda Hideomi [他],WATANABE Kazuo,ITO Tsugutaka
- The Japanese Journal of Pharmacology 22(4), 457-465, 1972
- … For this reason, the effects of lyoniol-A on the cortical and subcortical EEG patterns in the encephale isole and cerveau isolé rats were examined. …
- NAID 130000837918
Related Links
- cerveau isole cerveau isolé cervelas Cervelat Cervelliere cervellière cervena Cervena Klevanjka Cervenka syndrome Cervenka, Jaroslav Cervera y Topete, Pascual Cerveteri cerveza cervic(o)-cervic-cervic-cervical cervical cervical ...
- 1. Neurosci Biobehav Rev. 1988 Spring;12(1):39-48. What the cerveau isolé preparation tells us nowadays about sleep-wake mechanisms? Gottesmann C(1). Author information: (1)Laboratoire de Psychophysiologie, Faculté ...