WordNet
- used of preliterate or tribal or nonindustrial societies; "primitive societies"
- a person who belongs to an early stage of civilization (同)primitive person
- a mathematical expression from which another expression is derived
- a word serving as the basis for inflected or derived forms; "`pick is the primitive from which `picket is derived"
- of or created by one without formal training; simple or naive in style; "primitive art such as that by Grandma Moses is often colorful and striking" (同)naive
- of or relating to the cerebrum or brain; "cerebral hemisphere"; "cerebral activity"
- involving intelligence rather than emotions or instinct; "a cerebral approach to the problem"; "cerebral drama" (同)intellectual
- an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm
PrepTutorEJDIC
- 『原始の』,太古の / 原始的な,そぼくな;古風な,旧式な / 原始人
- 大脳の,脳の / 頭脳的な,知的な
UpToDate Contents
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- 1. まれな脳腫瘍 uncommon brain tumors
- 2. ユーイング肉腫ファミリーの腫瘍の疫学、病理、および分子遺伝学 epidemiology pathology and molecular genetics of the ewing sarcoma family of tumors
- 3. ユーイング肉腫ファミリーの腫瘍に対する放射線療法 radiation therapy for ewing sarcoma family of tumors
- 4. 松果体部腫瘍 pineal gland masses
- 5. 軟部および骨肉腫の病原因子 pathogenetic factors in soft tissue and bone sarcomas
English Journal
- Tropism of the in situ growth from biopsies of childhood neuroectodermal tumors following transplantation into experimental teratoma.
- Jamil S1, Hultman I, Cedervall J, Ali RQ, Fuchs G, Gustavsson B, Asmundsson J, Sandstedt B, Kogner P, Ährlund-Richter L.Author information 1Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.AbstractExperimental teratoma induced from human pluripotent stem cells with normal karyotype can be described as a failed embryonic process and includes besides advanced organoid development also large elements of tissue with a prolonged occurrence of immature neural components. Such immature components, although benign, exhibit strong morphological resemblance with tumors of embryonic neuroectodermal origin. Here, we demonstrate that biopsy material from childhood tumors of neural embryonic origin transplanted to mature experimental teratoma can show an exclusive preference for matching tissue. Tumor specimens from five children with; Supratentorial primitive neuroectodermal tumor (sPNET); Pilocytic astrocytoma of the brainstem; Classic medulloblastoma; peripheral primitive neuroectodermal tumor (pPNET) or neuroblastoma (NB), respectively, were transplanted. Analysis of up to 120 sections of each tumor revealed an engraftment for three of the transplanted tumors: pPNET, sPNET, and NB, with a protruding growth from the latter two that were selected for detailed examination. The histology revealed a strict tropism with a non-random integration into what morphologically appeared as matched embryonic microenvironment recuperating the patient tumor histology. The findings suggest specific advantages over xenotransplantation and lead us to propose that transplantation to the human embryonic microenvironment in experimental teratoma can be a well-needed complement for preclinical in vivo studies of childhood neuroectodermal tumors.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Apr 1;134(7):1630-7. doi: 10.1002/ijc.28498. Epub 2013 Oct 17.
- Experimental teratoma induced from human pluripotent stem cells with normal karyotype can be described as a failed embryonic process and includes besides advanced organoid development also large elements of tissue with a prolonged occurrence of immature neural components. Such immature components, a
- PMID 24122295
- A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer.
- Robison NJ1, Campigotto F, Chi SN, Manley PE, Turner CD, Zimmerman MA, Chordas CA, Werger AM, Allen JC, Goldman S, Rubin JB, Isakoff MS, Pan WJ, Khatib ZA, Comito MA, Bendel AE, Pietrantonio JB, Kondrat L, Hubbs SM, Neuberg DS, Kieran MW.Author information 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Division of Pediatric Hematology-Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.AbstractBACKGROUND: Preclinical models show that an antiangiogenic regimen at low-dose daily (metronomic) dosing may be effective against chemotherapy-resistant tumors. We undertook a prospective, open-label, single-arm, multi-institutional phase II study to evaluate the efficacy of a "5-drug" oral regimen in children with recurrent or progressive cancer.
- Pediatric blood & cancer.Pediatr Blood Cancer.2014 Apr;61(4):636-42. doi: 10.1002/pbc.24794. Epub 2013 Oct 4.
- BACKGROUND: Preclinical models show that an antiangiogenic regimen at low-dose daily (metronomic) dosing may be effective against chemotherapy-resistant tumors. We undertook a prospective, open-label, single-arm, multi-institutional phase II study to evaluate the efficacy of a "5-drug" oral regimen
- PMID 24123865
- A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma.
- Kroesen M1, Nierkens S, Ansems M, Wassink M, Orentas RJ, Boon L, den Brok MH, Hoogerbrugge PM, Adema GJ.Author information 1Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Department of Pediatric Oncology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands.AbstractCurrent multimodal treatments for patients with neuroblastoma (NBL), including anti-disialoganglioside (GD2) monoclonal antibody (mAb) based immunotherapy, result in a favorable outcome in around only half of the patients with advanced disease. To improve this, novel immunocombinational strategies need to be developed and tested in autologous preclinical NBL models. A genetically well-explored autologous mouse model for NBL is the TH-MYCN model. However, the immunobiology of the TH-MYCN model remains largely unexplored. We developed a mouse model using a transplantable TH-MYCN cell line in syngeneic C57Bl/6 mice and characterized the immunobiology of this model. In this report, we show the relevance and opportunities of this model to study immunotherapy for human NBL. Similar to human NBL cells, syngeneic TH-MYCN-derived 9464D cells endogenously express the tumor antigen GD2 and low levels of MHC Class I. The presence of the adaptive immune system had little or no influence on tumor growth, showing the low immunogenicity of the NBL cells. In contrast, depletion of NK1.1+ cells resulted in enhanced tumor outgrowth in both wild-type and Rag1(-/-) mice, showing an important role for NK cells in the natural anti-NBL immune response. Analysis of the tumor infiltrating leukocytes ex vivo revealed the presence of both tumor associated myeloid cells and T regulatory cells, thus mimicking human NBL tumors. Finally, anti-GD2 mAb mediated NBL therapy resulted in ADCC in vitro and delayed tumor outgrowth in vivo. We conclude that the transplantable TH-MYCN model represents a relevant model for the development of novel immunocombinatorial approaches for NBL patients.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Mar 15;134(6):1335-45. doi: 10.1002/ijc.28463. Epub 2013 Sep 14.
- Current multimodal treatments for patients with neuroblastoma (NBL), including anti-disialoganglioside (GD2) monoclonal antibody (mAb) based immunotherapy, result in a favorable outcome in around only half of the patients with advanced disease. To improve this, novel immunocombinational strategies n
- PMID 24038106
Japanese Journal
- Atypical Teratoid / Rhabdoid Tumor（AT/RT）の最新知見
- Neuro-Oncologyの進歩 20(1), 12-16, 2014
- NAID 130004648349
- Primary Cerebral Neuroblastoma: A Case Report and Review.
- The Tohoku Journal of Experimental Medicine 197(1), 55-65, 2002
- NAID 130004459176
- 犬の原始神経外胚葉性腫瘍(PNET)の一例(短報)
- The journal of veterinary medical science 63(1), 103-105, 2001-01-25
- NAID 110003920562
Related Links
- Molecular Genetics of Supratentorial Primitive Neuroectodermal Tumors and Pineoblastoma Mei Hua Li, Ph.D.; Eric Bouffet, M.D.; Cynthia E. Hawkins, M.D., Ph.D ... Collectively, supratentorial PNETs are relatively rare, representing ...
- Most peripheral primitive neuroectodermal tumors (pPNETs) manifest in the thoracopulmonary region (Askin tumor), pelvis, abdomen, and extremities. In a large series of 26 cases, Jones and McGill reported 11 of 26 ...
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★リンクテーブル★
| リンク元 | 「spongioblastoma」「medulloepithelioma」「大脳原始神経外胚葉性腫瘍」 |
| 関連記事 | 「cerebral」「primitive」「tumor」 |
「spongioblastoma」
「medulloepithelioma」
「大脳原始神経外胚葉性腫瘍」
「cerebral」
- adj.
- 大脳の、大脳性の、脳性の、脳の
「primitive」
- adj.
- 原始的な
「tumor」
- n.