cerebral blood flow

出典: meddic

脳血流量, CBF

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/12 16:17:15」(JST)

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英文文献

  • The capillary dysfunction hypothesis of Alzheimer's disease.
  • Ostergaard L, Aamand R, Gutiérrez-Jiménez E, Ho YC, Blicher JU, Madsen SM, Nagenthiraja K, Dalby RB, Drasbek KR, Møller A, Brændgaard H, Mouridsen K, Jespersen SN, Jensen MS, West MJ.SourceCenter of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark; Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: leif@cfin.dk.
  • Neurobiology of aging.Neurobiol Aging.2013 Apr;34(4):1018-31. doi: 10.1016/j.neurobiolaging.2012.09.011. Epub 2012 Oct 18.
  • It is widely accepted that hypoperfusion and changes in capillary morphology are involved in the etiopathogenesis of Alzheimer's disease (AD). This is difficult to reconcile with the hyperperfusion observed in young high-risk subjects. Differences in the way cerebral blood flow (CBF) is coupled with
  • PMID 23084084
  • On-line blood viscosity monitoring in vivo with a central venous catheter, using electrical impedance technique.
  • Pop GA, Bisschops LL, Iliev B, Struijk PC, Hoeven JG, Hoedemaekers CW.SourceDepartment of Cardiology, Radboud University Nijmegen Medical Centre, P.O Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: G.Pop@cardio.umcn.nl.
  • Biosensors & bioelectronics.Biosens Bioelectron.2013 Mar 15;41:595-601. doi: 10.1016/j.bios.2012.09.033. Epub 2012 Oct 4.
  • Blood viscosity is an important determinant of microvascular hemodynamics and also reflects systemic inflammation. Viscosity of blood strongly depends on the shear rate and can be characterized by a two parameter power-law model. Other major determinants of blood viscosity are hematocrit, level of i
  • PMID 23089327
  • Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice.
  • Pimentel-Coelho PM, Michaud JP, Rivest S.SourceLaboratory of Endocrinology and Genomics, CHUQ (CHUL) Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, Canada.
  • Neurobiology of aging.Neurobiol Aging.2013 Mar;34(3):679-93. doi: 10.1016/j.neurobiolaging.2012.06.025. Epub 2012 Jul 20.
  • Understanding the contribution of cerebrovascular factors in the progression of cognitive decline in Alzheimer's disease (AD) is a key step for the development of preventive therapies. Among these factors, chronic cerebral hypoperfusion is an early component of AD pathogenesis that can predict the p
  • PMID 22819135

和文文献

  • EFFECT OF LIDOCAINE ON DYNAMIC CHANGES IN CORTICAL REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FLUORESCENCE DURING TRANSIENT FOCAL CEREBRAL ISCHEMIA IN RATS
  • Naito H.,Takeda Y.,Danura T.,Kass I. S.,Morita K.
  • Neuroscience 235, 59-69, 2013-04-03
  • … Rats were subjected to 90 min of focal ischemia by occluding the left middle cerebral and both common carotid arteries. … Following the initiation of ischemia, an area of high-intensity NADH fluorescence rapidly developed in the middle cerebral artery territory in both groups and the DC potential in this area showed ischemic depolarization. … The blood flow in the marginal zone of both groups showed a similar decrease. …
  • NAID 120005324794
  • O-27 Is aerobic exercise capacity related to cerebral blood flow velocity in postmenopausal women?(The Proceedings of the 20th Annual Meetings of Japan Society of Exercise and Sports Physiology July 28・29,(Tsukuba))
  • AKAZAWA Nobuhiko,CHOI Youngju,MIYAKI Asako,AJISAKA Ryuichi,MAEDA Seiji
  • Advances in exercise and sports physiology 18(4), 95, 2013-02-00
  • NAID 110009592342
  • An Impairment of Recognizing Emotional Facial Expressions in Parkinson's Disease
  • Nakajima Hideki,Tsujino Akira,Doi Hirokazu,Tateishi Yohei,Motomura Masakatsu,Shinohara Kazuyuki,Satoh Akira,Tsujihata Mitsuhiro,Kawakami Atsushi
  • Acta medica Nagasakiensia 57(3), 69-77, 2013-02-00
  • … we demonstrated that PD patients displayed a prominent degree of hypoperfusion in the occipital lobe, while also demonstrating an impairment in recognizing the facial emotions for both anger and happiness.The ability to recognize the facial emotions for happiness has been shown to be closely associated with a decreased cerebral blood flow (CBF) in the right occipital lobe.In PD patients, an impairment in recognizing emotional facial expressions might be partially due to an occipital cortical …
  • NAID 110009552089

関連リンク

Understanding the relationship between cerebral circulation and cerebral function has evolved through refinements in the delineation of cerebral anatomy and physiology. Ischemic injury may be a final common pathway in many types ...
Cerebral Blood Flow - Download as Text file (.txt), Word Doc (.doc), PDF File (.pdf) or read online. ... Cerebral blood flow

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★リンクテーブル★
リンク元脳血流」「脳血流量」「CBF

脳血流」

  [★]

cerebral blood flow
脳血流量

麻酔薬、鎮痛薬と脳血流

静脈麻酔薬#静脈麻酔薬の脳への作用 および 吸入麻酔薬#麻酔薬と脳に及ぼす影響 より。文献的な裏付けなし。

分類 投与経路 薬剤名 脳血流 脳代謝量
麻酔薬 静脈
(静脈麻酔薬)
プロポフォール ↓↓
バルビツレート
ミダゾラム
ケタミン ↑↑
吸入
(吸入麻酔薬)
亜酸化窒素
セボフルラン
イソフルラン
ハロタン ↑↑
鎮痛薬 静脈 フェンタニル
レミフェンタニル
吸入麻酔薬では脳血管拡張作用により脳血流が増加
静脈麻酔薬の興奮性麻酔薬では脳神経活動亢進、酸素消費量増大など代謝の亢進のために脳血管拡張を来たし、脳血流増加 (SAN.45)
静脈麻酔薬の抑制性麻酔薬では脳神経活動低下、酸素消費量低下など代謝の低下のために脳血管収縮を来たし、脳血流低下 (SAN.45)

SAN.291改変

分類 薬剤名 脳血流 脳酸素消費量
吸入麻酔薬 亜酸化窒素 ↑↑
ハロタン ↑↑
イソフルラン ↓↓
セボフルラン →↑ ↓↓
静脈麻酔薬 チオペンタール ↓↓ ↓↓
プロポフォール ↓↓
フェンタニル
ケタミン ↑↑



脳血流量」

  [★]

cerebral blood flow, CBF
  • 単位時間当りに脳を流れる血液の量。
  • 成人の全脳血流量は、脳重量を1500gとすると約750mL/分
  • 安静時心拍出量のほぼ15%
  • 性状では40-60 ml/100g/分。10-12 ml/100g/分では細胞が壊死に至る。15 ml/100g/分程度あっても血流障害状態が3時間以上続くと脳梗塞に陥る。(SCN.152)


CBF」

  [★]





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