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a semisynthetic analogue of cephalosporin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/04 17:35:24」(JST)

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Cefalotin (INN) /ˌsɛfəˈloʊtᵻn/ or cephalothin (USAN) /ˌsɛfəˈloʊθᵻn/ is a first-generation cephalosporin antibiotic.^[1] It was the first cephalosporin marketed (1964) and continues to be widely used.^[2] It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. Cefalotin sodium is marketed as Keflin (Lilly) and under other trade names.^[3]

References

^ Hameed, T. K.; Robinson, J. L. (2002). "Review of the use of cephalosporins in children with anaphylactic reactions from penicillins". The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses. 13 (4): 253–8. PMC 2094874 . PMID 18159398.
^ David Greenwood (21 February 2008). Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph. OUP Oxford. pp. 128–. ISBN 978-0-19-953484-5.
^ International Drug Names: Cefalotin

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1. セフェム系 cephalosporins
2. セファロスポリン-アレルギー患者：セファロスポリンおよび関連抗菌薬のその後の使用 cephalosporin allergic patients subsequent use of cephalosporins and related antibiotics
3. アミノグリコシドによる腎毒性の症状および危険因子 manifestations of and risk factors for aminoglycoside nephrotoxicity
4. 副腎アンドロゲンの測定 measurement of adrenal androgens
5. 持続的腎代替療法中の薬物除去 drug removal during continuous renal replacement therapy

English Journal

Prevalence, molecular characterization, and antibiotic susceptibility of Cronobacter spp. in Chinese ready-to-eat foods.

Xu X1, Li C1, Wu Q2, Zhang J1, Huang J1, Yang G1.
International journal of food microbiology.Int J Food Microbiol.2015 Jul 2;204:17-23. doi: 10.1016/j.ijfoodmicro.2015.03.003. Epub 2015 Mar 6.
Cronobacter spp. are foodborne pathogens that cause rare but life-threatening diseases in neonates and infants; they can also cause disease in adults. Cronobacter spp. contamination of ready-to-eat (RTE) foods has been reported previously. However, to date, the prevalence and contamination levels of
PMID 25828706

Multiple antibiotic resistance indexing of Escherichia coli to identify high-risk sources of faecal contamination of water.

Titilawo Y1, Sibanda T, Obi L, Okoh A.
Environmental science and pollution research international.Environ Sci Pollut Res Int.2015 Jul;22(14):10969-80. doi: 10.1007/s11356-014-3887-3. Epub 2015 Mar 18.
We evaluated the antibiogram profile of Escherichia coli (n = 300) isolated from selected rivers in Osun State, Nigeria. The identities of the E. coli isolates were confirmed by polymerase chain reaction (PCR) technique. Susceptibility of the isolates to 20 antibiotics conventionally used in cli
PMID 25779106

Phenotypic antimicrobial susceptibility and occurrence of selected resistance genes in gram-positive mastitis pathogens isolated from Wisconsin dairy cows.

Ruegg PL1, Oliveira L2, Jin W3, Okwumabua O4.
Journal of dairy science.J Dairy Sci.2015 Jul;98(7):4521-34. doi: 10.3168/jds.2014-9137. Epub 2015 Apr 23.
In the United States, few intramammary antimicrobials exist that are approved for treatment of bovine mastitis; thus, ensuring judicious use of these products is a priority. The objectives of this study were to determine phenotypic susceptibility and presence of selected antimicrobial resistance gen
PMID 25912858

Japanese Journal

Salmonella serovars and antimicrobial resistance in strains isolated from wild animals in captivity in Sinaloa, Mexico

Japanese Journal of Veterinary Research 62(3), 129-134, 2014-08
NAID 120005469241

In Vitro Antibiotic Susceptibility of <i>Francisella tularensis</i> Isolates from Japan

Japanese Journal of Infectious Diseases 66(6), 534-536, 2013
NAID 130003390336

h-CLATを用いた医薬品のアレルゲン性評価

日本毒性学会学術年会 39.1(0), P-209, 2012
NAID 130005008815

Related Pictures

C59450-1.0 - Cephalothin Sodium Salt, 1 Gram Cephalothin by Damien Hirst - Paragon Cephalothin (Cefalotin) : Uses, Dosage, Side Effects, Interactions RPI Cephalothin Sodium Salt, 1g Powder - 30TX77|C59450-1.0 - Grainger Cephalothin; Cefalotin; Sodium Cephalothin Cephalothin 30 µg CLSI - KAIROSafe Product Listing » Asepsis Pharmaceuticals Peptic Ulcer and Helicobacter pylori infection: - ppt video online download

★リンクテーブル★

リンク元	「セファロチン」「cefalotin sodium」「cefalotin」

「セファロチン」

Cefalotin
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a682860
Pregnancy; category	AU: A; US: B (No risk in non-human studies); ;
Routes of; administration	Intravenous
ATC code	J01DB03 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only);
Pharmacokinetic data
Bioavailability	n/a
Protein binding	65 to 80%
Metabolism	Hepatic
Biological half-life	30 minutes to 1 hour
Excretion	Renal
Identifiers
	IUPAC name (6R,7R)-3-[(acetoxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
CAS Number	153-61-7 ;
PubChem CID	6024;
DrugBank	DB00456 ;
ChemSpider	5802 ;
UNII	R72LW146E6;
KEGG	D07635 ;
ChEBI	CHEBI:124991 ;
ChEMBL	CHEMBL617 ;
ECHA InfoCard	100.005.288
Chemical and physical data
Formula	C16H16N2O6S2
Molar mass	396.44 g/mol
3D model (Jmol)	Interactive image;
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)Cc3sccc3)COC(=O)C)C(=O)O ;
	InChI InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1 ; Key:XIURVHNZVLADCM-IUODEOHRSA-N ;
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