細胞性免疫
WordNet
- relating to cells; "cellular walls"; "cellular physiology"
- characterized by or divided into or containing cells or compartments (the smallest organizational or structural unit of an organism or organization); "the cellular construction of a beehive"; "any effective opposition to a totalitarian regime must be secretive and cellular"
- (medicine) the condition in which an organism can resist disease (同)resistance
- the quality of being unaffected by something; "immunity to criticism"
PrepTutorEJDIC
- 〈U〉(病気に対する)免疫《+『from』(『to, against』)+『名』》 / (義務・税などの)免除《+『from』(『to, against』)+『名』》
- 細胞の,細胞質の,細胞状の / 小室(小区画)のある / (生地など)目の透いている
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/12 14:11:41」(JST)
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Cell-mediated immunity is an immune response that does not involve antibodies, but rather involves the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen.
Historically, the immune system was separated into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells. CD4 cells or helper T cells provide protection against different pathogens. Cytotoxic T cells cause death by apoptosis without using cytokines, therefore in cell-mediated immunity cytokines are not always present.
The innate immune system and the adaptive immune system each comprise both humoral and cell-mediated components.
Cellular immunity protects the body by:
- T-cell mediated immunity or T-cell immunity : activating antigen-specific cytotoxic T cells that are able to induce apoptosis in body cells displaying epitopes of foreign antigen on their surface, such as virus-infected cells, cells with intracellular bacteria, and cancer cells displaying tumor antigens;
- activating macrophages and natural killer cells, enabling them to destroy pathogens; and
- stimulating cells[clarification needed] to secrete a variety[clarification needed] of cytokines that influence the function of other cells[clarification needed] involved in adaptive immune responses and innate immune responses.[citation needed]
Cell-mediated immunity is directed primarily at microbes that survive in phagocytes and microbes that infect non-phagocytic cells. It is most effective in removing virus-infected cells, but also participates in defending against fungi, protozoans, cancers, and intracellular bacteria. It also plays a major role in transplant rejection.
References
- Cell-mediated immunity (Encyclopædia Britannica)
- Chapter 8:T Cell-Mediated Immunity Immunobiology: The Immune System in Health and Disease. 5th edition.
Further reading
- Cell-Mediated Immunity. Murphy
- Cell-mediated immunity: How T cells recognize and respond to foreign antigens
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The main cell types in blood
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Cellular/
HSCs |
Myeloid/
CFU-GEMM |
| CFU-GM |
CFU-G:
Granulocytes |
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CFU-M:
Monocytes/
MPS |
| Macrophages |
- Histiocytes
- Kupffer cells
- Alveolar macrophage
- Microglia
- Osteoclasts
- Epithelioid cells
- giant cells
- Langhans giant cells, Foreign-body giant cell
- Touton giant cells
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| CFU-DL |
- Dendritic cells
- Langerhans cell
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| Common |
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| CFU-Baso |
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| CFU-Eos |
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| MEP |
| CFU-Meg |
- Megakaryoblast
- Promegakaryocyte
- Megakaryocyte
- Platelets
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| CFU-E |
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| CFU-Mast |
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| Noncellular |
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Immunology: lymphocytic adaptive immune system and complement
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| Lymphoid |
| Antigens |
- Antigen presentation/Professional APCs: Dendritic cell
- Macrophage
- B cell
- Immunogen
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| Antibodies |
- Antibody
- Monoclonal antibodies
- Polyclonal antibodies
- Autoantibody
- Microantibody
- Polyclonal B cell response
- Allotype
- Isotype
- Idiotype
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Immunity vs.
tolerance |
- action: Immunity
- Autoimmunity
- Alloimmunity
- Allergy
- Hypersensitivity
- Inflammation
- Cross-reactivity
- inaction: Tolerance
- Central
- Peripheral
- Clonal anergy
- Clonal deletion
- Tolerance in pregnancy
- Immunodeficiency
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| Immunogenetics |
- Affinity maturation (Somatic hypermutation
- Clonal selection)
- V(D)J recombination
- Junctional diversity
- Immunoglobulin class switching
- MHC/HLA
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| Lymphocytes |
- Cellular (T cell)
- Humoral (B cell)
- NK cell
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| Substances |
- Cytokines
- Opsonin
- Cytolysin
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Hypersensitivity and autoimmune diseases (279.5–6)
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Type I/allergy/atopy
(IgE) |
| Foreign |
- Atopic eczema
- Allergic urticaria
- Allergic rhinitis (Hay fever)
- Allergic asthma
- Anaphylaxis
- Food allergy
- common allergies include: Milk
- Egg
- Peanut
- Tree nut
- Seafood
- Soy
- Wheat
- Penicillin allergy
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| Autoimmune |
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Type II/ADCC
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| Foreign |
- Hemolytic disease of the newborn
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| Autoimmune |
| Cytotoxic |
- Autoimmune hemolytic anemia
- Immune thrombocytopenic purpura
- Bullous pemphigoid
- Pemphigus vulgaris
- Rheumatic fever
- Goodpasture's syndrome
- Guillain–Barré syndrome
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| "Type V"/receptor |
- Graves' disease
- Myasthenia gravis
- Pernicious anemia
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Type III
(Immune complex) |
| Foreign |
- Henoch–Schönlein purpura
- Hypersensitivity vasculitis
- Reactive arthritis
- Farmer's lung
- Post-streptococcal glomerulonephritis
- Serum sickness
- Arthus reaction
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| Autoimmune |
- Systemic lupus erythematosus
- Subacute bacterial endocarditis
- Rheumatoid arthritis
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Type IV/cell-mediated
(T cells) |
| Foreign |
- Allergic contact dermatitis
- Mantoux test
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| Autoimmune |
- Diabetes mellitus type 1
- Hashimoto's thyroiditis
- Multiple sclerosis
- Coeliac disease
- Giant-cell arteritis
- Postorgasmic illness syndrome
- Reactive arthritis
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| GVHD |
- Transfusion-associated graft versus host disease
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Unknown/
multiple |
| Foreign |
- Hypersensitivity pneumonitis
- Allergic bronchopulmonary aspergillosis
- Transplant rejection
- Latex allergy (I+IV)
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| Autoimmune |
- Sjögren's syndrome
- Autoimmune hepatitis
- Autoimmune polyendocrine syndrome
- Autoimmune adrenalitis
- Systemic autoimmune disease
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UpToDate Contents
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English Journal
- Development of the LYVE-1 gene with an acidic-amino-acid-rich (AAAR) domain in evolution is associated with acquisition of lymph nodes and efficient adaptive immunity.
- Huang SS1, Li YW2, Wu JL2, Johnson FE3, Huang JS4.
- Journal of cellular physiology.J Cell Physiol.2018 Apr;233(4):2681-2692. doi: 10.1002/jcp.26159. Epub 2017 Oct 4.
- PMID 28833090
- Shrimp humoral responses against pathogens: antimicrobial peptides and melanization.
- Tassanakajon A1, Rimphanitchayakit V2, Visetnan S2, Amparyup P3, Somboonwiwat K2, Charoensapsri W3, Tang S3.
- Developmental and comparative immunology.Dev Comp Immunol.2018 Mar;80:81-93. doi: 10.1016/j.dci.2017.05.009. Epub 2017 May 10.
- PMID 28501515
- Increased expression of PD-L1 and PD-L2 in dermal fibroblasts from alopecia areata mice.
- Li Y1, Kilani RT1, Pakyari M1, Leung G1, Nabai L1, Ghahary A1.
- Journal of cellular physiology.J Cell Physiol.2018 Mar;233(3):2590-2601. doi: 10.1002/jcp.26134. Epub 2017 Sep 4.
- PMID 28777458
Japanese Journal
- Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.
- Tumor growth suppression by the combination of nanobubbles and ultrasound
- Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells.
Related Links
- cell-·me·di·at·ed im·mu·ni·ty (CMI), , cellular immunity Immune responses mediated by activated, antigen-specific T lymphocytes. These T cells may function as effector cells or may orchestrate propagation of the inflammatory ...
- He said that a part of the problem was that antibodies are not designed to recognise cells and his company built a therapy around the second arm of the immune system, called cellular immunity, where T-cells seek out and destroy ...
Related Pictures
★リンクテーブル★
[★]
- 英
- cellular immunity
- 同
- 細胞媒介性免疫反応 細胞媒介免疫 cell-mediated immunity CMI、ツベルクリン型免疫、胸腺依存型免疫、細胞性過敏症
- 関
- 免疫
[★]
[★]
- 関
- cell-mediated immunity、cellular immunity
[★]
- 関
- cell、cell-mediated、cellularity、cyto