WordNet
- relating to cells; "cellular walls"; "cellular physiology"
- characterized by or divided into or containing cells or compartments (the smallest organizational or structural unit of an organism or organization); "the cellular construction of a beehive"; "any effective opposition to a totalitarian regime must be secretive and cellular"
- oxygen deficiency causing a very strong drive to correct the deficiency
PrepTutorEJDIC
- 細胞の,細胞質の,細胞状の / 小室(小区画)のある / (生地など)目の透いている
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- 1. 低酸素血症の酸素供給およびメカニズム oxygenation and mechanisms of hypoxemia
- 2. 高炭酸ガス血症患者における酸素の使用 use of oxygen in patients with hypercapnia
- 3. 血管新生阻害剤の概要 overview of angiogenesis inhibitors
- 4. 高山病：生理学、危険因子、および一般的な予防法 high altitude illness physiology risk factors and general prevention
- 5. コンタクトレンズの合併症 complications of contact lenses
English Journal
- Adrenomedullin is a therapeutic target in colorectal cancer.
- Wang L1, Gala M, Yamamoto M, Pino MS, Kikuchi H, Shue DS, Shirasawa S, Austin TR, Lynch MP, Rueda BR, Zukerberg LR, Chung DC.Author information 1Gastrointestinal Unit Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Gastroenterology Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.AbstractThe KRAS oncogene influences angiogenesis, metastasis and chemoresistance in colorectal cancers (CRCs), and these processes are all enhanced in hypoxic conditions. To define functional activities of mutant KRAS in a hypoxic microenvironment, we first performed cDNA microarray experiments in isogenic DKs5 and DKO3 colon cancer cell lines that differ only by their expression of mutant KRAS (K-ras(D13) ). Adrenomedullin (ADM) was identified as one of the most significantly upregulated genes in DKs5 cells that express the KRAS oncogene in hypoxia (3.2-fold, p = 1.47 × 10(-5) ). Ectopic expression of mutant KRAS (K-ras(V12) ) in Caco-2 cells (K-ras(WT) ) induced ADM, whereas selective knockdown of mutant KRAS alleles (K-ras(D13) or K-ras(V12) ) in HCT116, DLD1 and SW480 colon cancer cells suppressed the expression of ADM in hypoxia. Knockdown of ADM in colon tumor xenografts blocked angiogenesis and stimulated apoptosis, resulting in tumor suppression. Furthermore, ADM also regulated colon cancer cell invasion in vitro. Among 56 patients with CRC, significantly higher expression levels of ADM were observed in samples harboring a KRAS mutation. Collectively, ADM is a new target of oncogenic KRAS in the setting of hypoxia. This observation suggests that therapeutic targets may differ depending upon the specific tumor microenvironment.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 May 1;134(9):2041-50. doi: 10.1002/ijc.28542. Epub 2013 Nov 7.
- The KRAS oncogene influences angiogenesis, metastasis and chemoresistance in colorectal cancers (CRCs), and these processes are all enhanced in hypoxic conditions. To define functional activities of mutant KRAS in a hypoxic microenvironment, we first performed cDNA microarray experiments in isogenic
- PMID 24519534
- Overexpression of hypoxia-inducible factor 1 alpha impacts FoxP3 levels in mycosis fungoides-Cutaneous T-cell lymphoma: Clinical implications.
- Alcántara-Hernández M1, Torres-Zárate C, Pérez-Montesinos G, Jurado-Santacruz F, Domínguez-Gómez MA, Peniche-Castellanos A, Ferat-Osorio E, Neri N, Nambo MJ, Alvarado-Cabrero I, Moreno-Lafont M, Huerta-Yepez S, Bonifaz LC.Author information 1Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Instituto Mexicano del Seguro Social, México city, México; Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto, Politécnico Nacional, México city, México.AbstractMycosis fungoides (MF) is the most common variant of primary cutaneous T-cell lymphoma, and decreased forkhead box P3 (FoxP3) expression has been reported in MF late stages. Hypoxia-inducible factor 1 alpha (HIF-1α) may regulate FoxP3 expression; however, it is unknown whether HIF-1α is expressed in the CD4(+) T cells of MF patients and how it could affect the expression of FoxP3. Therefore, we evaluated the expression of HIF-1α and FoxP3 in CD4(+) T cells obtained from the skin lesions of MF patients. We found increased cell proliferation and an increase in CD4(+) T cells with an aberrant phenotype among early stage MF patients. HIF-1α was overexpressed in these CD4(+) T cells. In addition, we found a decrease in the percentage of FoxP3(+) cells both in the skin of MF patients, when compared with control skin samples, and with disease progression. In addition, a negative correlation was established between HIF-1α and FoxP3 expression. Skin HIF-1α expression in MF patients correlated with the extent of the affected area and increased with the disease progression. Finally, we showed that ex vivo inhibition of HIF-1α degradation increases the percentage of FoxP3(+) T cells in skin lesions. Our results suggest that overexpression of HIF-1α affects the levels of FoxP3 in MF patients, which could have relevant implications in terms of disease outcome.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 May 1;134(9):2136-45. doi: 10.1002/ijc.28546. Epub 2013 Nov 4.
- Mycosis fungoides (MF) is the most common variant of primary cutaneous T-cell lymphoma, and decreased forkhead box P3 (FoxP3) expression has been reported in MF late stages. Hypoxia-inducible factor 1 alpha (HIF-1α) may regulate FoxP3 expression; however, it is unknown whether HIF-1α is expressed
- PMID 24127318
- Hypoxia simultaneously alters satellite cell-mediated angiogenesis and hepatocyte growth factor expression.
- Flann KL1, Rathbone CR, Cole LC, Liu X, Allen RE, Rhoads RP.Author information 1Physiological Sciences Program, University of Arizona, Tucson, Arizona.AbstractSkeletal muscle regeneration is a multifaceted process requiring the spatial and temporal coordination of myogenesis as well as angiogenesis. Hepatocyte growth factor (HGF) plays a pivotal role in myogenesis by activating satellite cells (SC) in regenerating muscle and likely plays a role as a contributor to revascularization. Moreover, repair of a functional blood supply is critical to ameliorate tissue ischemia and restore skeletal muscle function, however effects of hypoxia on satellite cell-mediated angiogenesis remain unclear. The objective of this study was to examine the role of HGF and effect of hypoxia on the capacity of satellite cells to promote angiogenesis. To characterize the role of HGF, a microvascular fragment (MVF) culture model coupled with satellite cell conditioned media (CM) was employed. The activity of HGF was specifically blocked in SC CM reducing sprout length compared to control CM. In contrast, MVF sprout number did not differ between control or HGF-deficient SC CM media. Next, we cultured MVF in the presence of CM from satellite cells exposed to normoxic (20% O2 ) or hypoxic (1% O2 ) conditions. Hypoxic CM recapitulated a MVF angiogenic response identical to HGF deficient satellite cell CM. Hypoxic conditions increased satellite cell HIF-1α protein abundance and VEGF mRNA abundance but decreased HGF mRNA abundance compared to normoxic satellite cells. Consistent with reduced HGF gene expression, HGF promoter activity decreased during hypoxia. Taken together, this data indicates that hypoxic modulation of satellite cell-mediated angiogenesis involves a reduction in satellite cell HGF expression. J. Cell. Physiol. 229: 572-579, 2014. © 2013 Wiley Periodicals, Inc.
- Journal of cellular physiology.J Cell Physiol.2014 May;229(5):572-9. doi: 10.1002/jcp.24479.
- Skeletal muscle regeneration is a multifaceted process requiring the spatial and temporal coordination of myogenesis as well as angiogenesis. Hepatocyte growth factor (HGF) plays a pivotal role in myogenesis by activating satellite cells (SC) in regenerating muscle and likely plays a role as a contr
- PMID 24122166
Japanese Journal
- TRPA1 underlies a sensing mechanism for O(2).
- Takahashi Nobuaki,Kuwaki Tomoyuki,Kiyonaka Shigeki,Numata Tomohiro,Kozai Daisuke,Mizuno Yusuke,Yamamoto Shinichiro,Naito Shinji,Knevels Ellen,Carmeliet Peter,Oga Toru,Kaneko Shuji,Suga Seiji,Nokami Toshiki,Yoshida Jun-Ichi,Mori Yasuo
- Nature chemical biology, 2011-08-28
- … 2011-08-29.Oxygen (O(2)) is a prerequisite for cellular respiration in aerobic organisms but also elicits toxicity. … Unexpectedly, TRPA1 is activated through relief from the same PHD-mediated inhibition in hypoxia. … In mice, disruption of the Trpa1 gene abolishes hyperoxia- and hypoxia-induced cationic currents in vagal and sensory neurons and thereby impedes enhancement of in vivo vagal discharges induced by hyperoxia and hypoxia. …
- NAID 120003307930
- Chronic Pulmonary Thromboembolism Pathologically Showing Homogeneous Cellular Alveolitis
- Miwa Seiichi,Shirai Masahiro,Kobayashi Shigeru,Kaida Yusuke,Suda Takafumi,Hayakawa Hiroshi,Chida Kingo
- Internal Medicine 50(19), 2195-2200, 2011
- … Examination of arterial blood gases on room air revealed hypoxia. … Biopsies of the lung specimen showed focal infarct with surrounding mild mononuclear cell infiltrates (homogenous cellular alveolitis). … Thus, finally the patient was diagnosed with chronic pulmonary thromboembolism, pathologically showing homogenous cellular alveolitis. …
- NAID 130001087903
Related Links
- Anaerobic metabolism occurs when the oxygen supply is unable to deliver enough oxygen to maintain aerobic energy production. It is a supply versus demand ... Oxygen Delivery decreases as as your body stays in a prolonged ...
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★リンクテーブル★
| リンク元 | 「cell hypoxia」「細胞低酸素症」 |
| 関連記事 | 「cellular」「hypoxia」 |
「cell hypoxia」
「細胞低酸素症」
「cellular」
- adj.
- 細胞の、細胞性の
「hypoxia」
- n.