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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/29 22:39:42」(JST)

Cefmenoxime is a third-generation cephalosporin antibiotic.

Yokota N, Koguchi M, Suzuki Y, Fukayama S, Ishihara R, Deguchi K, Oda S, Tanaka S, Nakane Y, Fukumoto T (1995). "Antibacterial activities of cefmenoxime against recent fresh clinical isolates from patients in sinusitis". Jpn J Antibiot 48 (5): 602–9. PMID 7637194.
Paladino J, Fell R (1994). "Pharmacoeconomic analysis of cefmenoxime dual individualization in the treatment of nosocomial pneumonia.". Ann Pharmacother 28 (3): 384–9. doi:10.1177/106002809402800316. PMID 8193431.
Duncker G, Reich U, Krausse R (1994). "Cefmenoxime in corneal organ culture.". Ophthalmologica 208 (5): 262–6. doi:10.1159/000310505. PMID 7816419.

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Case of late-onset bleb associated endophthalmitis caused by Rothia mucilaginosa.

Oie S1, Mochizuki K1, Ishida K2, Nakayama A3, Ohkusu K4.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.J Infect Chemother.2016 Mar 18. pii: S1341-321X(16)00056-8. doi: 10.1016/j.jiac.2016.02.007. [Epub ahead of print]
Rothia mucilaginosa is a gram-positive coagulase-negative coccus of the family Micrococcaceae. Although R. mucilaginosa forms part of the oropharyngeal microflora, it has only recently been isolated in ocular infections. We report a case of a 41-year-old man who developed late-onset bleb-related en
PMID 27008920

Inoue H1, Suzuki T, Inoue T, Hattori T, Nejima R, Todokoro D, Hoshi S, Eguchi H, Miyamoto H, Ohashi Y.
Cornea.Cornea.2015 Sep;34(9):1105-9. doi: 10.1097/ICO.0000000000000470.
PURPOSE: Moraxella species are rare causative pathogens of severe sight-threatening keratitis. The aim of this study was to analyze the clinical presentation, predisposing risk factors, in vitro antimicrobial susceptibility, and treatment associated with Moraxella keratitis.METHODS: We retrospective
PMID 25970435

Conjunctivitis caused by Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility and multidrug resistance.

Suzuki T1, Kitagawa Y, Maruyama Y, Yamaguchi S, Sakane Y, Miyamoto H, Ohashi Y.
Journal of clinical microbiology.J Clin Microbiol.2013 Dec;51(12):4246-8. doi: 10.1128/JCM.01946-13. Epub 2013 Sep 11.
We report two cases of conjunctivitis caused by Neisseria gonorrhoeae with reduced cephalosporin susceptibility. Patients showed no response to cefmenoxime eye drops and intravenous ceftriaxone administration. The patients' condition improved after the addition of oral minocycline. The isolates cont
PMID 24025911

安村佐都紀
耳鼻咽喉科臨床. 補冊 = Practica otologica. Suppl. (134), 63-65, 2012-07-01
… We experienced a case of anaphylactic shock after nasal nebulizer contained cefmenoxime hydrochloride (CMX) and Rinderon. …
NAID 10030773908

鈴木健策
耳鼻咽喉科臨床 101(5), 355-360, 2008-05-01
… The study examined the efficacy of treatment by puncture and repetitive irrigation of the maxillary sinus using an indwelling tube.Subjects: The subjects consisted of 52 cases (sinuses) of maxillary sinusitis in 51 patients (10 to 80 years old, averaged 52.7 years old) that had not responded at all to pharmacotherapy (including clarithromycin) and nebulized aerosol therapy (cefmenoxime hydrochloride) for more than 1 month after the acute stage. …
NAID 10021294529

鳴戸理佐,藤澤利行,中島真幸,鈴木賢二
耳鼻咽喉科展望 51(Supplement), s11-s14, 2008
副鼻腔炎の治療方法の一つとしてエアロゾル吸入療法がある。使用される吸入器はジェット式加圧ネブライザーや超音波ネブライザーであるが, 今回我々は加圧ネブライザーに振動を付加したPARI社製ダブルコンプレッサー式ネブライザーの効果 (上顎洞内へのエアロゾルの移行) につき検討した。ヒト副鼻腔モデルを用いた基礎的研究と副鼻腔炎に対するCaldwell Luc手術時における臨床的研究とを行った。薬剤は塩酸 …
NAID 130004911615

リンク元	「セフメノキシム」
関連記事	「hydrochloride」

Cefmenoxime
Systematic (IUPAC) name
	(6R,7R)-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-; 2-methoxyimino-acetyl]amino}-3-[(1-methyltetrazol-; 5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]; oct-2-ene-2-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Intramuscular, intravenous
Pharmacokinetic data
Bioavailability	100% (given IM)
Protein binding	50% to 70%
Metabolism	Negligible
Biological half-life	1 hour
Excretion	Renal, unchanged
Identifiers
CAS Number	65085-01-0
ATC code	J01DD05 (WHO)
PubChem	CID 9570757
DrugBank	DB00267
ChemSpider	7845223
UNII	KBZ4844CXN
KEGG	D07641
ChEBI	CHEBI:55490
ChEMBL	CHEMBL1201224
Chemical data
Formula	C16H17N9O5S3
Molar mass	511.562 g/mol
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)CSc4nnnn4C)C(=O)O ;
	InChI InChI=1S/C16H17N9O5S3/c1-24-16(20-22-23-24)33-4-6-3-31-13-9(12(27)25(13)10(6)14(28)29)19-11(26)8(21-30-2)7-5-32-15(17)18-7/h5,9,13H,3-4H2,1-2H3,(H2,17,18)(H,19,26)(H,28,29)/b21-8-/t9-,13-/m1/s1 ; Key:HJJDBAOLQAWBMH-YCRCPZNHSA-N ;
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