WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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(2S,3R)-2-[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl-amino]-3-hydroxy-butyric acid monohydrate.

Ji CX, Cui YT, Yang DL, Guo C.AbstractIn the title compound, C(11)H(17)N(3)O(6)·H(2)O, an important building block of the medicine cefbuperazone sodium, the piperazine ring adopts a screw-boat conformation. Inter-molecular O-H⋯O and intra-molecular N-H⋯O hydrogen bonds are observed. The water mol-ecule participates as both donor and acceptor in this framework.
Acta crystallographica. Section E, Structure reports online.Acta Crystallogr Sect E Struct Rep Online.2008 Jun 19;64(Pt 7):o1292. doi: 10.1107/S1600536808017832.
In the title compound, C(11)H(17)N(3)O(6)·H(2)O, an important building block of the medicine cefbuperazone sodium, the piperazine ring adopts a screw-boat conformation. Inter-molecular O-H⋯O and intra-molecular N-H⋯O hydrogen bonds are observed. The water mol-ecule participates as both donor an
PMID 21202922

Host resistance to an intragastric infection with Listeria monocytogenes in mice depends on cellular immunity and intestinal bacterial flora.

Okamoto M, Nakane A, Minagawa T.SourceDepartment of Microbiology, Hokkaido University School of Medicine, Sapporo, Japan.
Infection and immunity.Infect Immun.1994 Aug;62(8):3080-5.
Suckling and adult mice were infected intragastrically with different doses of viable Listeria monocytogenes. The 50% lethal dose for the intragastric infection was 10(3.7) CFU for suckling mice, while adult mice were highly resistant and the 50% lethal dose was more than 10(9.3) CFU. When adult mic
PMID 8039875

Kumae T, Saburi Y, Nasu M, Misumi J, Kawata N.SourceDepartment of Hygiene, Hirosaki University School of Medicine, Japan.
Chemotherapy.Chemotherapy.1989;35(4):260-6.
To investigate the in vivo effect of antimicrobial agent on neutrophil chemiluminescence and serum opsonic activity, cefbuperazone sodium (CBPZ) was administered to healthy male volunteers via an intravenous drip. A peripheral blood sample (10 ml) was collected 7 times: prior to injection, then 1, 3
PMID 2766868

豊永義清 [他],黒須義家,甲田直也,井田博幸,望月弘,熊谷公明,赤塚順一,杉田守正,川村悟朗,岡部武,堀誠,高橋孝行
The Japanese Journal of Antibiotics 36(4), 739-770, 1983
… T-1982 (Cefbuperazone) は7α-Methoxycephem系抗生物質としては第5番目に本邦での検討を行つた薬剤であり, 富山化学工業 (株) 及び科研製薬 (株) で共同開発され, 化学名はSodium 7β-[(2R, 33)-2-(4-ethyl2, 3-dioxo-1-piperazinecarboxamido)-3-hydroxybutanamido]-7α-methoxy-3-[(1-methyl-1H-tetrazo1-5-yl)thiomethy1]-3-cephem-4-carboxylateで7β 位の側鎖のD-ThreonineにPiperacillin (PIPC), Cefbperazone (CPZ) に用いた4-Ethyl-2, 3-dioxopiperazineを置換した構造である …
NAID 130004393851

益子仁,目黒英典,大成滋,金保沫,中條真美子,田島剛,藤井良知
The Japanese Journal of Antibiotics 36(4), 728-735, 1983
… T-1982 (Cefbuperazone) は富山化学工業 (株) と科研製薬 (株) で共同開発された注射用新Cephamycin系抗生物質で, 化学名はSodium 7β-[(2R, 35)-2-(4-ethyl-2, 3-dioxo-1-piperazinecarboxamido)-3-hydroxybutanamido]-7α-methoxy-3-[(1-methyl-1H-tetrazol-5-yl) thiomethyl]-3-cephem-4-carboxylateである。 …
NAID 130004393849

福田宰 [他],田島朝信,徳永達也,三森寛幸,橋本晏理,前山昌男
The Japanese Journal of Antibiotics 36(5), 1097-1102, 1983
… T-1982 (Cefbuperazone) は富山化学 (株) 及び科研製薬 (株) で共同開発中の新しい注射用セファマイシン系抗生物質である。 … 化学名は, Sodium 7β-[(2R, 3S)-2-(4-ethyl-2, 3-dioxo-1-piperazinecarboxamido)-3-hydroxybutanamido]-7β-methoxy-3-[(1-methyl-1H-tetrazol-5-yl) thiomethyl]-3-cephem-4-carboxylateで,分子式はC22H28N9NaO9S2, 分子量は649.63である。 …
NAID 130004130431